DaveManuel.com · Institutional Ownership · Who Owns It
STRUCTURE THERAPEUTICS INC (GPCR)
Institutional ownership reported to the SEC as of Q2 2026, across 15 quarters.
197
Reporting holders
$3.7B
Reported value
31.6%
Of shares outstanding
0.7%
Calls
0.3%
Puts
-6
Holder change
Institutions report 67,601,728 shares against 213,929,572 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $419.2M | 7,810,306 | 0.02% | 14q | -7.1%-$31.8M |
| WELLINGTON MANAGEMENT GROUP LLP | $396.1M | 7,379,433 | 0.07% | 14q | +1.6%+$6.4M |
| Avoro Capital Advisors LLC | $351.8M | 6,555,555 | 3.16% | 4q | HELD |
| Jupiter Topco LLC | $279.3M | 5,204,212 | 0.11% | new | FIRST |
| Deep Track Capital, LP | $254.4M | 4,740,072 | 3.70% | 14q | +10.8%+$24.7M |
| BVF INC/IL | $180.7M | 3,366,823 | 4.62% | 14q | -2.7%-$5.0M |
| MORGAN STANLEY | $150.6M | 2,806,640 | 0.01% | 12q | +21.7%+$26.9M |
| ORBIMED ADVISORS LLC | $118.6M | 2,209,400 | 2.20% | 9q | +49.7%+$39.4M |
| PRINCIPAL FINANCIAL GROUP INC | $94.1M | 1,752,753 | 0.05% | 9q | HELD |
| AMERICAN CENTURY COMPANIES INC | $90.3M | 1,682,179 | 0.04% | 10q | +17.0%+$13.1M |
| RTW INVESTMENTS, LP | $86.3M | 1,607,507 | 0.74% | new | NEW |
| Driehaus Capital Management LLC | $83.4M | 1,553,219 | 0.48% | 14q | -1.5%-$1.3M |
| BAKER BROS. ADVISORS LP | $76.9M | 1,432,529 | 0.39% | 8q | HELD |
| Casdin Capital, LLC | $63.1M | 1,175,000 | 3.16% | 14q | HELD |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $58.3M | 1,086,000 | 0.61% | 14q | +41.4%+$17.1M |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $55.9M | 1,041,100 | 0.24% | 2q | -9.6%-$5.9M |
| Siren, L.L.C. | $46.9M | 872,967 | 0.95% | 4q | -34.3%-$24.5M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $45.4M | 845,532 | 0.00% | 14q | -57.7%-$62.0M |
| Pacific Heights Asset Management LLC | $42.9M | 800,000 | 1.36% | 5q | +6.7%+$2.7M |
| Rock Springs Capital Management LP | $34.4M | 640,317 | 1.68% | 11q | HELD |
| Aberdeen Group plc | $34.3M | 639,915 | 0.05% | 9q | +63.3%+$13.3M |
| FRANKLIN RESOURCES INC | $31.1M | 578,839 | 0.01% | 14q | +8.9%+$2.5M |
| BANK OF AMERICA CORP /DE/ | $30.2M | 563,422 | 0.00% | 13q | +148.1%+$18.0M |
| ALLIANCEBERNSTEIN L.P. | $29.5M | 611,708 | 0.01% | 5q | -4.2%-$1.3M |
| BlackRock, Inc. | $27.4M | 511,149 | 0.00% | 8q | +15.7%+$3.7M |
| Logos Global Management LP | $26.8M | 500,000 | 1.16% | 14q | HELD |
| Parkman Healthcare Partners LLC | $26.1M | 485,661 | 2.67% | 3q | +109.3%+$13.6M |
| Davern Capital Partners, LP | $23.9M | 446,059 | 4.08% | 2q | +252.7%+$17.2M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $22.5M | 418,800 | 0.03% | 3q | -10.5%-$2.6M |
| GOLDMAN SACHS GROUP INC | $20.8M incl. $7.8M options CALL | 242,790 | 0.00% | 12q | -6.8%-$1.5M |
| UBS Group AG | $20.3M | 378,986 | 0.00% | 11q | +78.0%+$8.9M |
| DEUTSCHE BANK AG\ | $17.8M | 331,867 | 0.01% | 3q | HELD |
| NEXTBio Capital Management LP | $16.8M | 312,496 | 7.71% | 3q | +134.5%+$9.6M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $15.7M incl. $9.2M options CALL+PUT | 122,344 | 0.00% | 11q | +119.1%+$8.6M |
| Catalio Capital Management, LP | $14.8M | 276,550 | 2.79% | 7q | +8.3%+$1.1M |
| MARSHALL WACE, LLP | $14.4M | 267,592 | 0.01% | 3q | +287.2%+$10.7M |
| HSG Holding Ltd | $14.3M | 266,062 | 1.19% | 12q | HELD |
| SEB Asset Management AB | $13.2M | 245,043 | 0.05% | 2q | HELD |
| AMERIPRISE FINANCIAL INC | $12.4M | 230,514 | 0.00% | 11q | +5.0%+$590.3K |
| NATIONAL BANK OF CANADA /FI/ | $11.6M | 215,800 | 0.01% | 8q | -29.3%-$4.8M |
| TWO SIGMA INVESTMENTS, LP | $11.0M | 204,156 | 0.01% | 4q | +12.5%+$1.2M |
| Eversept Partners, LP | $10.5M | 196,302 | 0.55% | 5q | +42.2%+$3.1M |
| Schonfeld Strategic Advisors LLC | $10.2M | 190,685 | 0.04% | 3q | +15.3%+$1.4M |
| Woodline Partners LP | $8.3M | 153,808 | 0.03% | 14q | -19.4%-$2.0M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $8.2M | 153,119 | 0.01% | 3q | +14.3%+$1.0M |
| ArrowMark Colorado Holdings LLC | $8.1M | 150,579 | 0.34% | 14q | -20.0%-$2.0M |
| Susquehanna Portfolio Strategies, LLC | $8.0M | 148,948 | 0.13% | 5q | +146.1%+$4.7M |
| CenterBook Partners LP | $7.9M | 148,030 | 0.39% | 2q | +597.0%+$6.8M |
| Rhenman & Partners Asset Management AB | $7.8M | 145,100 | 0.74% | 6q | +13.3%+$912.4K |
| B Group, Inc. | $7.5M | 140,000 | 3.53% | 3q | +9.8%+$670.9K |
| HighVista Strategies LLC | $7.0M | 130,784 | 1.60% | 12q | +5.5%+$369.0K |
| CITADEL ADVISORS LLC | $6.9M CALL+PUT | options only | 0.00% | 14q | OPTIONS |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $6.7M | 125,689 | 0.01% | 7q | +14.6%+$861.5K |
| Squarepoint Ops LLC | $6.7M | 125,575 | 0.01% | 2q | +454.5%+$5.5M |
| D. E. Shaw & Co., Inc. | $6.2M | 115,300 | 0.00% | 6q | -43.7%-$4.8M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $6.0M | 112,300 | 0.03% | 3q | -56.0%-$7.7M |
| Soleus Capital Management, L.P. | $5.7M | 107,000 | 0.20% | 3q | +33.8%+$1.4M |
| Avidity Partners Management LP | $5.3M | 98,000 | 0.84% | 2q | +25.6%+$1.1M |
| GEODE CAPITAL MANAGEMENT, LLC | $5.2M | 97,183 | 0.00% | 13q | +43.2%+$1.6M |
| Qube Research & Technologies Ltd | $5.0M | 93,403 | 0.00% | 2q | +26.9%+$1.1M |
| PEREGRINE CAPITAL MANAGEMENT LLC | $4.9M | 92,229 | 0.16% | 3q | -5.0%-$262.3K |
| PFM Health Sciences, LP | $4.9M | 91,550 | 0.42% | 6q | -27.6%-$1.9M |
| PLATINUM INVESTMENT MANAGEMENT LTD | $4.8M | 90,363 | 1.19% | 14q | +35.1%+$1.3M |
| MILLENNIUM MANAGEMENT LLC | $4.8M | 89,568 | 0.00% | 14q | -47.0%-$4.3M |
| ExodusPoint Capital Management, LP | $4.2M | 78,266 | 0.03% | new | NEW |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4.0M | 75,000 | 0.01% | new | NEW |
| Cormorant Asset Management, LP | $4.0M | 75,000 | 0.21% | 2q | -57.1%-$5.4M |
| Boxer Capital Management, LLC | $4.0M | 75,000 | 0.30% | 3q | HELD |
| ALPS ADVISORS INC | $3.9M | 71,833 | 0.02% | 7q | +24.6%+$760.3K |
| FLAX POND CAPITAL, LLC | $3.7M | 73,000 | 1.38% | 3q | +102.8%+$1.9M |
| TD Asset Management Inc | $3.7M | 68,962 | 0.00% | 14q | -66.3%-$7.3M |
| JANE STREET GROUP, LLC | $3.5M CALL+PUT | options only | 0.00% | 11q | OPTIONS |
| IMC-Chicago, LLC | $3.3M incl. $2.9M options CALL+PUT | 8,618 | 0.00% | new | NEW |
| Brevan Howard Capital Management LP | $3.3M | 60,336 | 0.02% | 3q | +27.7%+$705.8K |
| Burkehill Global Management, LP | $3.2M | 60,000 | 0.12% | 3q | HELD |
| RAYMOND JAMES FINANCIAL INC | $3.2M | 59,357 | 0.00% | 3q | +31.5%+$763.1K |
| TUDOR INVESTMENT CORP ET AL | $3.1M incl. $214.7K options CALL | 53,656 | 0.00% | 3q | -28.7%-$1.2M |
| ANTIPODES PARTNERS Ltd | $2.8M | 51,262 | 0.05% | 9q | +13.0%+$316.7K |
| SCOGGIN MANAGEMENT LP | $2.7M CALL | options only | 0.29% | new | OPTIONS |
| SEVEN GRAND MANAGERS, LLC | $2.7M | 50,000 | 0.11% | 3q | HELD |
| Buckland Partners Management Co LLC | $2.7M | 50,000 | 1.31% | 3q | HELD |
| DAFNA Capital Management LLC | $2.5M | 46,500 | 0.48% | 9q | HELD |
| Mariner, LLC | $2.5M | 46,285 | 0.00% | 7q | +34.2%+$633.6K |
| OSAIC HOLDINGS, INC. | $2.4M | 44,786 | 0.00% | 12q | +0.8%+$19.9K |
| STATE STREET CORP | $2.4M | 44,629 | 0.00% | 13q | -6.2%-$158.4K |
| VOYA INVESTMENT MANAGEMENT LLC | $2.4M | 44,410 | 0.00% | 9q | HELD |
| BANQUE PICTET & CIE SA | $2.3M | 43,332 | 0.01% | 8q | -12.2%-$323.9K |
| Jump Financial, LLC | $2.3M | 42,658 | 0.02% | 2q | -60.4%-$3.5M |
| BANK OF MONTREAL /CAN/ | $2.3M | 42,570 | 0.00% | 9q | +6.5%+$138.8K |
| Cinctive Capital Management LP | $2.2M | 40,877 | 0.08% | 2q | +369.1%+$1.7M |
| Jefferies Financial Group Inc. | $2.2M | 40,625 | 0.01% | 4q | -35.1%-$1.2M |
| Jones Hill Capital LP | $2.2M | 40,567 | 0.46% | 2q | -59.7%-$3.2M |
| STEMPOINT CAPITAL LP | $2.0M | 38,178 | 0.35% | 4q | -90.5%-$19.4M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2.0M | 38,108 | 0.00% | 13q | -66.8%-$4.1M |
| CAPITAL FUND MANAGEMENT S.A. | $2.0M | 37,281 | 0.01% | 2q | +14.9%+$260.0K |
| PSquared Asset Management AG | $2.0M | 37,200 | 0.65% | 2q | +6.3%+$118.1K |
| TrueMark Investments, LLC | $1.8M | 33,600 | 0.23% | 11q | -2.3%-$41.7K |
| NOMURA ASSET MANAGEMENT CO LTD | $1.8M | 32,790 | 0.00% | 10q | HELD |
| DCF Advisers, LLC | $1.7M | 32,100 | 0.30% | 3q | +16.7%+$246.9K |
| EXCHANGE TRADED CONCEPTS, LLC | $1.7M | 30,773 | 0.01% | 9q | +21.3%+$289.5K |
Showing the largest 100 of 197 reported holders.
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 22 | $4.7M | 149,313 | 3 | 10 | 3 | 0.0% |
| Q2 2026 | 197 | $3.7B | 67,601,728 | 30 | 75 | 50 | 1.0% |
| Q1 2026 | 203 | $3.3B | 67,064,965 | 38 | 73 | 59 | 1.4% |
| Q4 2025 | 201 | $4.7B | 65,784,642 | 65 | 51 | 62 | 1.7% |
| Q3 2025 | 159 | $1.6B | 56,708,213 | 23 | 57 | 48 | 3.1% |
| Q2 2025 | 174 | $1.2B | 54,670,216 | 37 | 59 | 44 | 2.0% |
| Q1 2025 | 152 | $1.0B | 55,959,678 | 22 | 44 | 49 | 2.4% |
| Q4 2024 | 167 | $1.7B | 60,660,247 | 19 | 62 | 49 | 2.7% |
| Q3 2024 | 162 | $2.7B | 61,592,764 | 25 | 65 | 36 | 1.5% |
| Q2 2024 | 173 | $2.5B | 60,393,184 | 58 | 63 | 33 | 3.9% |
| Q1 2024 | 128 | $2.0B | 44,254,364 | 30 | 43 | 35 | 4.1% |
| Q4 2023 | 124 | $1.8B | 42,880,996 | 56 | 36 | 24 | 5.1% |
| Q3 2023 | 84 | $1.6B | 32,794,322 | 42 | 28 | 6 | 0.0% |
| Q2 2023 | 48 | $699.4M | 17,647,287 | 14 | 11 | 10 | 0.0% |
| Q1 2023 | 40 | $375.9M | 16,008,304 | 39 | 0 | 0 | 0.0% |