DaveManuel.com · Institutional Ownership · Who Owns It
PROTAGONIST THERAPEUTICS INC (PTGX)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
347
Reporting holders
$9.4B
Reported value
117.1%
Of shares outstanding
0.5%
Calls
0.3%
Puts
+21
Holder change
Institutions report 75,793,386 shares against 64,708,285 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| BlackRock, Inc. | $1.3B | 10,307,837 | 0.02% | 8q | +5.4%+$64.8M |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $778.2M | 6,348,906 | 3.59% | 31q | HELD |
| RTW INVESTMENTS, LP | $620.4M | 5,061,175 | 5.30% | 28q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $444.9M | 3,629,298 | 0.02% | 2q | +4.3%+$18.2M |
| WELLINGTON MANAGEMENT GROUP LLP | $418.8M | 3,416,781 | 0.07% | 8q | -5.1%-$22.4M |
| UBS Group AG | $416.7M | 3,399,221 | 0.05% | 31q | -34.4%-$218.0M |
| STATE STREET CORP | $407.2M | 3,321,554 | 0.01% | 31q | +6.6%+$25.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | $349.8M | 2,853,394 | 0.01% | 2q | +1.7%+$5.8M |
| JOHNSON & JOHNSON | $300.2M | 2,449,183 | 37.59% | 20q | HELD |
| Invesco Ltd. | $286.9M | 2,340,667 | 0.02% | 22q | +8.1%+$21.6M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $263.5M | 2,149,662 | 0.03% | 14q | +29.1%+$59.3M |
| Jupiter Topco LLC | $261.0M | 2,129,780 | 0.11% | new | FIRST |
| GEODE CAPITAL MANAGEMENT, LLC | $213.5M | 1,741,209 | 0.01% | 31q | +4.3%+$8.8M |
| Woodline Partners LP | $173.3M | 1,414,173 | 0.54% | 10q | HELD |
| BANK OF AMERICA CORP /DE/ | $162.4M | 1,324,498 | 0.01% | 31q | +2.2%+$3.6M |
| JENNISON ASSOCIATES LLC | $141.2M | 1,151,681 | 0.08% | 3q | +7.4%+$9.8M |
| PERCEPTIVE ADVISORS LLC | $120.4M | 981,879 | 1.81% | 14q | -20.2%-$30.5M |
| ADAR1 Capital Management, LLC | $117.8M | 960,863 | 5.39% | 11q | -3.3%-$4.1M |
| MORGAN STANLEY | $111.1M | 905,992 | 0.01% | 35q | -11.0%-$13.8M |
| Alyeska Investment Group, L.P. | $109.0M | 889,298 | 0.28% | 3q | +49.9%+$36.3M |
| Hood River Capital Management LLC | $108.2M | 882,738 | 0.78% | 2q | +6.4%+$6.6M |
| GOLDMAN SACHS GROUP INC | $99.6M | 812,852 | 0.01% | 31q | +4.4%+$4.2M |
| Driehaus Capital Management LLC | $89.6M | 731,053 | 0.52% | 11q | +1.4%+$1.2M |
| Clearbridge Investments, LLC | $88.9M | 725,335 | 0.07% | 3q | +16.6%+$12.7M |
| FMR LLC | $82.4M | 672,186 | 0.00% | 31q | +1.5%+$1.2M |
| NORTHERN TRUST CORP | $81.7M | 666,105 | 0.01% | 31q | +13.3%+$9.6M |
| AMERICAN CENTURY COMPANIES INC | $73.4M | 598,600 | 0.03% | 11q | +11.4%+$7.5M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $71.6M | 583,774 | 0.01% | 29q | +5.6%+$3.8M |
| VOYA INVESTMENT MANAGEMENT LLC | $70.1M | 571,618 | 0.06% | 24q | +25.8%+$14.4M |
| Pictet Asset Management Holding SA | $69.6M | 567,990 | 0.07% | 9q | -2.3%-$1.6M |
| FRANKLIN RESOURCES INC | $63.7M | 520,032 | 0.01% | 10q | +277.2%+$46.8M |
| VANGUARD FIDUCIARY TRUST CO | $53.7M | 437,747 | 0.01% | 2q | +6.1%+$3.1M |
| LORD, ABBETT & CO. LLC | $48.9M | 398,994 | 0.14% | 2q | +144.1%+$28.9M |
| PRINCIPAL FINANCIAL GROUP INC | $47.2M | 385,262 | 0.02% | 16q | +4.7%+$2.1M |
| Bank of New York Mellon Corp | $43.9M | 358,300 | 0.01% | 31q | +4.9%+$2.1M |
| Caption Management, LLC | $43.7M incl. $38.2M options CALL+PUT | 45,000 | 0.20% | 8q | HELD |
| NEUBERGER BERMAN GROUP LLC | $37.1M | 302,427 | 0.02% | 5q | +113.8%+$19.7M |
| BNP PARIBAS FINANCIAL MARKETS | $37.0M | 301,472 | 0.01% | 31q | +55.0%+$13.1M |
| 683 Capital Management, LLC | $35.5M | 290,000 | 1.75% | 15q | -18.3%-$8.0M |
| Nuveen, LLC | $34.8M | 284,085 | 0.01% | 6q | +122.1%+$19.1M |
| Stephens Investment Management Group LLC | $34.5M | 281,832 | 0.37% | new | NEW |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $31.9M | 259,972 | 0.03% | 8q | -15.1%-$5.6M |
| Eagle Health Investments LP | $30.4M | 248,322 | 5.05% | 3q | +38.5%+$8.5M |
| NEXTBio Capital Management LP | $26.9M | 219,333 | 12.37% | 3q | -4.5%-$1.3M |
| SEGALL BRYANT & HAMILL, LLC | $26.3M | 214,724 | 0.31% | 5q | +0.9%+$246.4K |
| SEB Asset Management AB | $25.7M | 209,963 | 0.10% | 2q | -9.7%-$2.8M |
| Duquesne Family Office LLC | $25.6M | 208,900 | 0.49% | 4q | +30.8%+$6.0M |
| Public Sector Pension Investment Board | $25.5M | 207,688 | 0.07% | 8q | -1.2%-$317.7K |
| CITIGROUP INC | $24.4M | 198,668 | 0.01% | 30q | +25.2%+$4.9M |
| ORBIMED ADVISORS LLC | $23.5M incl. $18.4M options CALL | 42,100 | 0.44% | 3q | HELD |
| JPMORGAN CHASE & CO | $22.6M | 183,098 | 0.00% | 31q | +5.8%+$1.2M |
| DIMENSIONAL FUND ADVISORS LP | $21.8M | 178,152 | 0.00% | 31q | -64.9%-$40.4M |
| Affinity Asset Advisors, LLC | $21.1M | 172,125 | 0.95% | 7q | HELD |
| Fisher Asset Management, LLC | $20.9M | 170,524 | 0.01% | 3q | -2.0%-$422.5K |
| Boxer Capital Management, LLC | $20.8M | 170,000 | 1.57% | 5q | HELD |
| RAYMOND JAMES FINANCIAL INC | $20.6M | 168,270 | 0.01% | 7q | -5.1%-$1.1M |
| NAN FUNG TRINITY (HK) LTD | $19.7M | 160,670 | 1.94% | 5q | HELD |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $19.4M incl. $12.4M options CALL+PUT | 57,062 | 0.00% | 24q | -65.9%-$37.5M |
| AMERIPRISE FINANCIAL INC | $17.6M | 143,810 | 0.00% | 8q | -1.3%-$230.5K |
| DEUTSCHE BANK AG\ | $17.4M | 141,838 | 0.01% | 34q | +13.1%+$2.0M |
| RHUMBLINE ADVISERS | $17.3M | 141,279 | 0.01% | 29q | -10.2%-$2.0M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $17.3M | 141,081 | 0.03% | new | NEW |
| TD Asset Management Inc | $16.5M | 134,950 | 0.01% | 14q | -26.5%-$6.0M |
| KENNEDY CAPITAL MANAGEMENT LLC | $16.4M | 134,019 | 0.29% | 22q | -2.2%-$377.5K |
| Legal & General Group Plc | $16.2M | 132,351 | 0.00% | 29q | -2.2%-$369.7K |
| Russell Investments Group, Ltd. | $14.1M | 115,425 | 0.01% | 10q | +185.9%+$9.2M |
| MARSHALL WACE, LLP | $13.4M | 109,017 | 0.01% | 4q | -82.6%-$63.6M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $13.3M | 108,555 | 0.01% | 29q | -15.1%-$2.4M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $13.1M | 107,094 | 0.00% | 14q | HELD |
| Catalio Capital Management, LP | $13.1M | 106,799 | 2.46% | new | NEW |
| Swiss National Bank | $12.6M | 102,400 | 0.01% | 23q | +3.5%+$429.0K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $12.5M | 102,002 | 0.02% | 6q | -3.3%-$430.5K |
| Opaleye Management Inc. | $12.3M | 100,000 | 1.11% | 11q | HELD |
| ASSETMARK, INC | $12.1M | 98,687 | 0.02% | 8q | +112.5%+$6.4M |
| SEI INVESTMENTS CO | $11.4M | 92,749 | 0.01% | 22q | +11.5%+$1.2M |
| ALGERT GLOBAL LLC | $10.8M | 87,698 | 0.13% | 3q | +11.8%+$1.1M |
| PRUDENTIAL FINANCIAL INC | $10.4M | 85,180 | 0.01% | 8q | -10.6%-$1.2M |
| VICTORY CAPITAL MANAGEMENT INC | $10.3M | 83,883 | 0.01% | 10q | HELD |
| AXIOM INVESTORS LLC /DE | $10.0M | 81,683 | 0.09% | 6q | -4.4%-$464.8K |
| WELLS FARGO & COMPANY/MN | $8.8M | 71,944 | 0.00% | 31q | +139.2%+$5.1M |
| ALLIANCEBERNSTEIN L.P. | $8.4M | 79,563 | 0.00% | 28q | +7.8%+$608.5K |
| NORDEA INVESTMENT MANAGEMENT AB | $7.9M | 64,964 | 0.01% | 2q | +25.4%+$1.6M |
| Knott David M Jr | $7.7M | 63,000 | 4.08% | 12q | HELD |
| Atika Capital Management LLC | $7.6M | 62,100 | 0.50% | 4q | HELD |
| Moody Aldrich Partners LLC | $7.3M | 59,601 | 1.31% | 13q | +10.6%+$699.7K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $7.2M | 58,961 | 0.01% | 29q | HELD |
| Eversept Partners, LP | $7.2M | 58,504 | 0.37% | new | NEW |
| GREAT LAKES ADVISORS, LLC | $7.0M | 56,904 | 0.05% | 14q | -19.9%-$1.7M |
| Creative Planning | $6.9M | 56,185 | 0.00% | 8q | +17.1%+$1.0M |
| Bellevue Group AG | $6.8M | 55,682 | 0.14% | 12q | +285.4%+$5.1M |
| FIRST TRUST ADVISORS LP | $6.7M | 54,865 | 0.00% | 10q | -37.6%-$4.0M |
| KVP Capital Advisors, LP | $6.5M | 53,000 | 4.77% | 3q | HELD |
| BESSEMER GROUP INC | $6.4M | 52,074 | 0.01% | 8q | -3.9%-$257.9K |
| VANGUARD ASSET MANAGEMENT, Ltd | $6.3M | 51,639 | 0.00% | 2q | +11.3%+$643.9K |
| CASTLEARK MANAGEMENT LLC | $6.2M | 50,570 | 0.17% | new | NEW |
| Granahan Investment Management, LLC | $6.1M | 49,809 | 0.22% | 2q | +81.8%+$2.7M |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $6.1M | 49,550 | 0.01% | 8q | +4.5%+$260.6K |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $6.0M | 48,894 | 0.00% | 9q | HELD |
| CANADA LIFE ASSURANCE Co | $5.9M | 48,045 | 0.01% | 23q | +1.3%+$74.1K |
| CITADEL ADVISORS LLC | $5.6M CALL+PUT | options only | 0.00% | 23q | OPTIONS |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-10-27 | 13G/A | BlackRock, Inc. | 15.2% |
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-08-10 | PATEL DINESH V PH D | President and CEO | Sold | 65,761 | $9.8M |
| 2026-09-09 | PATEL DINESH V PH D | President and CEO | Sold | 63,548 | $9.3M |
| 2026-09-30 | Ali Asif | Chief Financial Officer | Sold | 58,629 | $8.3M ×2 |
| 2026-09-08 | PATEL DINESH V PH D | President and CEO | Sold | 54,174 | $7.9M |
| 2026-05-12 | PATEL DINESH V PH D | President and CEO | Sold | 75,000 | $7.5M |
| 2026-05-12 | PATEL DINESH V PH D | President and CEO | Sold | 75,000 | $7.5M |
| 2026-08-11 | PATEL DINESH V PH D | President and CEO | Sold | 34,239 | $5.1M |
| 2026-05-08 | Giraudo Bryan | Director | Sold | 11,130 | $1.1M ×2 |
| 2026-06-23 | Waddill William D. | Director | Sold | 9,000 | $1.1M |
| 2026-09-10 | PATEL DINESH V PH D | President and CEO | Sold | 7,278 | $1.0M |
| 2026-06-10 | Waddill William D. | Director | Sold | 9,000 | $969.1K |
| 2026-05-29 | Waddill William D. | Director | Sold | 9,000 | $896.8K |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 84 | $414.4M | 2,941,040 | 21 | 24 | 13 | 0.0% |
| Q2 2026 | 347 | $9.4B | 75,793,386 | 59 | 132 | 81 | 0.9% |
| Q1 2026 | 326 | $8.4B | 78,833,733 | 52 | 103 | 100 | 0.6% |
| Q4 2025 | 323 | $6.3B | 71,028,815 | 71 | 96 | 101 | 1.4% |
| Q3 2025 | 278 | $4.7B | 70,936,921 | 39 | 81 | 106 | 0.3% |
| Q2 2025 | 278 | $4.0B | 71,042,753 | 52 | 117 | 75 | 1.0% |
| Q1 2025 | 280 | $3.2B | 65,441,797 | 70 | 83 | 90 | 2.6% |
| Q4 2024 | 242 | $2.5B | 63,787,738 | 40 | 86 | 72 | 0.7% |
| Q3 2024 | 244 | $2.8B | 62,314,615 | 80 | 73 | 61 | 0.3% |
| Q2 2024 | 191 | $2.1B | 59,493,127 | 30 | 60 | 65 | 0.4% |
| Q1 2024 | 184 | $1.9B | 64,020,765 | 50 | 57 | 53 | 0.4% |
| Q4 2023 | 156 | $1.4B | 59,115,745 | 25 | 39 | 57 | 1.2% |
| Q3 2023 | 144 | $959.9M | 56,750,373 | 17 | 63 | 39 | 1.4% |
| Q2 2023 | 170 | $1.6B | 56,732,434 | 44 | 58 | 49 | 4.4% |
| Q1 2023 | 142 | $1.3B | 53,289,111 | 40 | 44 | 43 | 4.3% |
| Q4 2022 | 138 | $546.3M | 48,884,879 | 21 | 48 | 44 | 2.4% |
| Q3 2022 | 125 | $429.3M | 49,991,079 | 27 | 35 | 38 | 1.8% |
| Q2 2022 | 128 | $469.9M | 56,408,611 | 27 | 42 | 38 | 5.0% |
| Q1 2022 | 139 | $1.3B | 53,905,527 | 19 | 51 | 45 | 5.0% |
| Q4 2021 | 150 | $2.2B | 61,980,724 | 32 | 56 | 33 | 3.8% |
| Q3 2021 | 130 | $1.1B | 58,087,252 | 28 | 56 | 33 | 3.8% |
| Q2 2021 | 136 | $2.8B | 62,381,914 | 27 | 56 | 34 | 0.1% |
| Q1 2021 | 126 | $1.4B | 53,566,135 | 24 | 40 | 40 | 0.1% |
| Q4 2020 | 125 | $1.1B | 52,651,706 | 39 | 47 | 20 | 0.2% |
| Q3 2020 | 91 | $909.1M | 46,538,898 | 22 | 27 | 31 | 0.0% |
| Q2 2020 | 83 | $935.5M | 52,969,163 | 25 | 41 | 13 | 0.0% |
| Q1 2020 | 75 | $165.0M | 23,371,160 | 6 | 23 | 27 | 0.0% |
| Q4 2019 | 79 | $165.4M | 23,464,419 | 16 | 33 | 14 | 0.0% |
| Q3 2019 | 72 | $306.8M | 25,536,906 | 16 | 28 | 18 | 0.0% |
| Q2 2019 | 65 | $208.5M | 17,221,245 | 15 | 29 | 16 | 0.0% |
| Q1 2019 | 63 | $189.3M | 15,062,267 | 11 | 23 | 22 | 0.0% |
| Q4 2018 | 64 | $94.0M | 13,974,692 | 2 | 0 | 3 | 0.0% |