DaveManuel.com · Institutional Ownership · Who Owns It
PRELUDE THERAPEUTICS INC (PRLD)
Institutional ownership reported to the SEC as of Q2 2026, across 25 quarters.
78
Reporting holders
$266.3M
Reported value
62.2%
Of shares outstanding
0.4%
Calls
0.3%
Puts
+22
Holder change
Institutions report 49,599,407 shares against 79,803,485 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $73.2M | 13,724,571 | 1.36% | 24q | +25.8%+$15.0M |
| BAKER BROS. ADVISORS LP | $54.0M | 10,123,824 | 0.27% | 24q | HELD |
| RA CAPITAL MANAGEMENT, L.P. | $34.5M | 6,475,882 | 0.30% | new | NEW |
| Soleus Capital Management, L.P. | $18.0M | 3,378,378 | 0.62% | new | NEW |
| Kynam Capital Management, LP | $12.9M | 2,415,087 | 0.71% | 3q | +51.6%+$4.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | $10.7M | 2,009,445 | 0.00% | 2q | +63.3%+$4.2M |
| BlackRock, Inc. | $9.6M | 1,797,501 | 0.00% | 8q | +458.4%+$7.9M |
| SPHERA FUNDS MANAGEMENT LTD. | $5.4M | 1,019,832 | 0.71% | 3q | +82.7%+$2.5M |
| TWO SIGMA INVESTMENTS, LP | $5.3M | 993,369 | 0.00% | 19q | +7.6%+$371.7K |
| ADAR1 Capital Management, LLC | $4.8M | 900,900 | 0.22% | 2q | +489.5%+$4.0M |
| MILLENNIUM MANAGEMENT LLC | $4.5M | 844,993 | 0.00% | 8q | +120.8%+$2.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $4.5M | 841,862 | 0.00% | 23q | +178.3%+$2.9M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4.1M | 766,095 | 0.01% | new | NEW |
| ACADIAN ASSET MANAGEMENT LLC | $3.3M | 611,359 | 0.00% | 12q | +19.5%+$531.2K |
| MORGAN STANLEY | $2.7M | 503,860 | 0.00% | 24q | +56.4%+$968.5K |
| STATE STREET CORP | $2.3M | 428,787 | 0.00% | 23q | +210.2%+$1.5M |
| UBS Group AG | $1.7M | 318,797 | 0.00% | 15q | +394.2%+$1.4M |
| VANGUARD FIDUCIARY TRUST CO | $1.5M | 284,886 | 0.00% | 2q | +81.0%+$679.6K |
| RENAISSANCE TECHNOLOGIES LLC | $1.5M | 281,200 | 0.00% | 19q | +2.2%+$32.0K |
| NORTHERN TRUST CORP | $1.3M | 240,599 | 0.00% | 23q | +380.0%+$1.0M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1.0M | 193,920 | 0.00% | new | NEW |
| MARSHALL WACE, LLP | $1.0M | 190,692 | 0.00% | 3q | -46.9%-$896.6K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $931.2K CALL+PUT | options only | 0.00% | 3q | OPTIONS |
| Connor, Clark & Lunn Investment Management Ltd. | $669.5K | 125,606 | 0.00% | 3q | +15.1%+$88.1K |
| GOLDMAN SACHS GROUP INC | $644.0K | 120,834 | 0.00% | 22q | -48.9%-$616.3K |
| JANE STREET GROUP, LLC | $448.8K CALL+PUT | options only | 0.00% | 5q | OPTIONS |
| Hillsdale Investment Management Inc. | $433.9K | 81,400 | 0.01% | new | NEW |
| CITADEL ADVISORS LLC | $372.9K incl. $252.6K options CALL+PUT | 22,554 | 0.00% | 2q | -81.9%-$1.7M |
| Bank of New York Mellon Corp | $363.4K | 68,187 | 0.00% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $360.4K | 67,622 | 0.00% | new | NEW |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $343.8K | 64,500 | 0.01% | 17q | +20.6%+$58.6K |
| Squarepoint Ops LLC | $317.3K | 59,540 | 0.00% | new | NEW |
| SIMPLEX TRADING, LLC | $264.4K CALL+PUT | options only | 0.00% | 3q | OPTIONS |
| PANAGORA ASSET MANAGEMENT INC | $253.6K | 47,574 | 0.00% | new | NEW |
| Mariner, LLC | $241.2K | 45,261 | 0.00% | new | NEW |
| Nuveen, LLC | $197.3K | 37,023 | 0.00% | new | NEW |
| DIMENSIONAL FUND ADVISORS LP | $186.8K | 35,210 | 0.00% | 2q | HELD |
| Invesco Ltd. | $185.2K | 34,742 | 0.00% | new | NEW |
| Cerity Partners LLC | $175.2K | 32,875 | 0.00% | 8q | HELD |
| State of Wyoming | $175.2K | 32,862 | 0.02% | new | NEW |
| Graham Capital Management, L.P. | $158.7K | 29,770 | 0.00% | 2q | +162.5%+$98.2K |
| DEUTSCHE BANK AG\ | $148.3K | 27,824 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $135.0K | 25,325 | 0.00% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $127.3K | 23,875 | 0.00% | 23q | -57.8%-$174.0K |
| PRICE T ROWE ASSOCIATES INC /MD/ | $122.0K | 22,758 | 0.00% | new | NEW |
| RHUMBLINE ADVISERS | $117.6K | 22,074 | 0.00% | new | NEW |
| Vanguard Global Advisers, LLC | $86.4K | 16,210 | 0.00% | 2q | +249.7%+$61.7K |
| ExodusPoint Capital Management, LP | $82.5K | 15,475 | 0.00% | new | NEW |
| BARCLAYS PLC | $77.4K | 14,529 | 0.00% | 18q | +68.9%+$31.6K |
| NEW YORK STATE COMMON RETIREMENT FUND | $75.7K | 14,200 | 0.00% | new | NEW |
| HSBC HOLDINGS PLC | $74.4K | 13,652 | 0.00% | 12q | HELD |
| MANGROVE PARTNERS IM, LLC | $71.2K | 13,352 | 0.00% | new | NEW |
| Qube Research & Technologies Ltd | $69.9K | 13,110 | 0.00% | 3q | -20.1%-$17.6K |
| CITIGROUP INC | $69.5K | 13,033 | 0.00% | 23q | +260560.0%+$69.4K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $68.1K | 12,784 | 0.00% | new | NEW |
| GSA CAPITAL PARTNERS LLP | $68.0K | 12,672 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $66.7K | 13,538 | 0.00% | 23q | +21735.5%+$66.4K |
| Spark Investment Management LLC | $56.5K | 10,600 | 0.11% | new | NEW |
| Police & Firemen's Retirement System of New Jersey | $55.9K | 10,492 | 0.00% | new | NEW |
| GROUP ONE TRADING LLC | $41.6K incl. $20.8K options PUT | 3,907 | 0.00% | 8q | HELD |
| ALLIANCEBERNSTEIN L.P. | $36.0K | 10,530 | 0.00% | new | NEW |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $34.3K | 6,430 | 0.00% | new | NEW |
| FMR LLC | $30.0K | 5,629 | 0.00% | 24q | -6.3%-$2.0K |
| STRS OHIO | $29.3K | 5,500 | 0.00% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $21.9K | 4,104 | 0.00% | 7q | +4220.0%+$21.4K |
| Legal & General Group Plc | $14.4K | 2,699 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $14.0K | 2,658 | 0.00% | 23q | +14.0%+$1.7K |
| Ameritas Investment Partners, Inc. | $13.4K | 2,520 | 0.00% | new | NEW |
| Tower Research Capital LLC (TRC) | $12.7K | 2,377 | 0.00% | new | NEW |
| Russell Investments Group, Ltd. | $11.8K | 2,220 | 0.00% | new | NEW |
| NISA INVESTMENT ADVISORS, LLC | $8.7K | 1,634 | 0.00% | 7q | HELD |
| PNC Financial Services Group, Inc. | $6.2K | 1,171 | 0.00% | 9q | HELD |
| Quarry LP | $4.0K | 755 | 0.00% | new | NEW |
| Fortitude Family Office, LLC | $1.2K | 230 | 0.00% | 2q | HELD |
| Sterling Capital Management LLC | $517 | 97 | 0.00% | new | NEW |
| SBI Securities Co., Ltd. | $117 | 22 | 0.00% | 7q | -99.2%-$13.9K |
| Caitong International Asset Management Co., Ltd | $96 | 18 | 0.00% | new | NEW |
| Optiver Holding B.V. | $21 | 4 | 0.00% | 4q | -80.0% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 9 | $89.2K | 22,816 | 3 | 2 | 2 | 0.0% |
| Q2 2026 | 78 | $266.3M | 49,599,407 | 34 | 25 | 10 | 0.7% |
| Q1 2026 | 56 | $105.3M | 30,772,416 | 11 | 20 | 10 | 0.1% |
| Q4 2025 | 49 | $82.7M | 28,485,924 | 12 | 14 | 14 | 0.1% |
| Q3 2025 | 46 | $39.1M | 27,165,731 | 4 | 8 | 22 | 0.0% |
| Q2 2025 | 50 | $22.0M | 27,190,823 | 7 | 13 | 22 | 0.0% |
| Q1 2025 | 57 | $23.3M | 30,346,417 | 4 | 18 | 22 | 0.1% |
| Q4 2024 | 61 | $41.0M | 32,169,665 | 6 | 24 | 12 | 0.0% |
| Q3 2024 | 69 | $74.0M | 35,760,648 | 16 | 19 | 19 | 0.0% |
| Q2 2024 | 61 | $129.2M | 33,923,355 | 9 | 13 | 21 | 0.0% |
| Q1 2024 | 57 | $165.0M | 34,810,792 | 6 | 16 | 20 | 0.0% |
| Q4 2023 | 56 | $149.6M | 35,033,399 | 7 | 27 | 12 | 0.0% |
| Q3 2023 | 57 | $113.1M | 36,614,209 | 6 | 23 | 16 | 0.0% |
| Q2 2023 | 53 | $176.2M | 38,547,583 | 15 | 23 | 9 | 0.0% |
| Q1 2023 | 55 | $205.5M | 36,057,039 | 8 | 17 | 12 | 0.0% |
| Q4 2022 | 60 | $188.3M | 31,178,723 | 13 | 10 | 24 | 0.0% |
| Q3 2022 | 48 | $195.8M | 29,384,837 | 5 | 15 | 17 | 0.8% |
| Q2 2022 | 56 | $160.2M | 30,282,257 | 10 | 15 | 20 | 1.3% |
| Q1 2022 | 64 | $220.0M | 31,652,700 | 8 | 17 | 26 | 0.7% |
| Q4 2021 | 76 | $419.3M | 33,667,492 | 29 | 26 | 13 | 0.0% |
| Q3 2021 | 59 | $1.2B | 37,670,717 | 9 | 24 | 13 | 0.0% |
| Q2 2021 | 55 | $1.0B | 36,357,485 | 8 | 23 | 11 | 0.0% |
| Q1 2021 | 58 | $1.5B | 34,772,656 | 16 | 25 | 8 | 0.0% |
| Q4 2020 | 49 | $2.6B | 37,007,464 | 30 | 5 | 6 | 0.0% |
| Q3 2020 | 37 | $977.9M | 32,595,598 | 37 | 0 | 0 | 0.0% |