KARYOPHARM THERAPEUTICS INC (KPTI)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
Institutions report 21,842,860 shares against 22,681,460 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $18.7M | 1,917,354 | 0.16% | 2q | HELD |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $14.9M | 1,521,322 | 0.02% | 6q | -15.8%-$2.8M |
| ACORN CAPITAL ADVISORS, LLC | $14.8M | 1,518,113 | 4.05% | 2q | +427.4%+$12.0M |
| GOLDMAN SACHS GROUP INC | $13.9M | 1,424,658 | 0.00% | 2q | +50.3%+$4.7M |
| BlackRock, Inc. | $13.9M | 1,418,799 | 0.00% | 6q | +479.3%+$11.5M |
| Kalehua Capital Management LLC | $13.4M | 1,371,288 | 4.27% | new | NEW |
| VANGUARD CAPITAL MANAGEMENT LLC | $9.4M | 958,979 | 0.00% | 2q | +29.6%+$2.1M |
| Catalio Capital Management, LP | $9.2M | 940,855 | 1.73% | 6q | +4.8%+$421.5K |
| Avidity Partners Management LP | $9.0M | 924,487 | 1.45% | 6q | HELD |
| T. Rowe Price Investment Management, Inc. | $7.7M | 786,309 | 0.01% | 6q | -49.0%-$7.4M |
| TWO SIGMA INVESTMENTS, LP | $6.8M | 695,264 | 0.00% | 3q | +359.7%+$5.3M |
| NEA Management Company, LLC | $5.6M | 576,780 | 0.35% | new | NEW |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5.3M CALL+PUT | options only | 0.00% | 6q | OPTIONS |
| GEODE CAPITAL MANAGEMENT, LLC | $5.2M | 531,231 | 0.00% | 6q | +157.7%+$3.2M |
| Ghisallo Capital Management LLC | $4.9M | 500,000 | 0.10% | new | NEW |
| Soleus Capital Management, L.P. | $4.3M | 440,000 | 0.15% | 3q | HELD |
| Caption Management, LLC | $3.7M CALL+PUT | options only | 0.02% | 2q | OPTIONS |
| UBS Group AG | $3.5M | 353,545 | 0.00% | 6q | +82.2%+$1.6M |
| MILLENNIUM MANAGEMENT LLC | $3.3M incl. $351.7K options PUT | 305,676 | 0.00% | 2q | -27.3%-$1.3M |
| STATE STREET CORP | $3.2M | 325,991 | 0.00% | 6q | +303.7%+$2.4M |
| Affinity Asset Advisors, LLC | $3.1M | 312,500 | 0.14% | 5q | -37.5%-$1.8M |
| Brevan Howard Capital Management LP | $3.0M | 309,817 | 0.02% | 2q | +45.9%+$952.1K |
| Boxer Capital Management, LLC | $3.0M | 302,536 | 0.22% | 3q | HELD |
| Davidson Kempner Capital Management LP | $2.9M | 300,000 | 0.03% | 3q | HELD |
| ACADIAN ASSET MANAGEMENT LLC | $2.9M | 298,997 | 0.00% | 3q | +20.1%+$488.0K |
| SILVERARC CAPITAL MANAGEMENT, LLC | $2.9M | 297,460 | 0.30% | new | NEW |
| Eversept Partners, LP | $2.7M | 276,174 | 0.14% | 2q | HELD |
| Tetragon Partners GP Ltd | $2.4M CALL | options only | 0.39% | 2q | OPTIONS |
| JPMORGAN CHASE & CO | $2.2M incl. $63.5K options CALL | 207,609 | 0.00% | 6q | +43978.3%+$2.2M |
| MORGAN STANLEY | $2.0M | 202,506 | 0.00% | 6q | +990.5%+$1.8M |
| Trexquant Investment LP | $1.8M | 188,368 | 0.01% | 3q | -27.0%-$679.4K |
| BNP PARIBAS FINANCIAL MARKETS | $1.8M | 188,038 | 0.00% | 6q | +223754.8%+$1.8M |
| DLD Asset Management, LP | $1.8M CALL+PUT | options only | 0.12% | new | OPTIONS |
| BARCLAYS PLC | $1.6M | 165,904 | 0.00% | 6q | +2134.7%+$1.5M |
| NORTHERN TRUST CORP | $1.6M | 160,006 | 0.00% | 6q | +315.0%+$1.2M |
| VANGUARD FIDUCIARY TRUST CO | $1.4M | 145,401 | 0.00% | 2q | +26.5%+$297.7K |
| J. Goldman & Co LP | $1.3M incl. $660.5K options PUT | 67,500 | 0.03% | new | NEW |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1.3M | 134,818 | 0.00% | new | NEW |
| SILVERBACK ASSET MANAGEMENT LLC | $1.3M incl. $977.0K options CALL | 30,000 | 0.14% | 6q | -53.8%-$1.5M |
| MARSHALL WACE, LLP | $1.3M | 128,451 | 0.00% | 6q | HELD |
| GROUP ONE TRADING LLC | $1.2M CALL+PUT | options only | 0.00% | 6q | OPTIONS |
| CITADEL ADVISORS LLC | $1.2M incl. $643.8K options CALL+PUT | 52,069 | 0.00% | 6q | HELD |
| RENAISSANCE TECHNOLOGIES LLC | $1.1M | 108,214 | 0.00% | 6q | +2.7%+$27.4K |
| C WorldWide Group Holding A/S | $977.0K | 100,000 | 0.02% | 6q | HELD |
| Jump Financial, LLC | $918.4K | 94,000 | 0.01% | 3q | -64.1%-$1.6M |
| Invesco Ltd. | $882.3K | 90,304 | 0.00% | 2q | +439.5%+$718.7K |
| JANE STREET GROUP, LLC | $842.9K incl. $518.8K options CALL+PUT | 33,173 | 0.00% | 4q | -68.7%-$1.8M |
| Connor, Clark & Lunn Investment Management Ltd. | $746.4K | 76,397 | 0.00% | 3q | -3.4%-$26.2K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $702.2K | 71,873 | 0.01% | 5q | HELD |
| Squarepoint Ops LLC | $623.3K | 63,801 | 0.00% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $605.2K | 61,943 | 0.00% | 2q | +361.3%+$474.0K |
| ROYAL BANK OF CANADA | $590.0K | 60,430 | 0.00% | 6q | HELD |
| Bank of New York Mellon Corp | $559.4K | 57,262 | 0.00% | 6q | +402.3%+$448.1K |
| Susquehanna Portfolio Strategies, LLC | $532.9K | 54,545 | 0.01% | 2q | +118.0%+$288.4K |
| XTX Topco Ltd | $520.5K | 53,272 | 0.01% | 5q | -67.6%-$1.1M |
| BANK OF AMERICA CORP /DE/ | $487.8K | 49,924 | 0.00% | 6q | +156.4%+$297.5K |
| Birchview Capital, LP | $419.6K | 42,952 | 0.20% | 2q | -48.8%-$400.6K |
| CITIGROUP INC | $370.4K | 37,917 | 0.00% | 6q | +667.4%+$322.2K |
| Nuveen, LLC | $370.0K | 37,868 | 0.00% | new | NEW |
| Engineers Gate Manager LP | $331.8K | 33,966 | 0.00% | 2q | -69.8%-$766.6K |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $326.0K | 33,333 | 0.00% | new | NEW |
| SIMPLEX TRADING, LLC | $323.2K incl. $87.9K options CALL+PUT | 24,086 | 0.00% | new | NEW |
| TORONTO DOMINION BANK | $302.2K | 30,930 | 0.00% | new | NEW |
| Baird Financial Group, Inc. | $291.1K | 29,791 | 0.00% | 5q | HELD |
| PRICE T ROWE ASSOCIATES INC /MD/ | $266.0K | 27,225 | 0.00% | 5q | +150.1%+$159.6K |
| ExodusPoint Capital Management, LP | $259.7K | 26,582 | 0.00% | new | NEW |
| China Universal Asset Management Co., Ltd. | $244.2K | 25,000 | 0.01% | 2q | -16.7%-$48.9K |
| RHUMBLINE ADVISERS | $229.3K | 23,467 | 0.00% | new | NEW |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $227.3K | 23,265 | 0.00% | new | NEW |
| Velan Capital Investment Management LP | $195.4K | 20,000 | 0.12% | 2q | +33.3%+$48.9K |
| DEUTSCHE BANK AG\ | $189.8K | 19,425 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $165.1K | 16,903 | 0.00% | new | NEW |
| SEI INVESTMENTS CO | $147.4K | 15,083 | 0.00% | new | NEW |
| HSBC HOLDINGS PLC | $137.4K | 13,750 | 0.00% | 2q | +19.6%+$22.5K |
| Headlands Technologies LLC | $118.3K | 12,113 | 0.01% | new | NEW |
| MetLife Investment Management, LLC | $117.4K | 12,017 | 0.00% | new | NEW |
| Virtu Financial LLC | $105.0K | 10,728 | 0.00% | new | NEW |
| Y-Intercept (Hong Kong) Ltd | $101.4K | 10,375 | 0.00% | new | NEW |
| Quadrature Capital Ltd | $100.6K | 10,296 | 0.00% | new | NEW |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $89.6K | 9,171 | 0.00% | new | NEW |
| FMR LLC | $87.3K | 8,936 | 0.00% | 6q | +1243.8%+$80.8K |
| Vanguard Global Advisers, LLC | $80.2K | 8,207 | 0.00% | 2q | HELD |
| Police & Firemen's Retirement System of New Jersey | $57.4K | 5,874 | 0.00% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $54.7K | 5,600 | 0.00% | new | NEW |
| TD Waterhouse Canada Inc. | $54.5K | 5,707 | 0.00% | 6q | +78.2%+$23.9K |
| Legal & General Group Plc | $18.9K | 1,935 | 0.00% | new | NEW |
| Ameritas Investment Partners, Inc. | $17.7K | 1,808 | 0.00% | new | NEW |
| Russell Investments Group, Ltd. | $15.6K | 1,592 | 0.00% | new | NEW |
| Tower Research Capital LLC (TRC) | $12.3K | 1,259 | 0.00% | new | NEW |
| OSAIC HOLDINGS, INC. | $3.9K | 402 | 0.00% | 6q | HELD |
| Sterling Capital Management LLC | $3.4K | 352 | 0.00% | new | NEW |
| HARBOUR INVESTMENTS, INC. | $2.8K | 285 | 0.00% | 6q | HELD |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2.7K | 274 | 0.00% | new | NEW |
| Quent Capital, LLC | $1.6K | 166 | 0.00% | 4q | -29.4% |
| MB, LEVIS & ASSOCIATES, LLC | $977 | 100 | 0.00% | 6q | HELD |
| SBI Securities Co., Ltd. | $655 | 67 | 0.00% | 6q | HELD |
| Activest Wealth Management | $645 | 66 | 0.00% | 6q | HELD |
| Allworth Financial LP | $255 | 26 | 0.00% | 6q | HELD |
| Caitong International Asset Management Co., Ltd | $137 | 14 | 0.00% | new | NEW |
| West Branch Capital LLC | $30 | 3 | 0.00% | 6q | HELD |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-10-28 | 13G/A | Integrated Core Strategies (US) LLCwith 3 co-filers | 0.2% |
| 2026-10-08 | 13G/A | Anders Hove INDIVIDUALwith 4 co-filers | 4.5% |
| 2026-09-25 | 13G/A | Anders Hove INDIVIDUALwith 4 co-filers | 5.7% |
| 2026-09-25 | 13G/A | Anders Hove INDIVIDUALwith 4 co-filers | 5.7% |
What the company announced
Form 8-K filings from the last 120 days, showing only the items worth a reader's attention. Earnings releases, exhibit attachments and general disclosures are filed constantly and are left out. Filed is when the SEC received it; event is the date the company says the thing happened.
| Filed | Event date | What | Source |
|---|---|---|---|
| 2026-09-18 | 2026-09-17 | Charter or bylaws amended | filing |
| 2026-09-11 | 2026-09-10 | Material agreement entered | filing |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 12 | $51.3K | 44,157 | 4 | 3 | 1 | 0.0% |
| Q2 2026 | 101 | $231.2M | 21,842,860 | 34 | 29 | 16 | 7.7% |
| Q1 2026 | 86 | $150.5M | 18,199,234 | 27 | 31 | 12 | 32.1% |
| Q4 2025 | 70 | $83.5M | 10,052,082 | 24 | 18 | 6 | 11.5% |
| Q3 2025 | 57 | $40.7M | 2,976,484 | 10 | 7 | 20 | 52.1% |
| Q2 2025 | 52 | $20.8M | 4,420,118 | 12 | 13 | 5 | 8.3% |
| Q1 2025 | 52 | $14.4M | 3,674,116 | 53 | 0 | 2 | 4.7% |
| Q4 2024 | 89 | $41.8M | 61,378,598 | 10 | 19 | 19 | 0.6% |
| Q3 2024 | 94 | $51.8M | 61,266,233 | 8 | 19 | 29 | 1.9% |
| Q2 2024 | 119 | $61.4M | 69,302,052 | 28 | 23 | 32 | 2.1% |
| Q1 2024 | 115 | $117.3M | 77,213,355 | 20 | 35 | 30 | 0.6% |
| Q4 2023 | 122 | $66.1M | 75,972,597 | 23 | 25 | 39 | 0.7% |
| Q3 2023 | 120 | $104.5M | 77,791,981 | 16 | 37 | 29 | 0.9% |
| Q2 2023 | 139 | $145.9M | 81,543,049 | 31 | 43 | 41 | 0.6% |
| Q1 2023 | 133 | $342.1M | 87,673,985 | 22 | 51 | 30 | 0.5% |
| Q4 2022 | 156 | $337.3M | 98,386,140 | 29 | 58 | 45 | 0.9% |
| Q3 2022 | 138 | $388.8M | 70,193,475 | 16 | 54 | 37 | 1.4% |
| Q2 2022 | 143 | $318.3M | 69,113,618 | 27 | 33 | 56 | 2.1% |
| Q1 2022 | 137 | $650.4M | 86,272,240 | 23 | 39 | 41 | 2.5% |
| Q4 2021 | 141 | $460.1M | 69,044,678 | 25 | 47 | 44 | 3.7% |
| Q3 2021 | 133 | $419.4M | 70,219,383 | 14 | 56 | 32 | 2.5% |
| Q2 2021 | 151 | $869.4M | 82,408,633 | 24 | 49 | 55 | 2.2% |
| Q1 2021 | 167 | $857.4M | 80,478,089 | 26 | 56 | 48 | 0.8% |
| Q4 2020 | 166 | $1.4B | 86,796,849 | 24 | 59 | 42 | 1.8% |
| Q3 2020 | 155 | $1.3B | 87,726,651 | 27 | 53 | 53 | 1.0% |
| Q2 2020 | 155 | $1.8B | 92,340,352 | 41 | 63 | 30 | 1.2% |
| Q1 2020 | 142 | $2.3B | 116,673,074 | 26 | 53 | 39 | 1.9% |
| Q4 2019 | 148 | $1.6B | 81,210,941 | 43 | 39 | 39 | 2.0% |
| Q3 2019 | 107 | $783.7M | 80,694,838 | 26 | 37 | 26 | 1.0% |
| Q2 2019 | 102 | $346.6M | 56,626,911 | 18 | 36 | 27 | 2.1% |
| Q1 2019 | 108 | $306.0M | 51,332,645 | 22 | 39 | 21 | 1.8% |
| Q4 2018 | 114 | $640.4M | 68,193,404 | 2 | 4 | 1 | 0.2% |
