DaveManuel.com · Institutional Ownership · Who Owns It
DESIGN THERAPEUTICS INC (DSGN)
Institutional ownership reported to the SEC as of Q2 2026, across 23 quarters.
137
Reporting holders
$649.4M
Reported value
69.2%
Of shares outstanding
3.5%
Calls
0.0%
Puts
+12
Holder change
Institutions report 43,308,228 shares against 62,581,651 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| SR One Capital Management, LP | $94.4M | 6,526,476 | 9.09% | 19q | HELD |
| Logos Global Management LP | $43.4M | 3,000,000 | 1.87% | 22q | +53.8%+$15.2M |
| BAKER BROS. ADVISORS LP | $38.8M | 2,678,430 | 0.19% | 22q | +3.6%+$1.3M |
| Driehaus Capital Management LLC | $38.5M | 2,661,115 | 0.22% | 7q | +52.5%+$13.3M |
| BlackRock, Inc. | $38.5M | 2,660,024 | 0.00% | 8q | +24.7%+$7.6M |
| Caption Management, LLC | $37.9M incl. $21.7M options CALL | 1,118,098 | 0.18% | 3q | +1189.5%+$34.9M |
| Point72 Asset Management, L.P. | $34.2M | 2,366,453 | 0.04% | 10q | -13.1%-$5.2M |
| Trails Edge Capital Partners, LP | $29.0M | 2,001,282 | 4.60% | 2q | +134.9%+$16.6M |
| Frazier Life Sciences Management, L.P. | $26.2M | 1,809,854 | 0.57% | new | NEW |
| Vivo Capital, LLC | $23.3M | 1,612,903 | 2.13% | 3q | HELD |
| VANGUARD CAPITAL MANAGEMENT LLC | $22.7M | 1,571,022 | 0.00% | 2q | +16.4%+$3.2M |
| Almitas Capital LLC | $14.9M | 1,026,893 | 3.56% | 11q | -32.9%-$7.3M |
| GEODE CAPITAL MANAGEMENT, LLC | $13.9M | 958,417 | 0.00% | 22q | +38.4%+$3.8M |
| Sofinnova Investments, Inc. | $12.5M | 865,135 | 0.65% | new | NEW |
| FMR LLC | $11.2M | 776,462 | 0.00% | 22q | -2.7%-$317.6K |
| MORGAN STANLEY | $11.1M | 765,425 | 0.00% | 21q | +16.6%+$1.6M |
| STATE STREET CORP | $10.7M | 736,221 | 0.00% | 21q | +11.6%+$1.1M |
| Woodline Partners LP | $10.1M | 700,354 | 0.03% | 6q | -27.2%-$3.8M |
| DIMENSIONAL FUND ADVISORS LP | $10.1M | 694,743 | 0.00% | 17q | +60.9%+$3.8M |
| GOLDMAN SACHS GROUP INC | $9.5M | 656,584 | 0.00% | 22q | +30.1%+$2.2M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $8.2M | 565,597 | 0.03% | 3q | +95.4%+$4.0M |
| ACADIAN ASSET MANAGEMENT LLC | $7.8M | 537,479 | 0.01% | 11q | -12.8%-$1.1M |
| Siren, L.L.C. | $7.6M | 523,212 | 0.15% | new | NEW |
| Qube Research & Technologies Ltd | $6.3M | 437,079 | 0.01% | 2q | +1178.6%+$5.8M |
| RENAISSANCE TECHNOLOGIES LLC | $5.6M | 387,913 | 0.01% | 14q | -5.0%-$293.6K |
| KENNEDY CAPITAL MANAGEMENT LLC | $5.6M | 384,036 | 0.10% | 7q | +41.4%+$1.6M |
| NORTHERN TRUST CORP | $5.1M | 353,197 | 0.00% | 21q | +17.6%+$765.7K |
| ALGERT GLOBAL LLC | $4.3M | 296,085 | 0.05% | 3q | +44.6%+$1.3M |
| ACUTA CAPITAL PARTNERS, LLC | $4.1M | 282,564 | 2.85% | 3q | +93.7%+$2.0M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3.9M | 271,264 | 0.00% | 21q | +12.3%+$430.9K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3.6M | 251,442 | 0.00% | 2q | +81.5%+$1.6M |
| VANGUARD FIDUCIARY TRUST CO | $3.3M | 230,202 | 0.00% | 2q | +17.7%+$499.9K |
| PRUDENTIAL FINANCIAL INC | $3.2M | 224,170 | 0.00% | 13q | +389.3%+$2.6M |
| D. E. Shaw & Co., Inc. | $2.8M | 195,645 | 0.00% | 14q | -58.4%-$4.0M |
| Eversept Partners, LP | $2.7M | 190,000 | 0.14% | new | NEW |
| KVP Capital Advisors, LP | $2.7M | 185,000 | 1.96% | new | NEW |
| J. Goldman & Co LP | $2.6M | 176,770 | 0.07% | new | NEW |
| MILLENNIUM MANAGEMENT LLC | $2.1M | 147,714 | 0.00% | 4q | +35.6%+$561.2K |
| RAYMOND JAMES FINANCIAL INC | $2.0M | 138,521 | 0.00% | 3q | +27.7%+$435.1K |
| Balyasny Asset Management L.P. | $1.6M | 111,103 | 0.00% | new | NEW |
| Elmind Capital, LP | $1.6M | 107,900 | 0.39% | 3q | -48.1%-$1.4M |
| Nuveen, LLC | $1.5M | 104,734 | 0.00% | 6q | -17.4%-$319.5K |
| DAFNA Capital Management LLC | $1.5M | 102,600 | 0.28% | new | NEW |
| CITADEL ADVISORS LLC | $1.4M incl. $201.1K options CALL | 81,971 | 0.00% | 22q | -64.6%-$2.5M |
| Bank of New York Mellon Corp | $1.3M | 92,069 | 0.00% | 21q | +15.6%+$179.8K |
| China Universal Asset Management Co., Ltd. | $1.3M | 89,940 | 0.08% | 7q | +156.2%+$793.4K |
| SummitTX Capital, L.P. | $1.2M | 80,663 | 0.03% | new | NEW |
| AMERICAN CENTURY COMPANIES INC | $1.1M | 76,825 | 0.00% | 9q | +17.0%+$161.9K |
| Palumbo Wealth Management LLC | $1.0M | 71,744 | 0.22% | 10q | HELD |
| AQR CAPITAL MANAGEMENT LLC | $1.0M | 71,114 | 0.00% | 11q | +174.0%+$653.4K |
| AMERIPRISE FINANCIAL INC | $978.1K | 67,598 | 0.00% | 3q | +93.2%+$471.8K |
| Russell Investments Group, Ltd. | $967.4K | 66,859 | 0.00% | 17q | +162.8%+$599.4K |
| ALPS ADVISORS INC | $917.3K | 63,391 | 0.00% | 3q | +26.3%+$190.7K |
| STATE OF WISCONSIN INVESTMENT BOARD | $857.3K | 59,249 | 0.00% | 6q | +20.4%+$145.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $805.3K incl. $578.8K options CALL | 15,650 | 0.00% | new | NEW |
| STRS OHIO | $730.7K | 50,500 | 0.00% | 12q | +13.0%+$83.9K |
| Verdad Advisers, LP | $688.1K | 47,557 | 0.66% | 2q | -48.5%-$647.6K |
| BANK OF AMERICA CORP /DE/ | $632.7K | 43,728 | 0.00% | 22q | +88.0%+$296.1K |
| ExodusPoint Capital Management, LP | $597.4K | 41,286 | 0.00% | new | NEW |
| RHUMBLINE ADVISERS | $551.8K | 38,132 | 0.00% | 20q | +9.4%+$47.3K |
| Vanguard Global Advisers, LLC | $514.2K | 35,534 | 0.00% | 2q | +200.1%+$342.9K |
| UBS Group AG | $503.0K | 34,761 | 0.00% | 15q | +103.4%+$255.7K |
| Susquehanna Portfolio Strategies, LLC | $482.9K | 33,375 | 0.01% | new | NEW |
| TWO SIGMA INVESTMENTS, LP | $476.4K | 32,925 | 0.00% | 15q | +102.0%+$240.6K |
| CANADA PENSION PLAN INVESTMENT BOARD | $471.7K | 32,600 | 0.00% | 3q | -46.0%-$402.3K |
| OPPENHEIMER & CO INC | $464.3K | 32,087 | 0.00% | new | NEW |
| ALLIANCEBERNSTEIN L.P. | $460.0K | 43,230 | 0.00% | 17q | -6.3%-$30.7K |
| DEUTSCHE BANK AG\ | $443.0K | 30,613 | 0.00% | 3q | +48.3%+$144.3K |
| Virtus Investment Advisers, LLC | $431.6K | 29,827 | 0.10% | new | NEW |
| Squarepoint Ops LLC | $428.7K | 29,630 | 0.00% | 3q | -65.6%-$817.4K |
| Trexquant Investment LP | $407.3K | 28,150 | 0.00% | 3q | -76.0%-$1.3M |
| WELLS FARGO & COMPANY/MN | $406.2K | 28,072 | 0.00% | 14q | +211.0%+$275.6K |
| GROUP ONE TRADING LLC | $400.8K CALL | options only | 0.00% | 2q | OPTIONS |
| Corient Private Wealth LP | $393.1K | 27,169 | 0.00% | 3q | HELD |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $390.7K | 27,000 | 0.01% | 12q | -48.1%-$361.8K |
| Quantinno Capital Management LP | $389.3K | 26,901 | 0.00% | 2q | +90.4%+$184.8K |
| PRICE T ROWE ASSOCIATES INC /MD/ | $371.0K | 25,606 | 0.00% | 10q | +56.4%+$133.8K |
| SEI INVESTMENTS CO | $329.1K | 22,740 | 0.00% | 3q | -82.9%-$1.6M |
| XTX Topco Ltd | $323.9K | 22,383 | 0.00% | 4q | -63.3%-$557.9K |
| AlphaCentric Advisors LLC | $311.6K | 21,537 | 0.26% | 3q | +1.4%+$4.4K |
| Invesco Ltd. | $310.1K | 21,429 | 0.00% | 7q | -84.9%-$1.7M |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $299.5K | 20,700 | 0.00% | 3q | +36.2%+$79.7K |
| MetLife Investment Management, LLC | $298.2K | 20,609 | 0.00% | 4q | +35.1%+$77.6K |
| WELLINGTON MANAGEMENT GROUP LLP | $280.7K | 19,400 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $240.7K | 16,904 | 0.00% | 21q | +19.6%+$39.4K |
| CITIGROUP INC | $229.8K | 15,880 | 0.00% | 21q | +272.5%+$168.1K |
| Creative Planning | $229.3K | 15,844 | 0.00% | new | NEW |
| NISA INVESTMENT ADVISORS, LLC | $214.5K | 14,824 | 0.00% | 12q | HELD |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $205.1K | 14,171 | 0.00% | 9q | +24.7%+$40.6K |
| Y-Intercept (Hong Kong) Ltd | $186.8K | 12,910 | 0.00% | new | NEW |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $181.6K | 12,553 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $178.0K | 12,254 | 0.00% | 21q | +7.8%+$12.9K |
| BARCLAYS PLC | $169.4K | 11,707 | 0.00% | 18q | -79.0%-$637.9K |
| NEW YORK STATE COMMON RETIREMENT FUND | $156.7K | 10,826 | 0.00% | 21q | +434.4%+$127.3K |
| CAZ INVESTMENTS LP | $151.9K | 10,500 | 0.01% | 9q | +200.0%+$101.3K |
| GSA CAPITAL PARTNERS LLP | $149.0K | 10,328 | 0.01% | new | NEW |
| Police & Firemen's Retirement System of New Jersey | $142.5K | 9,849 | 0.00% | 7q | +49.3%+$47.0K |
| BNP PARIBAS FINANCIAL MARKETS | $83.2K | 5,751 | 0.00% | 7q | -88.6%-$644.2K |
| Clearstead Advisors, LLC | $81.2K | 5,610 | 0.00% | 14q | +819.7%+$72.4K |
| Tower Research Capital LLC (TRC) | $71.0K | 4,908 | 0.00% | 22q | +217.7%+$48.7K |
Showing the largest 100 of 137 reported holders.
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 22 | $2.6M | 208,747 | 3 | 10 | 4 | 0.0% |
| Q2 2026 | 137 | $649.4M | 43,308,228 | 30 | 61 | 32 | 3.5% |
| Q1 2026 | 125 | $404.1M | 37,986,614 | 18 | 53 | 28 | 0.0% |
| Q4 2025 | 118 | $362.6M | 38,145,985 | 29 | 38 | 28 | 1.3% |
| Q3 2025 | 96 | $271.4M | 36,046,220 | 15 | 17 | 38 | 0.0% |
| Q2 2025 | 93 | $116.4M | 34,534,256 | 8 | 32 | 33 | 0.0% |
| Q1 2025 | 96 | $133.0M | 34,459,504 | 14 | 23 | 33 | 0.0% |
| Q4 2024 | 94 | $206.5M | 33,460,900 | 12 | 33 | 21 | 0.0% |
| Q3 2024 | 99 | $172.7M | 32,072,745 | 16 | 27 | 31 | 0.1% |
| Q2 2024 | 92 | $124.5M | 37,143,905 | 13 | 35 | 26 | 0.1% |
| Q1 2024 | 90 | $127.9M | 31,722,195 | 18 | 21 | 35 | 0.0% |
| Q4 2023 | 87 | $86.2M | 32,301,997 | 15 | 34 | 23 | 0.7% |
| Q3 2023 | 86 | $78.1M | 32,867,865 | 15 | 26 | 34 | 0.7% |
| Q2 2023 | 97 | $244.4M | 38,786,588 | 12 | 29 | 41 | 0.0% |
| Q1 2023 | 98 | $230.2M | 39,649,821 | 32 | 24 | 23 | 0.6% |
| Q4 2022 | 84 | $421.2M | 40,368,316 | 22 | 26 | 23 | 1.7% |
| Q3 2022 | 77 | $733.7M | 43,343,709 | 19 | 30 | 17 | 1.2% |
| Q2 2022 | 70 | $571.9M | 40,655,813 | 17 | 25 | 13 | 0.5% |
| Q1 2022 | 60 | $642.1M | 39,749,163 | 5 | 27 | 15 | 0.0% |
| Q4 2021 | 59 | $945.0M | 44,199,294 | 11 | 27 | 5 | 0.0% |
| Q3 2021 | 52 | $414.8M | 28,281,317 | 3 | 20 | 11 | 0.0% |
| Q2 2021 | 50 | $546.2M | 27,839,146 | 18 | 13 | 6 | 0.0% |
| Q1 2021 | 43 | $755.2M | 25,762,953 | 42 | 0 | 0 | 0.0% |