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DaveManuel.com · Institutional Ownership · Who Owns It

KARYOPHARM THERAPEUTICS INC (KPTI)

Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.

101
Reporting holders
$231.2M
Reported value
96.3%
Of shares outstanding
5.9%
Calls
1.7%
Puts
+15
Holder change

Institutions report 21,842,860 shares against 22,681,460 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.

Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.

Holders

Download these holders as CSV

FilerValueShares Their book Held Change
RA CAPITAL MANAGEMENT, L.P.$18.7M1,917,3540.16%2qHELD
ADAGE CAPITAL PARTNERS GP, L.L.C.$14.9M1,521,3220.02%6q-15.8%-$2.8M
ACORN CAPITAL ADVISORS, LLC$14.8M1,518,1134.05%2q+427.4%+$12.0M
GOLDMAN SACHS GROUP INC$13.9M1,424,6580.00%2q+50.3%+$4.7M
BlackRock, Inc.$13.9M1,418,7990.00%6q+479.3%+$11.5M
Kalehua Capital Management LLC$13.4M1,371,2884.27%newNEW
VANGUARD CAPITAL MANAGEMENT LLC$9.4M958,9790.00%2q+29.6%+$2.1M
Catalio Capital Management, LP$9.2M940,8551.73%6q+4.8%+$421.5K
Avidity Partners Management LP$9.0M924,4871.45%6qHELD
T. Rowe Price Investment Management, Inc.$7.7M786,3090.01%6q-49.0%-$7.4M
TWO SIGMA INVESTMENTS, LP$6.8M695,2640.00%3q+359.7%+$5.3M
NEA Management Company, LLC$5.6M576,7800.35%newNEW
SUSQUEHANNA INTERNATIONAL GROUP, LLP$5.3M CALL+PUToptions only0.00%6qOPTIONS
GEODE CAPITAL MANAGEMENT, LLC$5.2M531,2310.00%6q+157.7%+$3.2M
Ghisallo Capital Management LLC$4.9M500,0000.10%newNEW
Soleus Capital Management, L.P.$4.3M440,0000.15%3qHELD
Caption Management, LLC$3.7M CALL+PUToptions only0.02%2qOPTIONS
UBS Group AG$3.5M353,5450.00%6q+82.2%+$1.6M
MILLENNIUM MANAGEMENT LLC$3.3M
incl. $351.7K options PUT
305,6760.00%2q-27.3%-$1.3M
STATE STREET CORP$3.2M325,9910.00%6q+303.7%+$2.4M
Affinity Asset Advisors, LLC$3.1M312,5000.14%5q-37.5%-$1.8M
Brevan Howard Capital Management LP$3.0M309,8170.02%2q+45.9%+$952.1K
Boxer Capital Management, LLC$3.0M302,5360.22%3qHELD
Davidson Kempner Capital Management LP$2.9M300,0000.03%3qHELD
ACADIAN ASSET MANAGEMENT LLC$2.9M298,9970.00%3q+20.1%+$488.0K
SILVERARC CAPITAL MANAGEMENT, LLC$2.9M297,4600.30%newNEW
Eversept Partners, LP$2.7M276,1740.14%2qHELD
Tetragon Partners GP Ltd$2.4M CALLoptions only0.39%2qOPTIONS
JPMORGAN CHASE & CO$2.2M
incl. $63.5K options CALL
207,6090.00%6q+43978.3%+$2.2M
MORGAN STANLEY$2.0M202,5060.00%6q+990.5%+$1.8M
Trexquant Investment LP$1.8M188,3680.01%3q-27.0%-$679.4K
BNP PARIBAS FINANCIAL MARKETS$1.8M188,0380.00%6q+223754.8%+$1.8M
DLD Asset Management, LP$1.8M CALL+PUToptions only0.12%newOPTIONS
BARCLAYS PLC$1.6M165,9040.00%6q+2134.7%+$1.5M
NORTHERN TRUST CORP$1.6M160,0060.00%6q+315.0%+$1.2M
VANGUARD FIDUCIARY TRUST CO$1.4M145,4010.00%2q+26.5%+$297.7K
J. Goldman & Co LP$1.3M
incl. $660.5K options PUT
67,5000.03%newNEW
VANGUARD PORTFOLIO MANAGEMENT LLC$1.3M134,8180.00%newNEW
SILVERBACK ASSET MANAGEMENT LLC$1.3M
incl. $977.0K options CALL
30,0000.14%6q-53.8%-$1.5M
MARSHALL WACE, LLP$1.3M128,4510.00%6qHELD
GROUP ONE TRADING LLC$1.2M CALL+PUToptions only0.00%6qOPTIONS
CITADEL ADVISORS LLC$1.2M
incl. $643.8K options CALL+PUT
52,0690.00%6qHELD
RENAISSANCE TECHNOLOGIES LLC$1.1M108,2140.00%6q+2.7%+$27.4K
C WorldWide Group Holding A/S$977.0K100,0000.02%6qHELD
Jump Financial, LLC$918.4K94,0000.01%3q-64.1%-$1.6M
Invesco Ltd.$882.3K90,3040.00%2q+439.5%+$718.7K
JANE STREET GROUP, LLC$842.9K
incl. $518.8K options CALL+PUT
33,1730.00%4q-68.7%-$1.8M
Connor, Clark & Lunn Investment Management Ltd.$746.4K76,3970.00%3q-3.4%-$26.2K
BRIDGEWAY CAPITAL MANAGEMENT, LLC$702.2K71,8730.01%5qHELD
Squarepoint Ops LLC$623.3K63,8010.00%newNEW
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$605.2K61,9430.00%2q+361.3%+$474.0K
ROYAL BANK OF CANADA$590.0K60,4300.00%6qHELD
Bank of New York Mellon Corp$559.4K57,2620.00%6q+402.3%+$448.1K
Susquehanna Portfolio Strategies, LLC$532.9K54,5450.01%2q+118.0%+$288.4K
XTX Topco Ltd$520.5K53,2720.01%5q-67.6%-$1.1M
BANK OF AMERICA CORP /DE/$487.8K49,9240.00%6q+156.4%+$297.5K
Birchview Capital, LP$419.6K42,9520.20%2q-48.8%-$400.6K
CITIGROUP INC$370.4K37,9170.00%6q+667.4%+$322.2K
Nuveen, LLC$370.0K37,8680.00%newNEW
Engineers Gate Manager LP$331.8K33,9660.00%2q-69.8%-$766.6K
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.$326.0K33,3330.00%newNEW
SIMPLEX TRADING, LLC$323.2K
incl. $87.9K options CALL+PUT
24,0860.00%newNEW
TORONTO DOMINION BANK$302.2K30,9300.00%newNEW
Baird Financial Group, Inc.$291.1K29,7910.00%5qHELD
PRICE T ROWE ASSOCIATES INC /MD/$266.0K27,2250.00%5q+150.1%+$159.6K
ExodusPoint Capital Management, LP$259.7K26,5820.00%newNEW
China Universal Asset Management Co., Ltd.$244.2K25,0000.01%2q-16.7%-$48.9K
RHUMBLINE ADVISERS$229.3K23,4670.00%newNEW
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC$227.3K23,2650.00%newNEW
Velan Capital Investment Management LP$195.4K20,0000.12%2q+33.3%+$48.9K
DEUTSCHE BANK AG\$189.8K19,4250.00%newNEW
WELLS FARGO & COMPANY/MN$165.1K16,9030.00%newNEW
SEI INVESTMENTS CO$147.4K15,0830.00%newNEW
HSBC HOLDINGS PLC$137.4K13,7500.00%2q+19.6%+$22.5K
Headlands Technologies LLC$118.3K12,1130.01%newNEW
MetLife Investment Management, LLC$117.4K12,0170.00%newNEW
Virtu Financial LLC$105.0K10,7280.00%newNEW
Y-Intercept (Hong Kong) Ltd$101.4K10,3750.00%newNEW
Quadrature Capital Ltd$100.6K10,2960.00%newNEW
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.$89.6K9,1710.00%newNEW
FMR LLC$87.3K8,9360.00%6q+1243.8%+$80.8K
Vanguard Global Advisers, LLC$80.2K8,2070.00%2qHELD
Police & Firemen's Retirement System of New Jersey$57.4K5,8740.00%newNEW
NEW YORK STATE COMMON RETIREMENT FUND$54.7K5,6000.00%newNEW
TD Waterhouse Canada Inc.$54.5K5,7070.00%6q+78.2%+$23.9K
Legal & General Group Plc$18.9K1,9350.00%newNEW
Ameritas Investment Partners, Inc.$17.7K1,8080.00%newNEW
Russell Investments Group, Ltd.$15.6K1,5920.00%newNEW
Tower Research Capital LLC (TRC)$12.3K1,2590.00%newNEW
OSAIC HOLDINGS, INC.$3.9K4020.00%6qHELD
Sterling Capital Management LLC$3.4K3520.00%newNEW
HARBOUR INVESTMENTS, INC.$2.8K2850.00%6qHELD
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM$2.7K2740.00%newNEW
Quent Capital, LLC$1.6K1660.00%4q-29.4%
MB, LEVIS & ASSOCIATES, LLC$9771000.00%6qHELD
SBI Securities Co., Ltd.$655670.00%6qHELD
Activest Wealth Management$645660.00%6qHELD
Allworth Financial LP$255260.00%6qHELD
Caitong International Asset Management Co., Ltd$137140.00%newNEW
West Branch Capital LLC$3030.00%6qHELD

Five percent filings

Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →

FiledFormFiler % of class
2026-10-2813G/AIntegrated Core Strategies (US) LLCwith 3 co-filers0.2%
2026-10-0813G/AAnders Hove INDIVIDUALwith 4 co-filers4.5%
2026-09-2513G/AAnders Hove INDIVIDUALwith 4 co-filers5.7%
2026-09-2513G/AAnders Hove INDIVIDUALwith 4 co-filers5.7%

What the company announced

Form 8-K filings from the last 120 days, showing only the items worth a reader's attention. Earnings releases, exhibit attachments and general disclosures are filed constantly and are left out. Filed is when the SEC received it; event is the date the company says the thing happened.

FiledEvent dateWhatSource
2026-09-182026-09-17Charter or bylaws amendedfiling
2026-09-112026-09-10Material agreement enteredfiling

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q3 202612$51.3K44,1574310.0%
Q2 2026101$231.2M21,842,8603429167.7%
Q1 202686$150.5M18,199,23427311232.1%
Q4 202570$83.5M10,052,0822418611.5%
Q3 202557$40.7M2,976,4841072052.1%
Q2 202552$20.8M4,420,118121358.3%
Q1 202552$14.4M3,674,11653024.7%
Q4 202489$41.8M61,378,5981019190.6%
Q3 202494$51.8M61,266,233819291.9%
Q2 2024119$61.4M69,302,0522823322.1%
Q1 2024115$117.3M77,213,3552035300.6%
Q4 2023122$66.1M75,972,5972325390.7%
Q3 2023120$104.5M77,791,9811637290.9%
Q2 2023139$145.9M81,543,0493143410.6%
Q1 2023133$342.1M87,673,9852251300.5%
Q4 2022156$337.3M98,386,1402958450.9%
Q3 2022138$388.8M70,193,4751654371.4%
Q2 2022143$318.3M69,113,6182733562.1%
Q1 2022137$650.4M86,272,2402339412.5%
Q4 2021141$460.1M69,044,6782547443.7%
Q3 2021133$419.4M70,219,3831456322.5%
Q2 2021151$869.4M82,408,6332449552.2%
Q1 2021167$857.4M80,478,0892656480.8%
Q4 2020166$1.4B86,796,8492459421.8%
Q3 2020155$1.3B87,726,6512753531.0%
Q2 2020155$1.8B92,340,3524163301.2%
Q1 2020142$2.3B116,673,0742653391.9%
Q4 2019148$1.6B81,210,9414339392.0%
Q3 2019107$783.7M80,694,8382637261.0%
Q2 2019102$346.6M56,626,9111836272.1%
Q1 2019108$306.0M51,332,6452239211.8%
Q4 2018114$640.4M68,193,4042410.2%