DaveManuel.com · Institutional Ownership · Who Owns It
IONIS PHARMACEUTICALS INC (IONS)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
525
Reporting holders
$14.9B
Reported value
108.2%
Of shares outstanding
2.6%
Calls
1.7%
Puts
+22
Holder change
Institutions report 179,786,529 shares against 166,184,322 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $2.0B | 24,631,956 | 0.08% | 31q | HELD |
| Capital World Investors | $1.7B | 21,669,226 | 0.20% | 13q | +2.3%+$38.3M |
| BlackRock, Inc. | $848.8M | 10,704,660 | 0.01% | 8q | +2.5%+$20.8M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $623.2M | 7,859,529 | 0.03% | 2q | +0.6%+$4.0M |
| WELLINGTON MANAGEMENT GROUP LLP | $606.7M | 7,651,415 | 0.10% | 13q | +19.7%+$99.9M |
| VANGUARD CAPITAL MANAGEMENT LLC | $571.8M | 7,211,497 | 0.01% | 2q | +1.3%+$7.4M |
| TWO SIGMA INVESTMENTS, LP | $495.7M | 6,252,342 | 0.36% | 31q | +6.7%+$31.3M |
| ROYAL BANK OF CANADA | $490.2M | 6,182,479 | 0.07% | 31q | +62.6%+$188.8M |
| STATE STREET CORP | $343.7M | 4,334,848 | 0.01% | 31q | +8.5%+$26.9M |
| T. Rowe Price Investment Management, Inc. | $313.9M | 3,959,372 | 0.21% | 16q | -35.7%-$174.4M |
| GEODE CAPITAL MANAGEMENT, LLC | $294.8M | 3,584,024 | 0.02% | 31q | -10.0%-$32.9M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $252.5M | 3,184,500 | 0.03% | 31q | +5.3%+$12.6M |
| JPMORGAN CHASE & CO | $242.8M incl. $26.6M options CALL+PUT | 2,671,717 | 0.01% | 31q | +13.0%+$28.0M |
| Artisan Partners Limited Partnership | $209.3M | 2,640,024 | 0.33% | 10q | +28.3%+$46.1M |
| Tweedy, Browne Co LLC | $180.8M | 2,280,311 | 13.70% | 18q | HELD |
| Deep Track Capital, LP | $174.4M | 2,200,000 | 2.54% | 15q | +12.8%+$19.8M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $168.6M incl. $168.3M options CALL+PUT | 3,839 | 0.01% | 31q | -68.9%-$374.2M |
| GOLDMAN SACHS GROUP INC | $167.3M | 2,109,945 | 0.01% | 31q | +24.1%+$32.5M |
| BAKER BROS. ADVISORS LP | $162.4M | 2,047,727 | 0.81% | 4q | HELD |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $157.0M | 1,979,669 | 1.64% | 4q | HELD |
| AMERICAN CENTURY COMPANIES INC | $154.4M | 1,947,076 | 0.07% | 6q | +17.0%+$22.5M |
| BARCLAYS PLC | $131.1M incl. $4.0M options PUT | 1,603,136 | 0.03% | 31q | +453.0%+$107.4M |
| FRANKLIN RESOURCES INC | $128.7M | 1,623,377 | 0.03% | 5q | +3.1%+$3.8M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $127.3M | 1,605,054 | 0.02% | 31q | +1.4%+$1.7M |
| JANE STREET GROUP, LLC | $127.1M incl. $87.1M options CALL+PUT | 503,647 | 0.01% | 31q | +162.6%+$78.7M |
| Pictet Asset Management Holding SA | $127.0M | 1,596,998 | 0.12% | 12q | +11.3%+$12.9M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $115.3M | 1,454,672 | 0.02% | 31q | -1.4%-$1.7M |
| Polar Capital Holdings Plc | $115.3M | 1,454,021 | 0.27% | 5q | +75.3%+$49.5M |
| Alyeska Investment Group, L.P. | $112.4M | 1,417,916 | 0.29% | 5q | +199.7%+$74.9M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $103.1M | 1,300,392 | 0.15% | 3q | +65.6%+$40.8M |
| MORGAN STANLEY | $101.6M | 1,281,444 | 0.01% | 35q | +24.8%+$20.2M |
| Invesco Ltd. | $88.9M | 1,120,707 | 0.01% | 31q | -12.3%-$12.4M |
| VANGUARD FIDUCIARY TRUST CO | $84.1M | 1,060,845 | 0.02% | 2q | +3.6%+$2.9M |
| Caption Management, LLC | $77.5M incl. $77.4M options CALL+PUT | 1,759 | 0.36% | 9q | -88.7%-$609.6M |
| Bellevue Group AG | $77.1M | 972,258 | 1.62% | 31q | -46.5%-$67.1M |
| GROUPAMA ASSET MANAGMENT | $75.2M | 937,083 | 0.95% | 11q | +13.6%+$9.0M |
| NORTHERN TRUST CORP | $72.4M | 913,610 | 0.01% | 31q | +5.2%+$3.6M |
| CITADEL ADVISORS LLC | $67.8M incl. $49.1M options CALL+PUT | 236,284 | 0.01% | 31q | -74.9%-$202.7M |
| Capital International Investors | $65.3M | 823,764 | 0.01% | new | NEW |
| Davern Capital Partners, LP | $63.3M | 798,709 | 10.80% | 3q | +106.4%+$32.7M |
| BANK OF AMERICA CORP /DE/ | $62.7M | 790,990 | 0.00% | 31q | -5.9%-$3.9M |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | $62.4M | 787,263 | 1.10% | 4q | -43.9%-$48.9M |
| GW&K Investment Management, LLC | $59.2M | 746,966 | 0.46% | 7q | -4.2%-$2.6M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $58.2M | 734,219 | 0.06% | 11q | -19.1%-$13.7M |
| Nuveen, LLC | $57.6M | 726,282 | 0.01% | 6q | +12.0%+$6.2M |
| Ikarian Capital, LLC | $55.5M CALL+PUT | options only | 5.98% | 4q | OPTIONS |
| Connor, Clark & Lunn Investment Management Ltd. | $54.3M | 684,236 | 0.10% | 9q | -21.7%-$15.1M |
| Eversept Partners, LP | $52.7M | 664,684 | 2.73% | 21q | +5.2%+$2.6M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $52.0M | 655,454 | 0.22% | 8q | -2.6%-$1.4M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $51.7M | 651,816 | 0.02% | 5q | -2.1%-$1.1M |
| NEUBERGER BERMAN GROUP LLC | $50.2M | 633,533 | 0.03% | 17q | +42.9%+$15.1M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $50.1M | 632,028 | 0.02% | 4q | -14.3%-$8.4M |
| UBS Group AG | $49.5M | 624,874 | 0.01% | 31q | -22.7%-$14.6M |
| TimesSquare Capital Management, LLC | $48.7M | 614,070 | 0.72% | 2q | +122.8%+$26.8M |
| EVENTIDE ASSET MANAGEMENT, LLC | $45.6M | 575,000 | 0.61% | 3q | HELD |
| PERCEPTIVE ADVISORS LLC | $44.9M | 566,000 | 0.67% | 2q | +12.3%+$4.9M |
| RENAISSANCE TECHNOLOGIES LLC | $44.4M | 559,414 | 0.06% | 29q | +83.1%+$20.1M |
| MILLENNIUM MANAGEMENT LLC | $43.3M incl. $20.4M options CALL | 288,872 | 0.02% | 31q | -72.5%-$114.4M |
| Bank of New York Mellon Corp | $43.0M | 542,454 | 0.01% | 31q | +5.4%+$2.2M |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $41.4M | 522,317 | 0.11% | 29q | HELD |
| BOONE CAPITAL MANAGEMENT LLC | $41.2M | 519,977 | 9.64% | 4q | +3.9%+$1.5M |
| NEW YORK STATE COMMON RETIREMENT FUND | $39.6M | 500,050 | 0.05% | 31q | +42.7%+$11.9M |
| NOMURA HOLDINGS INC | $36.6M incl. $4.7M options CALL | 402,192 | 0.04% | 21q | +252.6%+$26.2M |
| BNP PARIBAS FINANCIAL MARKETS | $36.0M | 454,649 | 0.01% | 31q | -5.2%-$2.0M |
| Candriam S.C.A. | $35.3M | 445,019 | 0.16% | 31q | -8.1%-$3.1M |
| FIRST TRUST ADVISORS LP | $33.9M | 427,197 | 0.02% | 5q | -8.8%-$3.3M |
| PINNACLE ASSOCIATES LTD | $33.3M | 419,752 | 0.36% | 31q | -3.8%-$1.3M |
| D. E. Shaw & Co., Inc. | $30.5M incl. $6.9M options CALL | 297,041 | 0.01% | 4q | -30.9%-$13.6M |
| Handelsbanken Fonder AB | $30.4M | 383,211 | 0.09% | 25q | +79.1%+$13.4M |
| C WorldWide Group Holding A/S | $29.0M | 366,000 | 0.70% | 11q | HELD |
| TD Asset Management Inc | $27.0M | 340,548 | 0.02% | 31q | -35.7%-$15.0M |
| Freestone Grove Partners LP | $27.0M | 339,967 | 0.17% | new | NEW |
| Qube Research & Technologies Ltd | $26.5M | 333,952 | 0.02% | 2q | +679.2%+$23.1M |
| Capital Research Global Investors | $26.3M | 331,936 | 0.00% | 2q | +2.8%+$707.3K |
| CAPITAL FUND MANAGEMENT S.A. | $26.1M | 329,554 | 0.12% | 2q | +131.8%+$14.9M |
| ALLIANCEBERNSTEIN L.P. | $25.6M | 340,450 | 0.01% | 31q | -15.0%-$4.5M |
| Carmignac Gestion | $25.5M | 321,000 | 0.33% | 2q | +505.7%+$21.2M |
| Privium Fund Management B.V. | $25.4M | 319,924 | 4.66% | 19q | +10.3%+$2.4M |
| Swiss National Bank | $25.0M | 315,000 | 0.01% | 31q | +3.4%+$832.5K |
| Jump Financial, LLC | $24.3M | 306,330 | 0.20% | 2q | +48.2%+$7.9M |
| ARK Investment Management LLC | $23.8M | 300,770 | 0.15% | 31q | +4.2%+$955.8K |
| Integral Health Asset Management, LLC | $23.8M CALL | options only | 0.94% | 2q | OPTIONS |
| Legal & General Group Plc | $23.7M | 299,184 | 0.00% | 31q | +1.5%+$357.2K |
| DAVENPORT & Co LLC | $22.5M | 283,960 | 0.11% | 31q | +19.2%+$3.6M |
| Aberdeen Group plc | $22.0M | 277,400 | 0.03% | 11q | +143.7%+$13.0M |
| California Public Employees Retirement System | $21.5M | 270,843 | 0.01% | 31q | +6.0%+$1.2M |
| CITIGROUP INC | $20.3M incl. $13.4M options CALL+PUT | 86,746 | 0.01% | 31q | -40.8%-$14.0M |
| IMC-Chicago, LLC | $20.0M CALL+PUT | options only | 0.00% | 4q | OPTIONS |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | $20.0M incl. $79.3K options CALL | 251,215 | 0.26% | 31q | +14.6%+$2.5M |
| RAYMOND JAMES FINANCIAL INC | $18.8M | 237,348 | 0.01% | 7q | +0.9%+$176.6K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $18.5M | 233,499 | 0.03% | 6q | +6.3%+$1.1M |
| WELLS FARGO & COMPANY/MN | $17.9M | 226,213 | 0.00% | 31q | +19.2%+$2.9M |
| BOOTHBAY FUND MANAGEMENT, LLC | $17.7M incl. $16.8M options CALL+PUT | 11,808 | 0.23% | 4q | -84.6%-$97.2M |
| Empowered Funds, LLC | $17.7M | 223,142 | 0.09% | 2q | +116.3%+$9.5M |
| Orion Investment Co | $17.5M | 220,335 | 5.10% | 9q | -2.1%-$371.1K |
| Life Cycle Investment Partners Ltd | $17.4M | 219,896 | 0.08% | new | NEW |
| ALGERT GLOBAL LLC | $16.4M | 206,853 | 0.19% | 5q | +77.5%+$7.2M |
| STIFEL FINANCIAL CORP | $16.1M | 202,983 | 0.01% | 31q | +3.2%+$497.9K |
| Corient Private Wealth LP | $15.6M | 196,661 | 0.02% | 15q | HELD |
| Eagle Health Investments LP | $15.4M | 194,577 | 2.56% | new | NEW |
Showing the largest 100 of 526 reported holders. The count of 525 above leaves out 1 position whose reported value failed our price check; it is listed here as filed.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-06-12 | Kordasiewicz Holly B. | EVP, Chief Development Officer | Sold | 60,846 | $4.5M ×2 |
| 2026-06-26 | Monia Brett P | Chief Executive Officer | Sold | 50,000 | $4.0M |
| 2026-06-26 | Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Sold | 26,000 | $2.1M |
| 2026-07-07 | BENNETT C FRANK | EVP, Chief Scientific Officer | Sold | 20,536 | $1.7M ×2 |
| 2026-06-25 | Monia Brett P | Chief Executive Officer | Sold | 21,072 | $1.7M |
| 2026-06-24 | Monia Brett P | Chief Executive Officer | Sold | 14,565 | $1.1M |
| 2026-07-01 | KLEIN JOSEPH III | Director | Sold | 11,518 | $910.4K ×2 |
| 2026-07-07 | Diaz Allene M. | Director | Sold | 10,111 | $863.6K |
| 2026-06-25 | Swayze Eric | EVP Research | Sold | 10,602 | $839.5K |
| 2026-07-30 | Hayden Michael R | Director | Bought | 15,000 | $800.7K |
| 2026-06-01 | BERTHELSEN SPENCER R | Director | Sold | 8,000 | $605.4K |
| 2026-06-15 | BERTHELSEN SPENCER R | Director | Sold | 8,000 | $587.9K |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 103 | $81.7M | 1,829,355 | 18 | 31 | 28 | 0.1% |
| Q2 2026 | 525 | $14.9B | 179,786,529 | 63 | 194 | 163 | 4.3% |
| Q1 2026 | 503 | $13.3B | 172,601,492 | 65 | 171 | 152 | 2.2% |
| Q4 2025 | 501 | $14.2B | 176,289,537 | 91 | 161 | 136 | 1.8% |
| Q3 2025 | 448 | $11.3B | 169,217,819 | 118 | 125 | 116 | 2.2% |
| Q2 2025 | 371 | $6.8B | 170,150,936 | 78 | 113 | 109 | 1.5% |
| Q1 2025 | 351 | $5.1B | 167,283,270 | 51 | 99 | 119 | 0.9% |
| Q4 2024 | 364 | $5.7B | 160,973,542 | 45 | 117 | 113 | 1.0% |
| Q3 2024 | 358 | $6.4B | 158,619,886 | 49 | 127 | 102 | 1.0% |
| Q2 2024 | 361 | $7.1B | 144,640,984 | 48 | 111 | 131 | 2.3% |
| Q1 2024 | 364 | $6.4B | 145,439,906 | 47 | 117 | 118 | 1.3% |
| Q4 2023 | 368 | $7.4B | 145,041,814 | 66 | 103 | 104 | 1.0% |
| Q3 2023 | 317 | $6.4B | 140,183,536 | 38 | 93 | 93 | 0.8% |
| Q2 2023 | 311 | $5.6B | 136,546,459 | 36 | 90 | 100 | 0.8% |
| Q1 2023 | 315 | $5.5B | 153,132,926 | 32 | 83 | 120 | 0.5% |
| Q4 2022 | 339 | $5.0B | 130,590,691 | 46 | 104 | 113 | 0.6% |
| Q3 2022 | 342 | $20.2B | 455,329,253 | 50 | 88 | 122 | 0.2% |
| Q2 2022 | 340 | $17.2B | 462,508,289 | 51 | 84 | 121 | 0.2% |
| Q1 2022 | 325 | $12.6B | 433,213,563 | 45 | 101 | 103 | 0.3% |
| Q4 2021 | 335 | $17.8B | 887,282,344 | 42 | 101 | 110 | 0.3% |
| Q3 2021 | 320 | $21.7B | 669,433,112 | 32 | 98 | 98 | 0.3% |
| Q2 2021 | 334 | $25.3B | 633,010,769 | 50 | 109 | 97 | 0.3% |
| Q1 2021 | 356 | $7.9B | 173,451,245 | 47 | 124 | 106 | 1.1% |
| Q4 2020 | 380 | $8.0B | 139,016,020 | 49 | 112 | 103 | 1.9% |
| Q3 2020 | 365 | $9.8B | 249,933,371 | 38 | 105 | 123 | 0.7% |
| Q2 2020 | 374 | $12.6B | 275,124,358 | 49 | 114 | 125 | 0.7% |
| Q1 2020 | 362 | $7.7B | 232,540,257 | 33 | 101 | 133 | 1.0% |
| Q4 2019 | 385 | $18.0B | 293,904,594 | 43 | 107 | 124 | 1.1% |
| Q3 2019 | 367 | $12.6B | 207,842,387 | 40 | 109 | 115 | 1.5% |
| Q2 2019 | 391 | $14.0B | 212,064,314 | 61 | 158 | 90 | 2.2% |
| Q1 2019 | 397 | $14.6B | 176,529,702 | 94 | 97 | 126 | 2.3% |
| Q4 2018 | 325 | $7.2B | 129,643,677 | 2 | 4 | 8 | 2.5% |