DaveManuel.com · Institutional Ownership · Who Owns It
PRAXIS PRECISION MEDICINES I (PRAX)
Institutional ownership reported to the SEC as of Q2 2026, across 24 quarters.
319
Reporting holders
$11.7B
Reported value
120.8%
Of shares outstanding
0.5%
Calls
2.7%
Puts
+18
Holder change
Institutions report 33,732,754 shares against 27,919,988 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| Jupiter Topco LLC | $1.1B | 3,421,374 | 0.47% | new | FIRST |
| FMR LLC | $775.7M | 2,316,907 | 0.03% | 11q | +7.2%+$52.2M |
| BlackRock, Inc. | $767.5M | 2,292,585 | 0.01% | 8q | -1.4%-$10.8M |
| PERCEPTIVE ADVISORS LLC | $681.6M | 2,035,986 | 10.23% | 10q | HELD |
| BAKER BROS. ADVISORS LP | $587.0M | 1,753,198 | 2.94% | 10q | HELD |
| Orbis Allan Gray Ltd | $512.2M | 1,529,788 | 1.76% | 3q | -38.1%-$315.6M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $447.0M | 1,335,185 | 0.02% | 2q | +76.4%+$193.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | $413.6M | 1,235,299 | 0.01% | 2q | +1.1%+$4.5M |
| STATE STREET CORP | $343.7M | 1,026,443 | 0.01% | 11q | +16.1%+$47.6M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $340.0M | 1,015,480 | 0.48% | 11q | +24.5%+$66.9M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $322.5M | 963,351 | 3.36% | 6q | HELD |
| Driehaus Capital Management LLC | $321.1M | 959,048 | 1.86% | 10q | +1.0%+$3.3M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $315.7M | 942,999 | 0.03% | 10q | +49.5%+$104.5M |
| MORGAN STANLEY | $285.9M | 854,112 | 0.02% | 11q | +2.5%+$6.9M |
| GEODE CAPITAL MANAGEMENT, LLC | $250.5M | 748,039 | 0.01% | 11q | +14.9%+$32.5M |
| Cormorant Asset Management, LP | $214.3M | 640,000 | 10.98% | 11q | -27.7%-$82.2M |
| GOLDMAN SACHS GROUP INC | $183.7M | 548,830 | 0.02% | 10q | -22.8%-$54.2M |
| BANK OF AMERICA CORP /DE/ | $183.1M | 546,930 | 0.01% | 11q | +2.3%+$4.1M |
| Invesco Ltd. | $180.0M | 537,548 | 0.01% | 10q | +775.5%+$159.4M |
| Hood River Capital Management LLC | $142.3M | 425,167 | 1.03% | 3q | +18.6%+$22.3M |
| NORGES BANK | $116.2M | 346,969 | 0.01% | 8q | +7869.0%+$114.7M |
| FRANKLIN RESOURCES INC | $109.5M | 327,124 | 0.02% | 10q | +18.5%+$17.1M |
| Pictet Asset Management Holding SA | $98.0M | 291,689 | 0.09% | 3q | +1.8%+$1.7M |
| Polar Capital Holdings Plc | $93.5M | 279,131 | 0.22% | new | NEW |
| Vivo Capital, LLC | $90.8M | 271,116 | 8.29% | 5q | -20.0%-$22.7M |
| Logos Global Management LP | $87.0M | 260,000 | 3.75% | 5q | -8.8%-$8.4M |
| NORTHERN TRUST CORP | $80.6M | 240,887 | 0.01% | 11q | +5.7%+$4.3M |
| AMERICAN CENTURY COMPANIES INC | $79.5M | 237,315 | 0.04% | 4q | +85.0%+$36.5M |
| ORBIMED ADVISORS LLC | $77.0M | 230,100 | 1.43% | 3q | +33.4%+$19.3M |
| Caption Management, LLC | $75.3M PUT | options only | 0.35% | 9q | OPTIONS |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $73.7M | 220,008 | 0.01% | 10q | +2.1%+$1.5M |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $73.3M | 218,898 | 0.24% | 2q | +32966.2%+$73.1M |
| Verition Fund Management LLC | $67.3M PUT | options only | 0.34% | new | OPTIONS |
| Woodline Partners LP | $67.0M | 200,013 | 0.21% | 7q | HELD |
| Nantahala Capital Management, LLC | $67.0M PUT | options only | 1.11% | new | OPTIONS |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $66.4M incl. $65.2M options CALL+PUT | 3,594 | 0.01% | 11q | -57.8%-$91.0M |
| BNP PARIBAS FINANCIAL MARKETS | $63.1M | 188,409 | 0.02% | 10q | +31.7%+$15.2M |
| VANGUARD FIDUCIARY TRUST CO | $63.0M | 188,161 | 0.01% | 2q | +10.7%+$6.1M |
| Affinity Asset Advisors, LLC | $61.9M | 185,000 | 2.80% | 3q | +8.8%+$5.0M |
| Soleus Capital Management, L.P. | $59.4M | 177,517 | 2.05% | 10q | -46.3%-$51.2M |
| Aberdeen Group plc | $55.7M | 166,399 | 0.08% | 3q | -3.5%-$2.0M |
| T. Rowe Price Investment Management, Inc. | $53.7M | 160,477 | 0.04% | 3q | -8.4%-$4.9M |
| Qube Research & Technologies Ltd | $51.0M | 152,475 | 0.05% | 4q | +18.9%+$8.1M |
| MARSHALL WACE, LLP | $45.9M | 137,008 | 0.04% | 4q | +203.5%+$30.8M |
| UBS Group AG | $43.9M | 131,046 | 0.01% | 11q | +20.8%+$7.6M |
| WELLINGTON MANAGEMENT GROUP LLP | $42.1M | 125,867 | 0.01% | 10q | -27.8%-$16.2M |
| VOYA INVESTMENT MANAGEMENT LLC | $40.9M | 122,227 | 0.04% | 3q | +334.4%+$31.5M |
| 683 Capital Management, LLC | $37.0M PUT | options only | 1.82% | 3q | OPTIONS |
| Nuveen, LLC | $36.2M | 108,032 | 0.01% | 6q | +50.0%+$12.0M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $36.0M | 107,409 | 0.01% | 3q | +1353.8%+$33.5M |
| Ikarian Capital, LLC | $31.4M incl. $7.0M options CALL+PUT | 72,842 | 3.38% | 6q | +1.8%+$543.3K |
| MetLife Investment Management, LLC | $30.3M | 90,543 | 0.14% | 9q | +11.9%+$3.2M |
| NEUBERGER BERMAN GROUP LLC | $30.0M | 89,468 | 0.02% | 3q | +244.6%+$21.3M |
| Velan Capital Investment Management LP | $29.7M | 88,781 | 18.10% | 11q | -11.9%-$4.0M |
| Bank of New York Mellon Corp | $28.6M | 85,376 | 0.00% | 9q | -1.9%-$559.4K |
| First Turn Management, LLC | $28.0M | 83,528 | 2.99% | 3q | +96.8%+$13.8M |
| ACUTA CAPITAL PARTNERS, LLC | $27.7M | 82,796 | 19.32% | 11q | -2.5%-$704.7K |
| Alyeska Investment Group, L.P. | $27.1M | 80,846 | 0.07% | 7q | +12.0%+$2.9M |
| ADAR1 Capital Management, LLC | $24.9M | 74,253 | 1.14% | 3q | +4850.2%+$24.4M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $24.8M | 74,207 | 0.23% | 2q | +39.1%+$7.0M |
| Ensign Peak Advisors, Inc | $24.4M | 72,952 | 0.04% | 3q | +6.7%+$1.5M |
| JANE STREET GROUP, LLC | $24.1M incl. $23.8M options CALL+PUT | 1,008 | 0.00% | 11q | HELD |
| ALLIANCEBERNSTEIN L.P. | $23.0M | 71,518 | 0.01% | 9q | +158.2%+$14.1M |
| 72 Investment Holdings, LLC | $22.1M | 65,933 | 44.18% | 11q | HELD |
| SILVERARC CAPITAL MANAGEMENT, LLC | $22.0M | 65,679 | 2.29% | 11q | -8.2%-$2.0M |
| AMERIPRISE FINANCIAL INC | $21.5M | 64,295 | 0.00% | 3q | +105.9%+$11.1M |
| DEUTSCHE BANK AG\ | $21.5M | 64,263 | 0.01% | 11q | +11.2%+$2.2M |
| RAYMOND JAMES FINANCIAL INC | $20.8M | 61,980 | 0.01% | 3q | +1065.0%+$19.0M |
| Candriam S.C.A. | $20.4M | 60,856 | 0.09% | 8q | -4.4%-$927.1K |
| AQR CAPITAL MANAGEMENT LLC | $19.6M | 58,446 | 0.01% | 5q | HELD |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $19.0M | 56,840 | 0.03% | new | NEW |
| Russell Investments Group, Ltd. | $17.1M | 51,033 | 0.01% | 5q | +120.8%+$9.3M |
| Squarepoint Ops LLC | $17.1M incl. $2.8M options CALL+PUT | 42,501 | 0.02% | 3q | +2014.5%+$16.3M |
| CITADEL ADVISORS LLC | $16.9M incl. $14.4M options CALL+PUT | 7,331 | 0.00% | 11q | HELD |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $16.1M | 48,118 | 0.02% | 3q | +1.4%+$229.7K |
| JPMORGAN CHASE & CO | $15.8M | 44,085 | 0.00% | 11q | -45.0%-$12.9M |
| Boxer Capital Management, LLC | $15.6M | 46,457 | 1.17% | 3q | HELD |
| Swiss National Bank | $15.4M | 46,100 | 0.01% | 9q | -1.3%-$200.9K |
| ArrowMark Colorado Holdings LLC | $15.4M | 46,030 | 0.64% | 3q | -60.9%-$24.0M |
| California Public Employees Retirement System | $15.2M | 45,370 | 0.01% | 2q | +7.6%+$1.1M |
| KVP Capital Advisors, LP | $14.4M | 42,900 | 10.54% | 3q | HELD |
| SEB Asset Management AB | $14.3M | 42,705 | 0.05% | new | NEW |
| SEI INVESTMENTS CO | $13.4M | 40,117 | 0.01% | 3q | +35.9%+$3.5M |
| Integral Health Asset Management, LLC | $13.4M | 40,000 | 0.53% | 3q | HELD |
| EVENTIDE ASSET MANAGEMENT, LLC | $13.0M | 38,684 | 0.17% | 3q | HELD |
| PFM Health Sciences, LP | $12.9M | 38,575 | 1.11% | 11q | +8.9%+$1.1M |
| STEMPOINT CAPITAL LP | $12.5M | 37,243 | 2.15% | 3q | -66.9%-$25.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $12.1M | 36,187 | 0.00% | 9q | -5.1%-$655.5K |
| Burkehill Global Management, LP | $11.7M | 35,000 | 0.42% | 3q | HELD |
| University of Wisconsin Foundation | $11.6M | 34,730 | 9.21% | 2q | +37.7%+$3.2M |
| B Group, Inc. | $11.1M | 33,237 | 5.22% | 6q | HELD |
| RHUMBLINE ADVISERS | $10.8M | 32,347 | 0.01% | 11q | -1.6%-$178.1K |
| DIMENSIONAL FUND ADVISORS LP | $10.6M | 31,574 | 0.00% | 4q | +1.3%+$138.3K |
| HighVista Strategies LLC | $10.1M | 30,210 | 2.31% | 8q | +14.8%+$1.3M |
| LORD, ABBETT & CO. LLC | $9.9M | 29,662 | 0.03% | 3q | HELD |
| Clearbridge Investments, LLC | $9.4M | 27,981 | 0.01% | new | NEW |
| WELLS FARGO & COMPANY/MN | $9.3M | 27,889 | 0.00% | 11q | +140.1%+$5.4M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $9.1M | 27,185 | 0.01% | 9q | -2.0%-$187.6K |
| Exome Asset Management LLC | $9.1M | 27,205 | 5.62% | 5q | -40.2%-$6.1M |
| TD Asset Management Inc | $9.1M | 27,162 | 0.01% | 10q | -22.7%-$2.7M |
Showing the largest 100 of 319 reported holders.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-06-24 | DeSimone Jill | Director | Sold | 11,600 | $3.6M ×12 |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 53 | $28.4M | 98,056 | 18 | 23 | 9 | 0.0% |
| Q2 2026 | 319 | $11.7B | 33,732,754 | 56 | 121 | 94 | 3.2% |
| Q1 2026 | 301 | $10.5B | 31,854,562 | 78 | 118 | 73 | 2.3% |
| Q4 2025 | 257 | $9.1B | 29,487,905 | 109 | 87 | 46 | 5.0% |
| Q3 2025 | 156 | $1.4B | 24,699,177 | 32 | 57 | 46 | 3.7% |
| Q2 2025 | 147 | $1.1B | 24,174,231 | 24 | 63 | 36 | 3.9% |
| Q1 2025 | 152 | $929.9M | 23,451,987 | 34 | 46 | 52 | 4.4% |
| Q4 2024 | 162 | $1.8B | 21,720,756 | 31 | 54 | 51 | 5.9% |
| Q3 2024 | 133 | $1.1B | 18,876,437 | 30 | 43 | 42 | 3.9% |
| Q2 2024 | 117 | $835.9M | 18,434,198 | 38 | 40 | 27 | 8.8% |
| Q1 2024 | 110 | $991.0M | 16,170,005 | 62 | 29 | 17 | 0.4% |
| Q4 2023 | 59 | $186.9M | 8,379,514 | 58 | 0 | 2 | 0.1% |
| Q3 2023 | 75 | $195.8M | 114,399,884 | 13 | 20 | 20 | 0.1% |
| Q2 2023 | 78 | $134.7M | 117,074,007 | 21 | 19 | 25 | 0.0% |
| Q1 2023 | 89 | $43.3M | 53,257,772 | 16 | 38 | 20 | 0.5% |
| Q4 2022 | 102 | $108.1M | 45,422,427 | 16 | 22 | 40 | 0.0% |
| Q3 2022 | 102 | $97.8M | 42,833,045 | 21 | 28 | 27 | 0.6% |
| Q2 2022 | 95 | $106.4M | 42,898,179 | 25 | 37 | 19 | 1.3% |
| Q1 2022 | 100 | $489.9M | 47,777,944 | 13 | 35 | 24 | 0.4% |
| Q4 2021 | 97 | $1.0B | 52,602,651 | 14 | 43 | 15 | 0.1% |
| Q3 2021 | 92 | $945.0M | 51,087,703 | 21 | 36 | 16 | 0.0% |
| Q2 2021 | 81 | $751.2M | 41,155,870 | 26 | 36 | 10 | 0.0% |
| Q1 2021 | 67 | $1.3B | 40,246,846 | 11 | 23 | 13 | 0.0% |
| Q4 2020 | 68 | $2.2B | 39,824,955 | 67 | 0 | 0 | 0.0% |