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DaveManuel.com · Institutional Ownership · Who Owns It

AMYLYX PHARMACEUTICALS INC (AMLX)

Institutional ownership reported to the SEC as of Q2 2026, across 19 quarters.

208
Reporting holders
$2.1B
Reported value
103.6%
Of shares outstanding
0.6%
Calls
0.1%
Puts
+34
Holder change

Institutions report 115,464,889 shares against 111,423,048 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.

Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.

Holders

Download these holders as CSV

FilerValueShares Their book Held Change
FMR LLC$300.4M16,727,9090.01%18q+0.6%+$1.7M
BlackRock, Inc.$158.5M8,827,0850.00%8qHELD
PERCEPTIVE ADVISORS LLC$149.7M8,334,8822.25%8q+0.6%+$898.0K
TCG Crossover Management, LLC$112.1M6,243,8122.70%8qHELD
Commodore Capital LP$101.5M5,650,0006.04%4qHELD
Jupiter Topco LLC$94.0M5,236,1020.04%newFIRST
Saturn V Capital Management LP$83.0M4,624,10111.91%7q+6.3%+$4.9M
VANGUARD CAPITAL MANAGEMENT LLC$75.9M4,224,2240.00%2q+2.0%+$1.5M
MORGAN STANLEY$56.2M3,130,8080.00%18q+43.9%+$17.2M
Driehaus Capital Management LLC$54.5M3,036,9700.32%5q+1.7%+$894.8K
First Light Asset Management, LLC$54.3M3,023,2563.30%4q-5.2%-$3.0M
FRANKLIN RESOURCES INC$53.0M2,950,2250.01%3q+30.5%+$12.4M
GOLDMAN SACHS GROUP INC$51.3M2,858,2390.00%16q+8.8%+$4.2M
STATE STREET CORP$46.8M2,603,3370.00%18q+10.2%+$4.3M
GEODE CAPITAL MANAGEMENT, LLC$41.9M2,335,3150.00%18q+5.6%+$2.2M
JPMORGAN CHASE & CO$34.9M1,863,6500.00%18q+1067.2%+$31.9M
ADAGE CAPITAL PARTNERS GP, L.L.C.$34.1M1,900,0000.05%6q-46.6%-$29.8M
Siren, L.L.C.$26.6M1,480,5860.54%2q+20.4%+$4.5M
683 Capital Management, LLC$24.7M
incl. $1.7M options CALL
1,279,5121.21%9q-16.4%-$4.8M
EVENTIDE ASSET MANAGEMENT, LLC$23.8M1,327,5360.32%4q-12.3%-$3.3M
VANGUARD PORTFOLIO MANAGEMENT LLC$19.1M1,061,5340.00%2q+12.4%+$2.1M
Alyeska Investment Group, L.P.$18.9M1,053,0150.05%newNEW
Almitas Capital LLC$17.5M974,8814.20%9q-54.1%-$20.6M
Nantahala Capital Management, LLC$17.5M973,3680.29%8q+81.7%+$7.9M
DIMENSIONAL FUND ADVISORS LP$16.2M902,4630.00%7qHELD
Jones Hill Capital LP$16.1M894,0583.41%2q-44.1%-$12.7M
Woodline Partners LP$15.2M846,3870.05%6qHELD
NORTHERN TRUST CORP$14.9M831,7400.00%18q+6.6%+$930.9K
BANK OF AMERICA CORP /DE/$14.8M821,8410.00%18q-38.2%-$9.1M
Boxer Capital Management, LLC$14.4M800,0001.08%7qHELD
Aberdeen Group plc$13.2M737,6700.02%newNEW
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$13.0M725,0300.00%18q+1.2%+$158.1K
Connor, Clark & Lunn Investment Management Ltd.$12.9M721,0020.02%12q-17.0%-$2.6M
GREAT POINT PARTNERS LLC$12.6M700,0002.38%6q-60.0%-$18.9M
Balyasny Asset Management L.P.$12.3M684,9740.02%4q-38.1%-$7.6M
Qube Research & Technologies Ltd$12.2M681,3890.01%14q-3.0%-$374.4K
VANGUARD FIDUCIARY TRUST CO$11.2M623,0780.00%2q+6.3%+$663.2K
TWO SIGMA INVESTMENTS, LP$10.7M593,4350.01%11q+266.4%+$7.7M
DEUTSCHE BANK AG\$10.0M557,9370.00%18q-56.0%-$12.7M
ADAR1 Capital Management, LLC$9.6M
incl. $720.2K options PUT
494,3780.44%11q-50.6%-$9.8M
Rock Springs Capital Management LP$9.0M499,7640.44%6qHELD
FEDERATED HERMES, INC.$8.3M462,2050.01%16q+27.1%+$1.8M
SUSQUEHANNA INTERNATIONAL GROUP, LLP$8.0M
incl. $7.9M options CALL+PUT
10,3390.00%18q-74.0%-$22.9M
Nearwater Capital Markets, Ltd$7.6M425,0000.13%newNEW
Parkman Healthcare Partners LLC$7.2M398,7820.73%5q-35.8%-$4.0M
HighVista Strategies LLC$6.9M386,0801.58%3q+9.7%+$610.6K
STEMPOINT CAPITAL LP$6.9M384,3041.19%4q-71.3%-$17.2M
JANE STREET GROUP, LLC$6.8M
incl. $1.4M options CALL+PUT
299,5650.00%15qHELD
Logos Global Management LP$6.3M350,0000.27%4q-50.0%-$6.3M
Trexquant Investment LP$6.3M349,4390.04%newNEW
Nuveen, LLC$5.9M330,5210.00%5q+24.8%+$1.2M
Tetragon Partners GP Ltd$5.5M
incl. $152.7K options CALL
297,9260.87%5q-6.3%-$368.5K
Ensign Peak Advisors, Inc$5.5M305,4410.01%newNEW
iA Global Asset Management Inc.$5.5M303,7860.06%2qHELD
JUPITER ASSET MANAGEMENT LTD$4.9M274,9440.02%3q-53.6%-$5.7M
Bank of New York Mellon Corp$4.9M274,4350.00%5q+9.3%+$419.0K
UBS Group AG$4.9M271,8810.00%18q-16.2%-$941.8K
FIRST TRUST ADVISORS LP$4.6M254,5870.00%newNEW
SummitTX Capital, L.P.$4.1M227,6900.11%4qHELD
WELLINGTON MANAGEMENT GROUP LLP$3.8M212,8420.00%7q-11.9%-$515.6K
Cormorant Asset Management, LP$3.6M200,0000.18%4q-42.9%-$2.7M
Aldebaran Capital, LLC$3.5M195,8922.64%9q-1.0%-$35.9K
Walleye Capital LLC$3.5M
incl. $134.7K options CALL+PUT
186,5880.01%4q+202.4%+$2.3M
CITADEL ADVISORS LLC$3.4M
incl. $192.2K options PUT
178,6860.00%18q-56.6%-$4.4M
ORBIMED ADVISORS LLC$3.3M183,4000.06%newNEW
D. E. Shaw & Co., Inc.$3.1M174,2850.00%16q+134.8%+$1.8M
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC$3.1M173,4070.00%3q+10.4%+$293.1K
ACUTA CAPITAL PARTNERS, LLC$3.0M168,1152.10%4q+11.3%+$306.2K
NORGES BANK$2.9M159,9000.00%newNEW
Alpha Wave Global, LP$2.8M155,4220.04%8q+9.2%+$235.0K
PRICE T ROWE ASSOCIATES INC /MD/$2.6M145,1330.00%15q+19.5%+$425.6K
Swiss National Bank$2.6M144,2000.00%3q+10.7%+$249.6K
PFM Health Sciences, LP$2.6M143,7000.22%6q-1.1%-$28.3K
Invesco Ltd.$2.5M139,9420.00%6q-18.5%-$568.9K
WELLS FARGO & COMPANY/MN$2.3M128,1640.00%18q+70.7%+$953.3K
AMERIPRISE FINANCIAL INC$2.3M125,4840.00%newNEW
Lighthouse Investment Partners, LLC$2.2M122,9090.06%newNEW
Ikarian Capital, LLC$2.1M117,5000.23%newNEW
RHUMBLINE ADVISERS$2.0M112,9200.00%5q+4.1%+$80.0K
ALPS ADVISORS INC$2.0M112,4470.01%3q+25.0%+$403.5K
Elmind Capital, LP$2.0M112,0000.51%3qHELD
Campbell & CO Investment Adviser LLC$1.8M100,9630.10%4q+85.5%+$835.9K
Affinity Asset Advisors, LLC$1.8M98,9990.08%newNEW
SIMPLEX TRADING, LLC$1.7M CALL+PUToptions only0.00%18qOPTIONS
Russell Investments Group, Ltd.$1.6M87,5740.00%14q+47.6%+$507.0K
Quantinno Capital Management LP$1.5M80,8500.00%newNEW
ALLIANCEBERNSTEIN L.P.$1.5M104,4000.00%5q+29.2%+$328.0K
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM$1.4M79,8720.00%5q+22.9%+$267.1K
1492 Capital Management LLC$1.4M79,7510.42%newNEW
CITIGROUP INC$1.2M68,6840.00%18q+116.1%+$662.8K
Schonfeld Strategic Advisors LLC$1.2M66,8040.00%9q-14.1%-$197.4K
STATE OF WISCONSIN INVESTMENT BOARD$1.1M61,2780.00%4q-15.0%-$193.7K
Corient Private Wealth LP$1.1M59,3220.00%newNEW
Moody Aldrich Partners LLC$1.0M57,8020.19%newNEW
VANGUARD ASSET MANAGEMENT, Ltd$1.0M56,9480.00%2q+31.6%+$245.4K
Legal & General Group Plc$1.0M56,4770.00%5q+1.3%+$12.6K
BARCLAYS PLC$1.0M56,2580.00%18q-94.2%-$16.4M
MetLife Investment Management, LLC$1.0M55,7000.00%5q+8.0%+$73.9K
SG Americas Securities, LLC$994.0K55,3210.00%newNEW
Hudson Bay Capital Management LP$898.0K50,0000.00%newNEW

Showing the largest 100 of 208 reported holders.

What the company announced

Form 8-K filings from the last 120 days, showing only the items worth a reader's attention. Earnings releases, exhibit attachments and general disclosures are filed constantly and are left out. Filed is when the SEC received it; event is the date the company says the thing happened.

FiledEvent dateWhatSource
2026-09-082026-09-01Material agreement enteredfiling
2026-08-202026-08-19Material agreement enteredfiling

What the insiders did

Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.

Officers and directors

DateInsiderRoleSideSharesValue
2026-09-10Cohen Joshua BCo-Chief Executive OfficerSold30,464$980.5K ×2
2026-09-10Klee Justin B.Co-Chief Executive OfficerSold30,464$980.3K ×2
2026-10-05MILNE GEORGE M JRDirectorSold30,000$830.9K
2026-09-10FRATES JAMES MChief Financial OfficerSold10,810$349.8K ×2
2026-09-10Bedrosian Camille LChief Medical OfficerSold10,028$324.9K ×2
2026-09-10Mazzariello GinaChief Legal OfficerSold9,536$309.5K ×2
2026-07-09Mazzariello GinaChief Legal OfficerSold15,000$274.7K
2026-07-10Mazzariello GinaChief Legal OfficerSold15,000$264.1K

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q3 202634$16.1M553,433101440.0%
Q2 2026208$2.1B115,464,8894867540.7%
Q1 2026174$1.6B114,819,5542059500.7%
Q4 2025182$1.4B112,319,3093569440.5%
Q3 2025175$1.5B111,879,1515940490.6%
Q2 2025132$525.3M81,702,1353037370.3%
Q1 2025136$262.7M73,897,7373049300.4%
Q4 2024124$192.4M50,038,8852735401.7%
Q3 2024112$145.0M43,590,7232232332.6%
Q2 2024121$87.6M43,692,3132929435.2%
Q1 2024150$185.2M54,061,55827564716.8%
Q4 2023185$1.0B63,821,3693574439.8%
Q3 2023175$1.2B59,609,9473964446.0%
Q2 2023156$1.3B54,789,5682863406.6%
Q1 2023153$1.6B51,654,8154160355.5%
Q4 2022132$1.9B48,530,3844246353.3%
Q3 202299$1.3B39,936,88932362412.2%
Q2 202278$565.0M27,409,3832434136.5%
Q1 202271$316.3M24,208,47173002.0%