DaveManuel.com · Institutional Ownership · Who Owns It
DENALI THERAPEUTICS INC (DNLI)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
299
Reporting holders
$4.0B
Reported value
97.7%
Of shares outstanding
0.4%
Calls
0.4%
Puts
+25
Holder change
Institutions report 156,230,274 shares against 159,847,403 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | $416.1M | 16,178,963 | 0.27% | 5q | +89.9%+$197.0M |
| BlackRock, Inc. | $360.8M | 14,026,413 | 0.01% | 8q | +7.6%+$25.5M |
| BAILLIE GIFFORD & CO | $307.6M | 11,960,230 | 0.28% | 31q | -0.9%-$2.7M |
| STATE STREET CORP | $181.3M | 7,049,304 | 0.01% | 31q | +12.4%+$20.0M |
| Temasek Holdings (Private) Ltd | $180.4M | 7,012,974 | 0.48% | 31q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $166.6M | 6,477,057 | 0.01% | 2q | +5.8%+$9.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | $161.4M | 6,275,729 | 0.00% | 2q | +2.1%+$3.3M |
| FMR LLC | $116.7M | 4,535,836 | 0.01% | 31q | -0.9%-$1.0M |
| GOLDMAN SACHS GROUP INC | $106.9M | 4,155,895 | 0.01% | 31q | -5.7%-$6.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $102.2M | 3,973,342 | 0.01% | 31q | +6.6%+$6.3M |
| Holocene Advisors, LP | $100.4M | 3,905,225 | 0.23% | 5q | +22.2%+$18.3M |
| BAKER BROS. ADVISORS LP | $96.0M | 3,734,336 | 0.48% | 26q | HELD |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $81.3M | 3,161,972 | 0.01% | 31q | -28.7%-$32.7M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $80.7M | 3,136,149 | 0.01% | 31q | +27.3%+$17.3M |
| UBS Group AG | $80.3M | 3,120,592 | 0.01% | 31q | +21.4%+$14.1M |
| DIMENSIONAL FUND ADVISORS LP | $73.6M | 2,860,604 | 0.01% | 29q | +6.3%+$4.3M |
| NORGES BANK | $72.7M | 2,824,746 | 0.01% | 28q | -44.8%-$59.0M |
| Pictet Asset Management Holding SA | $71.9M | 2,791,206 | 0.07% | 12q | +9.1%+$6.0M |
| Capital Research Global Investors | $66.0M | 2,565,817 | 0.01% | 16q | +2.0%+$1.3M |
| Fisher Asset Management, LLC | $62.1M | 2,414,162 | 0.02% | 10q | -0.9%-$584.7K |
| ALLIANCEBERNSTEIN L.P. | $57.3M | 2,984,807 | 0.02% | 31q | +3.2%+$1.8M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $56.8M | 2,208,263 | 0.09% | 3q | +1828.2%+$53.9M |
| Casdin Capital, LLC | $52.6M | 2,045,000 | 2.63% | 31q | +11.1%+$5.3M |
| Crestline Management, L.P. | $49.1M | 1,910,732 | 91.90% | 31q | -13.6%-$7.7M |
| PRINCIPAL FINANCIAL GROUP INC | $36.5M | 1,420,083 | 0.02% | 31q | -4.0%-$1.5M |
| Foresite Capital Management VI LLC | $35.9M | 1,396,771 | 5.59% | 4q | +15.4%+$4.8M |
| Siren, L.L.C. | $35.9M | 1,396,513 | 0.73% | 8q | HELD |
| NORTHERN TRUST CORP | $35.7M | 1,389,765 | 0.00% | 31q | +6.0%+$2.0M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $34.9M | 1,355,514 | 0.03% | 5q | +357.2%+$27.2M |
| Aberdeen Group plc | $34.6M | 1,345,481 | 0.05% | 11q | -27.4%-$13.1M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $32.0M | 1,244,955 | 0.00% | 31q | +3.1%+$965.9K |
| BANK OF AMERICA CORP /DE/ | $31.7M | 1,230,957 | 0.00% | 31q | +8.5%+$2.5M |
| Artisan Partners Limited Partnership | $31.5M | 1,224,497 | 0.05% | 2q | +11.3%+$3.2M |
| Candriam S.C.A. | $30.6M | 1,189,886 | 0.14% | 21q | +8.2%+$2.3M |
| MILLENNIUM MANAGEMENT LLC | $29.0M | 1,125,748 | 0.01% | 10q | -10.5%-$3.4M |
| ADAR1 Capital Management, LLC | $26.5M | 1,029,080 | 1.21% | 10q | -45.0%-$21.7M |
| VANGUARD FIDUCIARY TRUST CO | $25.5M | 991,904 | 0.01% | 2q | +4.4%+$1.1M |
| MORGAN STANLEY | $24.7M | 961,050 | 0.00% | 35q | -13.0%-$3.7M |
| Bank of New York Mellon Corp | $20.6M | 800,283 | 0.00% | 31q | +4.2%+$829.3K |
| DAFNA Capital Management LLC | $19.0M | 739,014 | 3.62% | 6q | +132.0%+$10.8M |
| AMERICAN CENTURY COMPANIES INC | $18.3M | 712,526 | 0.01% | 30q | -23.9%-$5.7M |
| Cercano Management LLC | $16.1M | 625,000 | 2.14% | 15q | HELD |
| Nuveen, LLC | $15.7M | 608,967 | 0.00% | 6q | +106.0%+$8.1M |
| CITADEL ADVISORS LLC | $15.4M incl. $13.7M options CALL+PUT | 66,971 | 0.00% | 30q | -63.1%-$26.4M |
| Ensign Peak Advisors, Inc | $15.0M | 582,669 | 0.02% | 27q | +13.0%+$1.7M |
| MARSHALL WACE, LLP | $14.1M | 549,830 | 0.01% | 11q | -44.5%-$11.4M |
| SEGALL BRYANT & HAMILL, LLC | $13.4M | 519,483 | 0.16% | 7q | +1.8%+$229.9K |
| CITIGROUP INC | $12.5M | 487,278 | 0.00% | 31q | +1140.6%+$11.5M |
| Balyasny Asset Management L.P. | $11.1M CALL | options only | 0.01% | 2q | OPTIONS |
| Defilade Capital Management, L.P. | $10.1M | 391,866 | 1.35% | 3q | -71.2%-$24.9M |
| AQR CAPITAL MANAGEMENT LLC | $10.0M | 388,469 | 0.00% | 5q | +278.7%+$7.4M |
| Woodline Partners LP | $9.4M | 364,082 | 0.03% | 7q | HELD |
| Invesco Ltd. | $8.8M | 343,898 | 0.00% | 31q | +10.9%+$866.8K |
| ExodusPoint Capital Management, LP | $8.7M | 336,567 | 0.06% | new | NEW |
| Marex Group Ltd | $7.6M | 295,631 | 0.03% | 5q | +3.0%+$222.0K |
| JPMORGAN CHASE & CO | $7.6M | 287,019 | 0.00% | 31q | -11.4%-$978.0K |
| Swiss National Bank | $7.0M | 270,500 | 0.00% | 31q | -1.2%-$84.9K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6.5M incl. $3.4M options CALL+PUT | 123,258 | 0.00% | 29q | +144.2%+$3.9M |
| TD Asset Management Inc | $6.0M | 231,644 | 0.01% | 31q | -9.4%-$620.4K |
| GROUPAMA ASSET MANAGMENT | $5.9M | 229,939 | 0.07% | 11q | +11.0%+$586.6K |
| Privium Fund Management B.V. | $5.9M | 229,857 | 1.09% | 2q | -9.8%-$643.0K |
| XTX Topco Ltd | $5.8M | 226,953 | 0.08% | 2q | +188.9%+$3.8M |
| Alyeska Investment Group, L.P. | $5.6M | 219,334 | 0.01% | 3q | -88.7%-$44.3M |
| Susquehanna Portfolio Strategies, LLC | $5.4M | 211,474 | 0.09% | 3q | +33.9%+$1.4M |
| MASTERS CAPITAL MANAGEMENT LLC | $5.1M | 200,000 | 0.13% | 5q | -66.7%-$10.3M |
| Burkehill Global Management, LP | $5.1M | 200,000 | 0.19% | 3q | HELD |
| SCS Capital Management LLC | $5.1M | 197,998 | 0.05% | 6q | HELD |
| RHUMBLINE ADVISERS | $5.0M | 194,787 | 0.00% | 31q | +5.7%+$271.1K |
| WELLS FARGO & COMPANY/MN | $4.9M | 189,865 | 0.00% | 31q | +76.4%+$2.1M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $4.6M | 179,195 | 0.01% | 6q | +80.1%+$2.0M |
| Rhenman & Partners Asset Management AB | $4.6M | 179,000 | 0.43% | 6q | -10.1%-$514.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | $4.4M | 171,712 | 0.01% | 31q | +34.0%+$1.1M |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $4.3M | 166,181 | 0.03% | 25q | HELD |
| EDMOND DE ROTHSCHILD HOLDING S.A. | $4.2M | 165,080 | 0.06% | 23q | -26.9%-$1.6M |
| ALPS ADVISORS INC | $4.1M | 160,378 | 0.02% | 17q | +24.2%+$804.3K |
| E. Ohman J:or Asset Management AB | $4.1M | 160,000 | 0.10% | new | NEW |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.9M | 152,086 | 0.00% | 31q | -6.5%-$269.8K |
| DEUTSCHE BANK AG\ | $3.9M | 149,804 | 0.00% | 34q | +24.5%+$757.1K |
| GREAT LAKES ADVISORS, LLC | $3.7M | 145,045 | 0.03% | 2q | -36.1%-$2.1M |
| VANGUARD ASSET MANAGEMENT, Ltd | $3.6M | 141,153 | 0.00% | 2q | +12.7%+$409.2K |
| Man Group plc | $3.6M | 139,065 | 0.01% | 3q | HELD |
| Hudson Bay Capital Management LP | $3.3M | 130,000 | 0.01% | 11q | -62.5%-$5.6M |
| Odyssean, LLC | $3.2M | 125,062 | 0.52% | new | NEW |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3.0M | 117,348 | 0.00% | 31q | -6.5%-$208.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $3.0M | 115,775 | 0.01% | 31q | +3.7%+$105.0K |
| B. Metzler seel. Sohn & Co. AG | $2.9M | 112,300 | 0.02% | 3q | HELD |
| Legal & General Group Plc | $2.9M | 111,953 | 0.00% | 31q | +1.5%+$43.8K |
| Integrated Wealth Concepts LLC | $2.6M | 102,241 | 0.02% | 5q | +2.7%+$69.1K |
| PFM Health Sciences, LP | $2.6M | 100,966 | 0.22% | new | NEW |
| Integral Health Asset Management, LLC | $2.6M | 100,000 | 0.10% | new | NEW |
| Ghisallo Capital Management LLC | $2.6M | 100,000 | 0.05% | 3q | HELD |
| Lumbard & Kellner, LLC | $2.5M | 98,282 | 0.77% | 2q | +3.7%+$90.0K |
| Rafferty Asset Management, LLC | $2.5M | 96,342 | 0.01% | 25q | -36.1%-$1.4M |
| D.A. DAVIDSON & CO. | $2.3M | 87,741 | 0.01% | 3q | -20.4%-$578.5K |
| Russell Investments Group, Ltd. | $2.2M | 86,032 | 0.00% | 31q | +512.0%+$1.9M |
| MetLife Investment Management, LLC | $2.2M | 85,621 | 0.01% | 32q | +10.4%+$207.4K |
| BARCLAYS PLC | $2.2M | 84,892 | 0.00% | 30q | +63.0%+$843.8K |
| STATE OF WISCONSIN INVESTMENT BOARD | $2.2M | 84,652 | 0.00% | 31q | +2.8%+$59.0K |
| Creative Planning | $2.2M | 84,644 | 0.00% | 20q | +14.3%+$272.0K |
| AMERIPRISE FINANCIAL INC | $2.1M | 82,650 | 0.00% | 5q | -7.7%-$177.1K |
Showing the largest 100 of 299 reported holders.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-09-02 | Thornberry Nancy | Director | Sold | 11,439 | $261.9K ×2 |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 59 | $160.0M | 7,742,500 | 7 | 21 | 15 | 0.0% |
| Q2 2026 | 299 | $4.0B | 156,230,274 | 55 | 115 | 70 | 0.8% |
| Q1 2026 | 274 | $2.8B | 147,837,100 | 50 | 100 | 57 | 0.6% |
| Q4 2025 | 252 | $2.5B | 152,389,758 | 41 | 86 | 67 | 0.1% |
| Q3 2025 | 239 | $2.0B | 135,671,726 | 33 | 86 | 64 | 0.2% |
| Q2 2025 | 231 | $1.9B | 137,984,361 | 46 | 79 | 62 | 0.1% |
| Q1 2025 | 223 | $1.9B | 135,973,311 | 35 | 73 | 77 | 0.1% |
| Q4 2024 | 226 | $2.6B | 127,929,345 | 29 | 81 | 59 | 0.1% |
| Q3 2024 | 216 | $3.7B | 126,990,092 | 34 | 75 | 60 | 0.1% |
| Q2 2024 | 205 | $2.9B | 124,472,667 | 31 | 82 | 56 | 0.3% |
| Q1 2024 | 211 | $2.6B | 124,436,583 | 36 | 71 | 69 | 0.2% |
| Q4 2023 | 211 | $2.5B | 116,589,753 | 30 | 71 | 65 | 0.1% |
| Q3 2023 | 197 | $2.2B | 108,726,927 | 29 | 68 | 52 | 0.1% |
| Q2 2023 | 202 | $3.2B | 108,005,373 | 27 | 81 | 54 | 0.1% |
| Q1 2023 | 199 | $2.5B | 109,164,051 | 26 | 89 | 46 | 0.5% |
| Q4 2022 | 198 | $2.9B | 105,896,841 | 25 | 74 | 60 | 0.1% |
| Q3 2022 | 188 | $6.7B | 218,658,958 | 31 | 69 | 48 | 0.1% |
| Q2 2022 | 174 | $6.4B | 217,263,566 | 24 | 61 | 53 | 0.0% |
| Q1 2022 | 176 | $6.8B | 211,018,611 | 16 | 62 | 57 | 0.0% |
| Q4 2021 | 205 | $8.4B | 188,240,019 | 21 | 82 | 54 | 0.2% |
| Q3 2021 | 210 | $7.1B | 140,995,837 | 31 | 75 | 60 | 0.2% |
| Q2 2021 | 208 | $10.8B | 137,684,590 | 34 | 75 | 60 | 0.3% |
| Q1 2021 | 213 | $7.5B | 131,836,976 | 39 | 77 | 66 | 0.3% |
| Q4 2020 | 204 | $7.9B | 108,577,314 | 56 | 58 | 64 | 0.6% |
| Q3 2020 | 169 | $8.8B | 244,456,398 | 43 | 47 | 48 | 0.1% |
| Q2 2020 | 142 | $5.9B | 244,480,896 | 31 | 51 | 34 | 0.0% |
| Q1 2020 | 126 | $2.7B | 156,620,619 | 32 | 49 | 21 | 0.0% |
| Q4 2019 | 107 | $4.0B | 229,333,238 | 13 | 28 | 35 | 0.1% |
| Q3 2019 | 112 | $13.5B | 879,210,527 | 17 | 36 | 23 | 0.0% |
| Q2 2019 | 112 | $13.1B | 629,036,613 | 23 | 40 | 20 | 0.0% |
| Q1 2019 | 112 | $2.9B | 127,023,291 | 33 | 29 | 26 | 0.0% |
| Q4 2018 | 87 | $2.0B | 97,205,968 | 0 | 1 | 2 | 0.0% |