DaveManuel.com · Institutional Ownership · Who Owns It
ULTRAGENYX PHARMACEUTICAL IN (RARE)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
319
Reporting holders
$3.7B
Reported value
108.4%
Of shares outstanding
1.6%
Calls
1.9%
Puts
+20
Holder change
Institutions report 106,904,688 shares against 98,588,873 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| BlackRock, Inc. | $355.7M | 10,654,276 | 0.01% | 8q | +46.0%+$112.0M |
| RTW INVESTMENTS, LP | $260.3M | 7,796,895 | 2.22% | 19q | +113.7%+$138.5M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $226.7M | 6,790,135 | 0.01% | 2q | +26.1%+$46.9M |
| AQR CAPITAL MANAGEMENT LLC | $214.1M | 6,560,809 | 0.07% | 11q | +43.3%+$64.7M |
| STATE STREET CORP | $205.6M | 6,158,766 | 0.01% | 31q | +22.6%+$38.0M |
| VANGUARD CAPITAL MANAGEMENT LLC | $143.5M | 4,296,491 | 0.00% | 2q | +2.5%+$3.6M |
| TWO SIGMA INVESTMENTS, LP | $120.9M | 3,621,200 | 0.09% | 18q | +64.2%+$47.3M |
| SANDS CAPITAL MANAGEMENT, LLC | $105.5M | 3,158,368 | 0.39% | 13q | -1.7%-$1.9M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $98.2M | 2,939,719 | 0.35% | 5q | +105.4%+$50.4M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $95.1M | 2,847,936 | 0.89% | 5q | +30.0%+$21.9M |
| GEODE CAPITAL MANAGEMENT, LLC | $86.1M | 2,578,828 | 0.00% | 31q | +39.4%+$24.4M |
| Sofinnova Investments, Inc. | $74.0M incl. $16.7M options CALL | 1,717,505 | 3.83% | 3q | -45.4%-$61.6M |
| Bellevue Group AG | $66.2M | 1,982,775 | 1.39% | 3q | -16.7%-$13.3M |
| D. E. Shaw & Co., Inc. | $57.8M | 1,730,193 | 0.03% | 9q | +37.2%+$15.7M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $52.8M | 1,580,000 | 0.07% | 23q | +229.2%+$36.7M |
| GW&K Investment Management, LLC | $49.5M | 1,481,178 | 0.39% | 14q | -8.3%-$4.5M |
| MPM BIOIMPACT LLC | $47.4M | 1,418,215 | 2.89% | new | NEW |
| PRICE T ROWE ASSOCIATES INC /MD/ | $45.3M | 1,356,501 | 0.00% | 31q | +68.7%+$18.4M |
| MORGAN STANLEY | $44.2M | 1,324,805 | 0.00% | 35q | -11.7%-$5.9M |
| Caption Management, LLC | $42.1M incl. $37.8M options CALL+PUT | 130,000 | 0.20% | 8q | +18.2%+$6.5M |
| WELLINGTON MANAGEMENT GROUP LLP | $41.8M | 1,250,464 | 0.01% | 31q | -52.6%-$46.4M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $41.5M | 1,241,556 | 0.18% | 4q | -13.0%-$6.2M |
| BANK OF AMERICA CORP /DE/ | $38.3M | 1,148,454 | 0.00% | 31q | +9.7%+$3.4M |
| Candriam S.C.A. | $33.4M | 1,001,841 | 0.15% | 23q | -8.6%-$3.1M |
| Rock Springs Capital Management LP | $32.3M | 967,855 | 1.58% | 31q | -20.6%-$8.4M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $32.3M incl. $26.2M options CALL+PUT | 180,871 | 0.00% | 31q | -65.5%-$61.3M |
| Jefferies Financial Group Inc. | $31.0M | 929,626 | 0.20% | 3q | +5902.2%+$30.5M |
| NORTHERN TRUST CORP | $30.7M | 920,314 | 0.00% | 31q | +71.8%+$12.8M |
| Eagle Health Investments LP | $29.5M | 884,121 | 4.89% | 2q | HELD |
| Qube Research & Technologies Ltd | $29.5M | 882,219 | 0.03% | 2q | -3.6%-$1.1M |
| Russell Investments Group, Ltd. | $26.2M | 784,099 | 0.02% | 16q | +94.6%+$12.7M |
| MILLENNIUM MANAGEMENT LLC | $25.4M | 760,825 | 0.01% | 26q | -57.1%-$33.8M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $25.4M | 760,039 | 0.00% | 31q | +36.1%+$6.7M |
| Nuveen, LLC | $23.2M | 693,959 | 0.01% | 6q | +4.8%+$1.1M |
| Pictet Asset Management Holding SA | $23.2M | 753,695 | 0.02% | 12q | +24.9%+$4.6M |
| VANGUARD FIDUCIARY TRUST CO | $22.4M | 671,411 | 0.00% | 2q | +10.4%+$2.1M |
| UBS Group AG | $22.0M | 657,699 | 0.00% | 31q | -21.0%-$5.8M |
| GOLDMAN SACHS GROUP INC | $21.2M incl. $2.0M options CALL | 575,338 | 0.00% | 31q | +62.9%+$8.2M |
| GREAT POINT PARTNERS LLC | $20.0M PUT | options only | 3.79% | new | OPTIONS |
| Palo Alto Investors LP | $19.9M | 596,495 | 2.75% | 5q | HELD |
| SPHERA FUNDS MANAGEMENT LTD. | $19.6M | 588,494 | 2.56% | 16q | -27.3%-$7.4M |
| Legal & General Group Plc | $19.6M | 586,520 | 0.00% | 31q | -0.6%-$126.0K |
| PANAGORA ASSET MANAGEMENT INC | $19.6M | 586,230 | 0.06% | new | NEW |
| FMR LLC | $19.3M | 576,849 | 0.00% | 31q | +100.8%+$9.7M |
| Trexquant Investment LP | $18.6M | 556,385 | 0.11% | 18q | +42.9%+$5.6M |
| BNP PARIBAS FINANCIAL MARKETS | $16.6M | 498,167 | 0.01% | 31q | +1.5%+$246.6K |
| Bank of New York Mellon Corp | $15.7M | 470,697 | 0.00% | 31q | +38.0%+$4.3M |
| JPMORGAN CHASE & CO | $15.3M | 493,126 | 0.00% | 31q | +100.5%+$7.7M |
| TORONTO DOMINION BANK | $13.9M | 415,000 | 0.02% | 3q | +256072.8%+$13.9M |
| RENAISSANCE TECHNOLOGIES LLC | $13.8M | 413,700 | 0.02% | 8q | -26.3%-$4.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $13.7M | 409,255 | 0.01% | 11q | -2.1%-$297.0K |
| Krensavage Asset Management, LLC | $13.1M | 390,879 | 4.96% | 3q | HELD |
| ALGERT GLOBAL LLC | $13.0M | 389,964 | 0.15% | 14q | -9.0%-$1.3M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $12.7M | 381,420 | 0.01% | 18q | -15.5%-$2.3M |
| SummitTX Capital, L.P. | $12.5M | 374,270 | 0.32% | 2q | +7.6%+$885.2K |
| CITADEL ADVISORS LLC | $11.6M incl. $4.6M options CALL+PUT | 210,531 | 0.00% | 31q | -90.0%-$105.0M |
| Walleye Capital LLC | $11.6M incl. $380.6K options PUT | 334,854 | 0.04% | 16q | +179.7%+$7.4M |
| Privium Fund Management B.V. | $11.3M | 338,800 | 2.08% | 19q | -7.1%-$868.2K |
| Squarepoint Ops LLC | $11.3M | 338,368 | 0.01% | 7q | -23.9%-$3.5M |
| Catalio Capital Management, LP | $10.6M | 316,252 | 1.98% | 5q | -62.8%-$17.8M |
| FRANKLIN RESOURCES INC | $10.5M | 315,766 | 0.00% | 28q | +1.0%+$104.8K |
| CITIGROUP INC | $10.0M | 298,785 | 0.00% | 31q | -5.3%-$556.1K |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $9.9M | 297,819 | 0.01% | 3q | +63.8%+$3.9M |
| Ensign Peak Advisors, Inc | $9.7M | 290,818 | 0.02% | 19q | +4227.0%+$9.5M |
| GordonMD Global Investments LP | $9.7M | 289,101 | 4.67% | 3q | HELD |
| Jump Financial, LLC | $9.6M | 286,952 | 0.08% | 9q | -43.1%-$7.3M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $9.1M | 272,882 | 0.00% | 10q | +4.8%+$417.3K |
| Invesco Ltd. | $8.4M | 250,533 | 0.00% | 31q | -13.5%-$1.3M |
| Quantinno Capital Management LP | $8.4M | 250,466 | 0.01% | 4q | +33.6%+$2.1M |
| Assenagon Asset Management S.A. | $8.1M | 241,728 | 0.01% | 17q | -89.3%-$67.3M |
| KENNEDY CAPITAL MANAGEMENT LLC | $7.2M | 215,997 | 0.13% | 2q | -1.5%-$110.0K |
| WORLDQUANT MILLENNIUM ADVISORS LLC | $7.2M | 214,374 | 0.02% | 3q | +42.4%+$2.1M |
| SEI INVESTMENTS CO | $7.1M | 211,833 | 0.01% | 19q | +130.0%+$4.0M |
| Ishara Investments LP | $6.8M | 205,000 | 5.03% | 3q | +17.6%+$1.0M |
| Man Group plc | $6.5M | 195,110 | 0.01% | 18q | -8.6%-$609.1K |
| FIFTH THIRD BANCORP | $6.5M | 193,236 | 0.01% | 2q | +75.2%+$2.8M |
| Connor, Clark & Lunn Investment Management Ltd. | $6.4M | 191,578 | 0.01% | 17q | -61.8%-$10.3M |
| Stonepine Capital Management, LLC | $6.3M incl. $5.5M options CALL | 25,000 | 3.57% | new | NEW |
| Blue Owl Capital Holdings LP | $6.1M | 182,638 | 0.92% | 11q | -39.7%-$4.0M |
| Woodline Partners LP | $5.7M | 171,805 | 0.02% | 13q | HELD |
| Atom Investors LP | $5.7M | 171,771 | 0.51% | 2q | +83.5%+$2.6M |
| Swiss National Bank | $5.6M | 167,652 | 0.00% | 31q | -2.0%-$113.5K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5.6M | 167,226 | 0.00% | 31q | -25.0%-$1.9M |
| Ikarian Capital, LLC | $5.5M | 165,617 | 0.60% | 8q | -65.7%-$10.6M |
| DEUTSCHE BANK AG\ | $5.5M | 164,813 | 0.00% | 34q | +129.3%+$3.1M |
| MARSHALL WACE, LLP | $5.3M | 159,889 | 0.00% | 21q | +1.5%+$78.9K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $5.3M | 172,086 | 0.00% | 11q | -3.9%-$215.1K |
| WELLS FARGO & COMPANY/MN | $5.3M | 157,643 | 0.00% | 31q | +129.2%+$3.0M |
| BOOTHBAY FUND MANAGEMENT, LLC | $5.2M | 156,612 | 0.07% | 8q | +10.3%+$488.6K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $5.2M | 156,809 | 0.01% | 9q | +119.3%+$2.8M |
| BARCLAYS PLC | $5.2M | 154,876 | 0.00% | 31q | -38.0%-$3.2M |
| Eversept Partners, LP | $5.1M | 154,130 | 0.27% | 3q | +146.3%+$3.1M |
| Ghisallo Capital Management LLC | $5.0M | 150,000 | 0.10% | new | NEW |
| Corient Private Wealth LP | $4.9M | 146,493 | 0.01% | 2q | +7.3%+$332.2K |
| Mariner, LLC | $4.9M | 146,400 | 0.01% | 3q | +138.8%+$2.8M |
| FRED ALGER MANAGEMENT, LLC | $4.8M | 143,155 | 0.02% | 31q | -52.0%-$5.2M |
| SR One Capital Management, LP | $4.6M | 137,753 | 0.44% | 3q | HELD |
| B Group, Inc. | $4.5M | 135,000 | 2.12% | 7q | HELD |
| PINNACLE ASSOCIATES LTD | $4.4M | 131,104 | 0.05% | 28q | +27.6%+$948.1K |
| MOORE CAPITAL MANAGEMENT, LP | $4.3M | 128,035 | 0.06% | 14q | -18.5%-$971.5K |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-10-30 | 13G/A | Vanguard Portfolio Management | 8.6% |
| 2026-10-20 | 13G | Madison Avenue International LPwith 5 co-filers | 6.4% |
What the company announced
Form 8-K filings from the last 120 days, showing only the items worth a reader's attention. Earnings releases, exhibit attachments and general disclosures are filed constantly and are left out. Filed is when the SEC received it; event is the date the company says the thing happened.
| Filed | Event date | What | Source |
|---|---|---|---|
| 2026-10-14 | 2026-10-08 | Material agreement entered | filing |
| 2026-10-07 | 2026-10-06 | Material agreement entered | filing |
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-07-01 | Horn Howard | Chief Financial Officer | Sold | 4,698 | $155.6K |
| 2026-05-18 | SULIMAN SHEHNAAZ | Director | Sold | 5,740 | $144.2K |
| 2026-08-03 | Horn Howard | Chief Financial Officer | Sold | 4,696 | $117.0K |
| 2026-06-01 | Horn Howard | Chief Financial Officer | Sold | 4,653 | $110.6K |
| 2026-10-15 | Horn Howard | Chief Financial Officer | Sold | 7,066 | $107.9K |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 44 | $21.2M | 1,411,465 | 6 | 18 | 13 | 0.0% |
| Q2 2026 | 319 | $3.7B | 106,904,688 | 59 | 115 | 102 | 3.4% |
| Q1 2026 | 299 | $2.1B | 98,286,891 | 54 | 125 | 81 | 2.5% |
| Q4 2025 | 298 | $2.3B | 93,971,503 | 44 | 109 | 95 | 5.4% |
| Q3 2025 | 313 | $3.1B | 99,511,087 | 56 | 129 | 90 | 3.9% |
| Q2 2025 | 317 | $3.7B | 94,155,038 | 53 | 114 | 105 | 6.5% |
| Q1 2025 | 306 | $3.3B | 89,888,821 | 33 | 120 | 97 | 2.6% |
| Q4 2024 | 318 | $3.8B | 87,577,299 | 41 | 108 | 103 | 1.9% |
| Q3 2024 | 306 | $4.9B | 87,121,452 | 61 | 104 | 93 | 1.1% |
| Q2 2024 | 274 | $3.7B | 88,858,961 | 45 | 113 | 75 | 1.1% |
| Q1 2024 | 274 | $3.8B | 81,184,176 | 54 | 92 | 70 | 1.3% |
| Q4 2023 | 241 | $3.9B | 81,605,277 | 39 | 95 | 73 | 1.2% |
| Q3 2023 | 224 | $2.6B | 71,347,908 | 10 | 98 | 70 | 1.0% |
| Q2 2023 | 247 | $3.2B | 69,517,770 | 42 | 89 | 77 | 0.9% |
| Q1 2023 | 232 | $2.8B | 70,166,344 | 31 | 87 | 72 | 0.7% |
| Q4 2022 | 231 | $3.2B | 68,016,420 | 36 | 97 | 64 | 1.1% |
| Q3 2022 | 224 | $7.8B | 187,679,263 | 45 | 84 | 53 | 0.4% |
| Q2 2022 | 218 | $11.4B | 190,411,578 | 32 | 78 | 68 | 0.2% |
| Q1 2022 | 234 | $6.5B | 89,945,022 | 38 | 81 | 65 | 0.3% |
| Q4 2021 | 226 | $7.6B | 89,952,509 | 30 | 87 | 65 | 0.1% |
| Q3 2021 | 216 | $7.8B | 87,304,755 | 20 | 79 | 73 | 0.1% |
| Q2 2021 | 236 | $8.9B | 93,504,481 | 41 | 74 | 84 | 0.2% |
| Q1 2021 | 255 | $12.1B | 105,915,148 | 40 | 84 | 94 | 0.5% |
| Q4 2020 | 255 | $12.2B | 87,629,764 | 59 | 92 | 68 | 0.8% |
| Q3 2020 | 205 | $11.3B | 136,996,055 | 33 | 74 | 65 | 0.1% |
| Q2 2020 | 192 | $16.3B | 210,843,135 | 36 | 63 | 64 | 0.2% |
| Q1 2020 | 172 | $4.6B | 103,507,766 | 29 | 65 | 46 | 0.6% |
| Q4 2019 | 168 | $7.4B | 171,781,825 | 23 | 69 | 48 | 0.2% |
| Q3 2019 | 168 | $7.4B | 172,349,899 | 26 | 68 | 45 | 0.1% |
| Q2 2019 | 166 | $11.0B | 173,335,359 | 21 | 71 | 40 | 0.4% |
| Q1 2019 | 175 | $11.9B | 172,180,953 | 37 | 83 | 32 | 0.3% |
| Q4 2018 | 157 | $6.6B | 155,414,411 | 4 | 3 | 3 | 0.1% |