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DaveManuel.com · Institutional Ownership · Who Owns It

AGIOS PHARMACEUTICALS INC (AGIO)

Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.

239
Reporting holders
$2.6B
Reported value
110.7%
Of shares outstanding
4.9%
Calls
0.8%
Puts
+3
Holder change

Institutions report 66,107,443 shares against 59,701,882 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.

Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.

Holders

Download these holders as CSV

FilerValueShares Their book Held Change
BlackRock, Inc.$239.6M6,455,9970.00%8q+12.2%+$26.0M
FARALLON CAPITAL MANAGEMENT, L.L.C.$219.6M5,917,4001.01%27q+4.1%+$8.7M
ARMISTICE CAPITAL, LLC$193.3M
incl. $104.3M options CALL
2,400,0002.37%16q-11.6%-$25.5M
STATE STREET CORP$131.1M3,533,6330.00%31q+5.0%+$6.3M
Lynx1 Capital Management LP$126.5M3,408,93714.62%3q+30.5%+$29.6M
D. E. Shaw & Co., Inc.$115.3M3,107,0050.05%31q+15.9%+$15.8M
VANGUARD PORTFOLIO MANAGEMENT LLC$107.6M2,898,1970.00%2q+11.0%+$10.7M
VANGUARD CAPITAL MANAGEMENT LLC$99.5M2,681,8450.00%2q+1.9%+$1.8M
Erste Asset Management GmbH$82.0M2,154,9000.64%31q-20.3%-$20.9M
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.$78.3M2,110,8090.12%3q+41.2%+$22.9M
SUSQUEHANNA INTERNATIONAL GROUP, LLP$62.5M
incl. $11.4M options CALL+PUT
1,375,5580.00%31q+2.3%+$1.4M
GEODE CAPITAL MANAGEMENT, LLC$58.4M1,574,2680.00%31q+7.2%+$3.9M
ADAR1 Capital Management, LLC$47.8M1,288,0532.19%6q+815.6%+$42.6M
BNP PARIBAS ASSET MANAGEMENT Holding S.A.$47.5M1,280,0440.05%31q-19.0%-$11.2M
DIMENSIONAL FUND ADVISORS LP$46.3M1,248,7380.01%31q+8.4%+$3.6M
GW&K Investment Management, LLC$44.8M1,206,6150.35%10q-0.7%-$307.5K
GOLDMAN SACHS GROUP INC$42.7M1,150,9320.00%31q+42.8%+$12.8M
UBS Group AG$36.6M985,8310.00%31q+643.8%+$31.7M
MORGAN STANLEY$35.7M963,2560.00%35qHELD
CITADEL ADVISORS LLC$33.9M
incl. $6.7M options CALL+PUT
732,6870.00%31q+18.2%+$5.2M
Nuveen, LLC$32.4M873,5600.01%6q+20.9%+$5.6M
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP$30.1M810,5300.01%2q+223.6%+$20.8M
Foresite Capital Management VI LLC$29.1M785,0004.53%3q+49.5%+$9.6M
JANE STREET GROUP, LLC$27.7M
incl. $9.4M options CALL+PUT
492,5980.00%15q-28.1%-$10.8M
AQR CAPITAL MANAGEMENT LLC$25.4M684,3400.01%10q+1779.5%+$24.0M
Parkman Healthcare Partners LLC$24.8M669,0462.54%4q+65.8%+$9.9M
SCS Capital Management LLC$22.7M612,8500.21%6qHELD
Qube Research & Technologies Ltd$22.2M597,6380.02%3q+218.5%+$15.2M
NORTHERN TRUST CORP$20.6M554,7090.00%31q+8.9%+$1.7M
Defilade Capital Management, L.P.$20.3M546,8482.72%newNEW
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$20.0M538,1280.00%31q+12.8%+$2.3M
TWO SIGMA INVESTMENTS, LP$19.9M536,3800.01%4q+113.2%+$10.6M
Rock Springs Capital Management LP$19.8M532,5630.96%30q-33.4%-$9.9M
Schonfeld Strategic Advisors LLC$19.3M520,0830.07%2q+160.0%+$11.9M
BANK OF AMERICA CORP /DE/$18.8M507,8690.00%31qHELD
Point72 Asset Management, L.P.$18.8M506,3440.02%4qHELD
Legal & General Group Plc$16.1M434,7190.00%31q+2.5%+$400.9K
VANGUARD FIDUCIARY TRUST CO$14.7M395,8680.00%2q+3.6%+$513.9K
PANAGORA ASSET MANAGEMENT INC$13.9M373,9310.04%3q+56.8%+$5.0M
KENNEDY CAPITAL MANAGEMENT LLC$13.9M373,2300.25%10q+35.5%+$3.6M
JPMORGAN CHASE & CO$13.8M
incl. $11.4K options PUT
359,7560.00%31q+137.4%+$8.0M
Connor, Clark & Lunn Investment Management Ltd.$13.3M359,5500.03%9q-20.1%-$3.4M
Squarepoint Ops LLC$11.9M321,1380.01%3q+53.7%+$4.2M
GROUP ONE TRADING LLC$11.5M
incl. $5.8M options CALL+PUT
151,9940.02%3q-12.3%-$1.6M
Ensign Peak Advisors, Inc$11.0M297,6300.02%19q+4430.1%+$10.8M
BNP PARIBAS FINANCIAL MARKETS$10.0M269,3830.00%31q-17.7%-$2.2M
Tetragon Partners GP Ltd$9.5M
incl. $1.9M options CALL
205,5791.49%3q+24.7%+$1.9M
ALGERT GLOBAL LLC$9.2M248,0070.11%10q-7.6%-$758.1K
PRICE T ROWE ASSOCIATES INC /MD/$8.1M218,9660.00%31q-26.7%-$3.0M
Palo Alto Investors LP$7.9M213,6011.10%6qHELD
Assenagon Asset Management S.A.$7.7M207,9100.00%4q+209.6%+$5.2M
Bank of New York Mellon Corp$7.4M198,6850.00%31q+6.4%+$441.4K
Jump Financial, LLC$6.8M182,7730.05%newNEW
BOOTHBAY FUND MANAGEMENT, LLC$6.5M
incl. $950.0K options CALL
149,8860.09%11qHELD
Invesco Ltd.$6.2M168,1530.00%31q+11.0%+$620.6K
FIRST TRUST ADVISORS LP$6.1M165,5870.00%newNEW
Ishara Investments LP$6.1M164,0004.47%newNEW
HRT FINANCIAL LP$6.0M160,7590.01%3q-17.7%-$1.3M
CITIGROUP INC$5.8M
incl. $2.4M options CALL+PUT
89,1670.00%31q+421.6%+$4.7M
MARSHALL WACE, LLP$5.2M138,8000.00%10q-69.0%-$11.5M
AMERICAN CENTURY COMPANIES INC$5.0M134,5120.00%16q+11.9%+$529.2K
Man Group plc$4.6M124,4660.01%2q-13.7%-$735.9K
ArrowMark Colorado Holdings LLC$4.4M117,7140.18%31q-70.8%-$10.6M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC$4.3M116,9090.00%31q+5.6%+$231.2K
Pictet Asset Management Holding SA$4.2M111,8610.00%12q-13.2%-$643.7K
Swiss National Bank$4.1M111,6600.00%31q+2.6%+$103.9K
CAPITAL FUND MANAGEMENT S.A.$3.9M104,0800.02%3q-19.6%-$944.5K
Universal- Beteiligungs- und Servicegesellschaft mbH$3.7M99,7260.01%6q+64.4%+$1.4M
Knott David M Jr$3.5M95,0581.86%3q+2.1%+$74.2K
Trexquant Investment LP$3.5M93,5390.02%3q+24.2%+$676.9K
Jain Global LLC$3.4M91,6470.01%newNEW
Caligan Partners LP$3.3M CALLoptions only0.16%15qOPTIONS
Caption Management, LLC$3.3M
incl. $1.9M options CALL
39,2490.02%10q+217.8%+$2.3M
RHUMBLINE ADVISERS$2.9M79,4410.00%31q+8.3%+$225.3K
Campbell & CO Investment Adviser LLC$2.7M73,0950.14%newNEW
Exome Asset Management LLC$2.6M70,5001.61%3q-43.6%-$2.0M
Edgestream Partners, L.P.$2.6M70,1950.08%3q-51.2%-$2.7M
Russell Investments Group, Ltd.$2.5M66,8560.00%26q+68.4%+$1.0M
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM$2.5M66,7960.00%31q-2.6%-$65.6K
TUDOR INVESTMENT CORP ET AL$2.4M65,7790.00%3q+13.1%+$283.1K
DEUTSCHE BANK AG\$2.3M62,2280.00%34q+23.5%+$439.5K
ALPS ADVISORS INC$2.2M60,0590.01%23q+25.9%+$458.6K
Seven Fleet Capital Management LP$2.1M56,9000.35%3q-72.8%-$5.7M
ALLIANCEBERNSTEIN L.P.$2.1M61,8640.00%31q+0.6%+$12.5K
Rafferty Asset Management, LLC$2.1M55,5800.00%30q-45.9%-$1.8M
Engineers Gate Manager LP$2.0M53,9120.03%3q+86.4%+$927.5K
WELLS FARGO & COMPANY/MN$2.0M53,2400.00%31q+133.9%+$1.1M
VANGUARD ASSET MANAGEMENT, Ltd$1.9M52,0500.00%2q-11.3%-$244.9K
XTX Topco Ltd$1.9M50,3660.02%3q-68.7%-$4.1M
SIMPLEX TRADING, LLC$1.9M CALL+PUToptions only0.00%31qOPTIONS
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main$1.8M49,7640.00%newNEW
BARCLAYS PLC$1.8M48,3000.00%31q-7.9%-$153.6K
HARBOR CAPITAL ADVISORS, INC.$1.7M46,5500.12%10q+8.2%+$131.5K
Quantinno Capital Management LP$1.6M43,5140.00%3q+57.7%+$590.9K
MARTINGALE ASSET MANAGEMENT L P$1.6M43,0090.04%2q+20.1%+$267.0K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.$1.5M41,4550.00%9q-1.5%-$22.9K
IEQ CAPITAL, LLC$1.5M40,4040.01%newNEW
Virtus Investment Advisers, LLC$1.5M39,4730.34%6q+27.5%+$316.0K
FMR LLC$1.4M39,0720.00%31q+328.4%+$1.1M
Aquatic Capital Management LLC$1.4M38,6270.05%3q+241.2%+$1.0M

Showing the largest 100 of 240 reported holders. The count of 239 above leaves out 1 position whose reported value failed our price check; it is listed here as filed.

What the insiders did

Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.

Officers and directors

DateInsiderRoleSideSharesValue
2026-08-04Gheuens SarahChief Medical OfficerSold30,000$914.4K
2026-10-26Gheuens SarahChief Medical OfficerSold7,866$296.5K
2026-07-01Gheuens SarahChief Medical OfficerSold4,007$150.5K

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q3 202643$73.4M2,209,18581840.0%
Q2 2026239$2.6B66,107,4433393635.8%
Q1 2026236$2.3B63,077,3033080826.4%
Q4 2025240$1.8B61,259,5585776689.7%
Q3 2025229$2.7B63,686,4144363706.1%
Q2 2025219$2.1B61,714,2812483731.0%
Q1 2025222$1.8B60,116,0053571731.2%
Q4 2024227$2.0B59,846,5093180691.0%
Q3 2024211$2.7B59,889,8342672681.4%
Q2 2024209$2.6B60,161,8784847810.9%
Q1 2024191$2.0B67,131,5414459541.4%
Q4 2023171$1.4B63,199,9682561390.8%
Q3 2023148$1.5B59,393,9911150471.2%
Q2 2023153$1.7B59,366,3011262491.0%
Q1 2023163$1.4B59,234,0491657561.0%
Q4 2022161$1.7B59,454,0652162491.6%
Q3 2022154$49.6B1,753,122,4652850460.1%
Q2 2022146$39.7B1,789,099,7992155430.0%
Q1 2022147$49.2B1,690,547,6171837540.0%
Q4 2021154$55.4B1,651,599,9392544560.0%
Q3 2021162$56.3B1,218,449,0121641640.1%
Q2 2021185$64.2B1,165,632,8263649610.1%
Q1 2021178$57.7B1,119,625,2581557650.1%
Q4 2020200$3.0B67,983,0633160702.4%
Q3 2020206$36.8B1,053,797,7713276530.0%
Q2 2020213$52.6B984,066,6804664560.1%
Q1 2020193$2.6B70,851,9833055652.1%
Q4 2019201$55.3B1,150,414,2693986470.1%
Q3 2019182$58.7B1,807,323,1932966520.1%
Q2 2019186$62.6B1,252,866,4372765580.1%
Q1 2019201$43.0B637,829,1784173470.2%
Q4 2018191$28.5B626,848,0632520.2%