DaveManuel.com · Institutional Ownership · Who Owns It
SEPTERNA INC (SEPN)
Institutional ownership reported to the SEC as of Q2 2026, across 8 quarters.
158
Reporting holders
$1.6B
Reported value
101.6%
Of shares outstanding
2.1%
Calls
0.8%
Puts
+31
Holder change
Institutions report 47,439,068 shares against 46,676,947 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234.3M | 6,995,858 | 2.04% | 7q | HELD |
| TRV GP V, LLC | $208.2M | 6,215,591 | 41.78% | 7q | HELD |
| Driehaus Capital Management LLC | $148.5M | 4,433,058 | 0.86% | 7q | +0.9%+$1.3M |
| TRV GP VI, LLC | $141.0M | 4,211,659 | 60.72% | 7q | HELD |
| SAMSARA BIOCAPITAL, LLC | $105.5M | 3,149,128 | 8.66% | 7q | HELD |
| GOLDMAN SACHS GROUP INC | $102.6M | 3,062,766 | 0.01% | 7q | +5.4%+$5.2M |
| BlackRock, Inc. | $64.7M | 1,932,088 | 0.00% | 7q | +6.0%+$3.7M |
| Siren, L.L.C. | $63.6M | 1,900,000 | 1.29% | 7q | -5.0%-$3.3M |
| Avoro Capital Advisors LLC | $44.8M | 1,337,500 | 0.40% | 7q | HELD |
| Jupiter Topco LLC | $43.7M | 1,307,500 | 0.02% | new | FIRST |
| VANGUARD CAPITAL MANAGEMENT LLC | $40.9M | 1,221,673 | 0.00% | 2q | +2.1%+$827.6K |
| PRIMECAP MANAGEMENT CO/CA/ | $39.1M | 1,167,382 | 0.02% | 3q | +11.3%+$4.0M |
| First Light Asset Management, LLC | $32.3M | 963,260 | 1.96% | 3q | +31.4%+$7.7M |
| ADAR1 Capital Management, LLC | $31.5M | 940,747 | 1.44% | 6q | -13.7%-$5.0M |
| GEODE CAPITAL MANAGEMENT, LLC | $22.8M | 679,163 | 0.00% | 7q | +5.3%+$1.1M |
| Caption Management, LLC | $22.7M incl. $21.4M options CALL+PUT | 38,006 | 0.11% | new | NEW |
| STATE STREET CORP | $21.9M | 652,630 | 0.00% | 7q | +3.4%+$709.4K |
| LOOMIS SAYLES & CO L P | $20.9M | 624,752 | 0.03% | new | NEW |
| Casdin Capital, LLC | $18.5M | 553,268 | 0.93% | 7q | HELD |
| Catalio Capital Management, LP | $18.0M | 536,152 | 3.37% | 7q | +82.1%+$8.1M |
| ALGERT GLOBAL LLC | $13.3M | 397,487 | 0.16% | 3q | +1789.6%+$12.6M |
| Kalehua Capital Management LLC | $13.0M | 389,088 | 4.16% | 3q | HELD |
| Balyasny Asset Management L.P. | $11.7M | 350,442 | 0.01% | 3q | +48.1%+$3.8M |
| TUDOR INVESTMENT CORP ET AL | $11.0M incl. $10.0M options CALL+PUT | 28,966 | 0.02% | new | NEW |
| Longaeva Partners L.P. | $10.0M | 298,171 | 0.22% | 4q | +299.9%+$7.5M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9.9M CALL+PUT | options only | 0.00% | 6q | OPTIONS |
| Soleus Capital Management, L.P. | $9.2M | 275,000 | 0.32% | 7q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7.7M | 230,184 | 0.00% | 2q | +18.0%+$1.2M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7.5M | 222,702 | 0.01% | 7q | -0.6%-$43.3K |
| TWO SIGMA INVESTMENTS, LP | $7.4M | 220,885 | 0.01% | 6q | +193.1%+$4.9M |
| NORTHERN TRUST CORP | $6.7M | 201,131 | 0.00% | 7q | +22.2%+$1.2M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6.3M | 187,041 | 0.00% | 7q | +3.0%+$182.9K |
| Woodline Partners LP | $6.2M | 185,535 | 0.02% | new | NEW |
| VANGUARD FIDUCIARY TRUST CO | $5.5M | 165,656 | 0.00% | 2q | +7.2%+$374.2K |
| MORGAN STANLEY | $4.5M | 134,377 | 0.00% | 7q | +21.6%+$798.6K |
| JANE STREET GROUP, LLC | $3.4M incl. $1.9M options CALL | 45,552 | 0.00% | new | NEW |
| UBS Group AG | $3.0M | 89,874 | 0.00% | 7q | -23.2%-$907.7K |
| JPMORGAN CHASE & CO | $3.0M | 85,301 | 0.00% | 7q | +0.7%+$21.8K |
| CITADEL ADVISORS LLC | $3.0M incl. $2.7M options CALL | 6,350 | 0.00% | new | NEW |
| FEDERATED HERMES, INC. | $2.9M | 86,753 | 0.00% | 3q | -2.9%-$85.3K |
| LAZARD ASSET MANAGEMENT LLC | $2.5M | 75,425 | 0.00% | new | NEW |
| DIMENSIONAL FUND ADVISORS LP | $2.5M | 75,309 | 0.00% | new | NEW |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2.5M | 74,649 | 0.00% | new | NEW |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2.3M | 68,180 | 0.01% | 4q | +139.8%+$1.3M |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2.1M | 63,000 | 0.49% | 2q | -40.0%-$1.4M |
| AMERICAN CENTURY COMPANIES INC | $2.0M | 60,973 | 0.00% | 4q | -0.5%-$10.6K |
| DIADEMA PARTNERS LP | $2.0M PUT | options only | 0.25% | 2q | OPTIONS |
| Bank of New York Mellon Corp | $1.9M | 56,176 | 0.00% | 7q | -4.3%-$84.8K |
| XTX Topco Ltd | $1.8M | 54,489 | 0.02% | 3q | +48.4%+$595.0K |
| MILLENNIUM MANAGEMENT LLC | $1.7M | 50,562 | 0.00% | 6q | -59.3%-$2.5M |
| BARCLAYS PLC | $1.7M | 49,821 | 0.00% | 7q | +119.3%+$907.8K |
| Elmind Capital, LP | $1.7M | 49,444 | 0.42% | new | NEW |
| Nuveen, LLC | $1.6M | 48,229 | 0.00% | 6q | +65.3%+$638.1K |
| Sofinnova Investments, Inc. | $1.6M | 47,506 | 0.08% | 2q | HELD |
| D. E. Shaw & Co., Inc. | $1.6M | 46,483 | 0.00% | new | NEW |
| Voleon Capital Management LP | $1.5M | 44,435 | 0.03% | new | NEW |
| HRT FINANCIAL LP | $1.4M | 42,022 | 0.00% | new | NEW |
| RENAISSANCE TECHNOLOGIES LLC | $1.4M | 41,419 | 0.00% | 2q | +9.9%+$124.5K |
| Russell Investments Group, Ltd. | $1.3M | 40,209 | 0.00% | 4q | +249.2%+$961.0K |
| BANK OF AMERICA CORP /DE/ | $1.2M | 35,875 | 0.00% | 7q | +38.1%+$331.6K |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.2M | 35,323 | 0.00% | 7q | +25.8%+$242.7K |
| Alyeska Investment Group, L.P. | $1.2M | 35,000 | 0.00% | 7q | HELD |
| Brevan Howard Capital Management LP | $986.3K | 29,452 | 0.01% | new | NEW |
| HighVista Strategies LLC | $982.5K | 29,337 | 0.22% | new | NEW |
| RHUMBLINE ADVISERS | $925.5K | 27,636 | 0.00% | 7q | +3.9%+$34.6K |
| Trexquant Investment LP | $858.9K | 25,645 | 0.01% | 3q | -27.4%-$323.4K |
| Invesco Ltd. | $806.9K | 24,094 | 0.00% | 7q | -70.9%-$2.0M |
| Logos Global Management LP | $788.6K | 23,548 | 0.03% | 7q | HELD |
| FMR LLC | $778.3K | 23,240 | 0.00% | 7q | -0.9%-$6.9K |
| FOX RUN MANAGEMENT, L.L.C. | $738.1K | 22,038 | 0.12% | new | NEW |
| DEUTSCHE BANK AG\ | $732.5K | 21,873 | 0.00% | 7q | +29.9%+$168.5K |
| ALLIANCEBERNSTEIN L.P. | $718.5K | 29,900 | 0.00% | 5q | +52.6%+$247.5K |
| Squarepoint Ops LLC | $710.6K | 21,219 | 0.00% | 3q | +17.3%+$105.0K |
| STRS OHIO | $703.3K | 21,000 | 0.00% | 3q | +22.1%+$127.3K |
| FRED ALGER MANAGEMENT, LLC | $701.9K | 20,958 | 0.00% | new | NEW |
| ACADIAN ASSET MANAGEMENT LLC | $701.0K | 20,996 | 0.00% | 3q | -32.2%-$333.3K |
| Jump Financial, LLC | $676.5K | 20,200 | 0.01% | 3q | -61.9%-$1.1M |
| Swiss National Bank | $663.1K | 19,800 | 0.00% | 2q | -10.4%-$77.0K |
| WELLS FARGO & COMPANY/MN | $659.2K | 19,684 | 0.00% | 7q | +99.5%+$328.7K |
| FRANKLIN RESOURCES INC | $623.1K | 18,607 | 0.00% | new | NEW |
| CITIGROUP INC | $596.4K | 17,808 | 0.00% | 7q | +93.7%+$288.4K |
| Aquatic Capital Management LLC | $583.6K | 17,427 | 0.02% | new | NEW |
| Engineers Gate Manager LP | $581.1K | 17,350 | 0.01% | 2q | +5.0%+$27.5K |
| BNP PARIBAS FINANCIAL MARKETS | $567.5K | 16,946 | 0.00% | 7q | +216.1%+$388.0K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555.8K | 16,597 | 0.00% | 3q | +16.8%+$79.8K |
| State of Wyoming | $548.5K | 16,379 | 0.06% | new | NEW |
| Vanguard Global Advisers, LLC | $544.1K | 16,247 | 0.00% | 2q | HELD |
| AQR CAPITAL MANAGEMENT LLC | $515.6K | 15,397 | 0.00% | 3q | HELD |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $445.4K | 13,300 | 0.00% | new | NEW |
| Verdad Advisers, LP | $434.4K | 12,970 | 0.42% | new | NEW |
| MetLife Investment Management, LLC | $431.4K | 12,880 | 0.00% | 5q | -5.9%-$27.0K |
| OSAIC HOLDINGS, INC. | $421.8K | 12,594 | 0.00% | 5q | -0.8%-$3.5K |
| Man Group plc | $384.1K | 11,469 | 0.00% | 2q | -3.3%-$13.0K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $363.9K | 10,866 | 0.00% | 7q | +839.2%+$325.2K |
| China Universal Asset Management Co., Ltd. | $360.8K | 10,774 | 0.02% | 3q | -9.8%-$39.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341.4K | 10,193 | 0.00% | 7q | +1.7%+$5.8K |
| Legal & General Group Plc | $337.0K | 10,062 | 0.00% | 7q | +75.4%+$144.9K |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $334.3K | 9,982 | 0.00% | 2q | -3.9%-$13.4K |
| Gotham Asset Management, LLC | $312.2K | 9,322 | 0.00% | new | NEW |
| Virtus Investment Advisers, LLC | $304.8K | 9,102 | 0.07% | 3q | -15.1%-$54.2K |
Showing the largest 100 of 158 reported holders.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-08-11 | Bhatt Elizabeth | President and COO | Sold | 25,000 | $1.1M |
| 2026-06-22 | Long Daniel D. | SVP, Drug Discovery | Sold | 15,000 | $532.6K ×2 |
| 2026-05-26 | Shaikhly Samira | Chief People Officer | Sold | 11,798 | $354.7K |
| 2026-06-12 | Shaikhly Samira | Chief People Officer | Sold | 6,250 | $219.2K |
| 2026-06-01 | Shaikhly Samira | Chief People Officer | Sold | 5,935 | $171.7K ×3 |
| 2026-10-15 | Bhatt Elizabeth | President and COO | Sold | 4,000 | $149.6K ×2 |
| 2026-07-15 | Bhatt Elizabeth | President and COO | Sold | 4,000 | $136.0K |
| 2026-09-01 | Long Daniel D. | SVP, Drug Discovery | Sold | 3,333 | $126.1K |
| 2026-08-03 | Long Daniel D. | SVP, Drug Discovery | Sold | 3,334 | $114.9K ×2 |
| 2026-07-01 | Long Daniel D. | SVP, Drug Discovery | Sold | 3,333 | $114.5K ×2 |
Ten percent owners and entities
Usually an institution that crossed a reporting threshold, or a company taking a strategic stake, rather than an individual with a view.
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-08-12 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% owner | Sold | 1,493,000 | $63.5M ×2 |
| 2026-08-12 | Third Rock Ventures V, L.P. | 10% owner | Sold | 147,200 | $7.4M ×2 |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 21 | $3.1M | 80,456 | 5 | 8 | 2 | 0.0% |
| Q2 2026 | 158 | $1.6B | 47,439,068 | 47 | 48 | 34 | 2.9% |
| Q1 2026 | 127 | $1.1B | 45,917,507 | 22 | 42 | 30 | 0.2% |
| Q4 2025 | 125 | $1.3B | 45,589,325 | 39 | 29 | 27 | 0.6% |
| Q3 2025 | 87 | $853.9M | 44,559,064 | 10 | 31 | 18 | 1.8% |
| Q2 2025 | 91 | $482.7M | 44,433,609 | 29 | 29 | 19 | 2.7% |
| Q1 2025 | 73 | $262.9M | 45,291,611 | 18 | 24 | 14 | 0.2% |
| Q4 2024 | 72 | $1.0B | 44,130,683 | 67 | 0 | 0 | 0.0% |