DaveManuel.com · Institutional Ownership · Who Owns It
TAYSHA GENE THERAPIES INC (TSHA)
Institutional ownership reported to the SEC as of Q2 2026, across 25 quarters.
208
Reporting holders
$2.1B
Reported value
91.9%
Of shares outstanding
0.2%
Calls
0.1%
Puts
+15
Holder change
Institutions report 299,591,535 shares against 325,833,545 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | $162.7M | 23,888,888 | 1.46% | 12q | +10.1%+$14.9M |
| RA CAPITAL MANAGEMENT, L.P. | $160.4M | 23,555,648 | 1.39% | 12q | HELD |
| GOLDMAN SACHS GROUP INC | $154.7M | 22,713,118 | 0.01% | 11q | +1.5%+$2.3M |
| BlackRock, Inc. | $140.9M | 20,691,927 | 0.00% | 8q | +12.7%+$15.8M |
| Vestal Point Capital, LP | $132.2M | 19,415,000 | 3.09% | 5q | +7.9%+$9.6M |
| MORGAN STANLEY | $112.3M | 16,487,479 | 0.01% | 23q | -8.2%-$10.1M |
| RTW INVESTMENTS, LP | $92.3M | 13,560,258 | 0.79% | 12q | -0.9%-$817.1K |
| FMR LLC | $90.8M | 13,336,413 | 0.00% | 24q | -6.9%-$6.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | $85.0M | 12,478,595 | 0.00% | 2q | +22.0%+$15.3M |
| STATE STREET CORP | $77.8M | 11,421,920 | 0.00% | 23q | +1.9%+$1.4M |
| Siren, L.L.C. | $67.1M | 9,846,579 | 1.36% | 8q | +11.5%+$6.9M |
| Octagon Capital Advisors LP | $66.0M | 9,693,244 | 5.93% | 10q | +9.4%+$5.7M |
| GEODE CAPITAL MANAGEMENT, LLC | $44.7M | 6,560,394 | 0.00% | 23q | +18.6%+$7.0M |
| Polar Capital Holdings Plc | $34.8M | 5,117,133 | 0.08% | 12q | -9.5%-$3.7M |
| MPM BIOIMPACT LLC | $30.6M | 4,500,000 | 1.87% | new | NEW |
| D. E. Shaw & Co., Inc. | $30.0M | 4,398,652 | 0.01% | 5q | -0.6%-$195.1K |
| BAKER BROS. ADVISORS LP | $27.3M | 4,004,756 | 0.14% | 12q | HELD |
| WELLINGTON MANAGEMENT GROUP LLP | $27.1M | 3,975,605 | 0.00% | 8q | +534.7%+$22.8M |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $26.5M | 3,885,501 | 0.04% | 3q | +34.8%+$6.8M |
| GordonMD Global Investments LP | $24.5M | 723,185 | 11.86% | 3q | -1.9%-$486.7K |
| Casdin Capital, LLC | $22.1M | 3,250,000 | 1.11% | 3q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $21.4M | 3,140,009 | 0.00% | 2q | +55.3%+$7.6M |
| ADAR1 Capital Management, LLC | $20.7M | 3,040,466 | 0.95% | 11q | +2.0%+$415.7K |
| Pictet Asset Management Holding SA | $18.9M | 2,770,701 | 0.02% | 3q | +14242.6%+$18.7M |
| Aberdeen Group plc | $15.8M | 2,327,152 | 0.02% | 3q | +127.9%+$8.9M |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $15.3M | 2,250,000 | 0.07% | new | NEW |
| NORGES BANK | $15.2M | 2,233,600 | 0.00% | 2q | +21.5%+$2.7M |
| NORTHERN TRUST CORP | $15.2M | 2,226,210 | 0.00% | 23q | +22.7%+$2.8M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $15.0M | 2,200,695 | 0.00% | 23q | +21.7%+$2.7M |
| MILLENNIUM MANAGEMENT LLC | $14.5M | 2,126,838 | 0.01% | 7q | -35.2%-$7.9M |
| ORBIMED ADVISORS LLC | $13.6M | 2,000,000 | 0.25% | new | NEW |
| RICE HALL JAMES & ASSOCIATES, LLC | $13.6M | 1,992,229 | 0.66% | 4q | +2.4%+$323.9K |
| VANGUARD FIDUCIARY TRUST CO | $12.9M | 1,896,474 | 0.00% | 2q | +23.9%+$2.5M |
| B Group, Inc. | $12.3M | 1,800,556 | 5.76% | 7q | HELD |
| Affinity Asset Advisors, LLC | $11.9M | 1,750,000 | 0.54% | 5q | +75.0%+$5.1M |
| CITADEL ADVISORS LLC | $11.7M incl. $1.2M options CALL+PUT | 1,535,287 | 0.00% | 19q | +273.4%+$8.5M |
| BARCLAYS PLC | $11.1M | 1,630,659 | 0.00% | 9q | -42.0%-$8.0M |
| HEIGHTS CAPITAL MANAGEMENT, INC | $10.2M | 1,500,000 | 2.36% | new | NEW |
| Seven Fleet Capital Management LP | $9.9M | 1,504,400 | 1.64% | 3q | +140.4%+$5.8M |
| Palo Alto Investors LP | $9.5M | 1,391,382 | 1.31% | 11q | HELD |
| BANK OF AMERICA CORP /DE/ | $9.3M | 1,372,845 | 0.00% | 23q | -18.1%-$2.1M |
| Granahan Investment Management, LLC | $8.9M | 1,305,177 | 0.32% | 9q | +47.8%+$2.9M |
| Quantum Private Wealth, LLC | $5.5M | 812,027 | 1.42% | 19q | -4.4%-$253.2K |
| FIRST TRUST ADVISORS LP | $5.4M | 791,169 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $5.2M | 766,282 | 0.00% | 23q | +1.5%+$77.4K |
| Sands Capital Alternatives, LLC | $4.9M | 724,873 | 0.80% | 20q | HELD |
| Bank of New York Mellon Corp | $4.8M | 697,971 | 0.00% | 9q | +14.8%+$611.9K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4.6M incl. $4.5M options CALL+PUT | 27,164 | 0.00% | 12q | -76.6%-$15.3M |
| BNP PARIBAS FINANCIAL MARKETS | $4.4M | 640,035 | 0.00% | 7q | +432.5%+$3.5M |
| PANAGORA ASSET MANAGEMENT INC | $4.0M | 590,387 | 0.01% | 3q | +224.1%+$2.8M |
| UBS Group AG | $4.0M | 588,427 | 0.00% | 24q | +13.7%+$481.7K |
| AFFINITY WEALTH MANAGEMENT LLC | $3.9M | 576,808 | 0.51% | new | NEW |
| Squarepoint Ops LLC | $3.9M | 569,269 | 0.00% | 5q | +38.8%+$1.1M |
| ACUTA CAPITAL PARTNERS, LLC | $3.8M | 561,808 | 2.67% | 5q | +27.8%+$833.2K |
| Nuveen, LLC | $3.8M | 555,693 | 0.00% | 6q | +1.2%+$44.5K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3.8M | 553,000 | 0.01% | new | NEW |
| DIADEMA PARTNERS LP | $3.6M | 522,619 | 0.45% | new | NEW |
| Hennion & Walsh Asset Management, Inc. | $3.5M | 519,120 | 0.10% | 3q | +32.6%+$869.3K |
| Woodline Partners LP | $3.5M | 513,828 | 0.01% | 9q | HELD |
| Holocene Advisors, LP | $3.5M | 510,000 | 0.01% | new | NEW |
| Ghisallo Capital Management LLC | $3.4M | 505,000 | 0.07% | new | NEW |
| Burkehill Global Management, LP | $3.4M | 500,000 | 0.12% | new | NEW |
| POLEN CAPITAL MANAGEMENT LLC | $3.3M | 489,219 | 0.03% | 3q | +53.0%+$1.2M |
| DIMENSIONAL FUND ADVISORS LP | $3.2M | 464,771 | 0.00% | 4q | -5.2%-$174.9K |
| VOYA INVESTMENT MANAGEMENT LLC | $2.9M | 425,363 | 0.00% | 9q | -16.9%-$589.9K |
| Trexquant Investment LP | $2.6M | 379,577 | 0.02% | new | NEW |
| Swiss National Bank | $2.5M | 369,000 | 0.00% | 3q | +37.3%+$682.4K |
| MOORE CAPITAL MANAGEMENT, LP | $2.4M | 358,374 | 0.04% | 2q | +9.0%+$201.2K |
| WELLS FARGO & COMPANY/MN | $2.3M | 333,314 | 0.00% | 19q | +81.8%+$1.0M |
| Jefferies Financial Group Inc. | $2.2M | 328,800 | 0.01% | 6q | -31.4%-$1.0M |
| CITIGROUP INC | $2.1M | 306,907 | 0.00% | 12q | +437.7%+$1.7M |
| RHUMBLINE ADVISERS | $2.0M | 299,975 | 0.00% | 9q | +16.0%+$282.2K |
| ALPS ADVISORS INC | $2.0M | 290,543 | 0.01% | 3q | +30.3%+$460.1K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1.9M | 272,600 | 0.00% | 3q | +2.6%+$46.3K |
| JANE STREET GROUP, LLC | $1.8M incl. $260.1K options CALL | 228,355 | 0.00% | 5q | HELD |
| Invesco Ltd. | $1.8M | 264,379 | 0.00% | 9q | -28.2%-$705.8K |
| Ensign Peak Advisors, Inc | $1.8M | 262,896 | 0.00% | 3q | -4.4%-$83.2K |
| Qube Research & Technologies Ltd | $1.8M | 259,605 | 0.00% | new | NEW |
| SPHERA FUNDS MANAGEMENT LTD. | $1.7M | 250,000 | 0.22% | new | NEW |
| DEUTSCHE BANK AG\ | $1.7M | 243,379 | 0.00% | 9q | +33.9%+$419.6K |
| TWO SIGMA INVESTMENTS, LP | $1.6M | 234,716 | 0.00% | 5q | -68.4%-$3.5M |
| SG Americas Securities, LLC | $1.4M | 202,260 | 0.00% | 5q | -90.7%-$13.4M |
| Monashee Investment Management LLC | $1.4M | 200,000 | 2.29% | new | NEW |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1.4M | 199,494 | 0.00% | 12q | +25.5%+$276.2K |
| Privium Fund Management B.V. | $1.4M | 198,900 | 0.25% | 9q | +9.3%+$115.8K |
| VICTORY CAPITAL MANAGEMENT INC | $1.3M | 197,578 | 0.00% | 11q | +0.9%+$12.5K |
| Chicago Partners Investment Group LLC | $1.3M | 222,347 | 0.03% | 12q | +30.2%+$300.8K |
| Balyasny Asset Management L.P. | $1.3M | 189,332 | 0.00% | 3q | +128.1%+$724.0K |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.2M | 177,089 | 0.00% | 4q | -32.8%-$587.3K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1.2M | 169,374 | 0.00% | 9q | +23.7%+$220.9K |
| RAYMOND JAMES FINANCIAL INC | $1.1M | 166,042 | 0.00% | 3q | +653.7%+$980.7K |
| ALLIANCEBERNSTEIN L.P. | $1.1M | 247,680 | 0.00% | 9q | +30.9%+$261.2K |
| WEXFORD CAPITAL LP | $1.1M | 160,654 | 0.14% | 4q | HELD |
| Rafferty Asset Management, LLC | $1.1M | 154,706 | 0.00% | 5q | -48.4%-$988.8K |
| Palumbo Wealth Management LLC | $1.0M | 149,173 | 0.21% | 4q | +1.7%+$16.8K |
| MetLife Investment Management, LLC | $959.2K | 140,846 | 0.00% | 9q | +17.3%+$141.2K |
| Vanguard Global Advisers, LLC | $911.3K | 133,821 | 0.00% | 2q | +14.7%+$116.7K |
| Persistent Asset Partners Ltd | $908.5K | 133,411 | 0.27% | new | NEW |
| VANGUARD ASSET MANAGEMENT, Ltd | $903.1K | 132,614 | 0.00% | 2q | +46.6%+$287.0K |
| AQR CAPITAL MANAGEMENT LLC | $876.9K | 128,764 | 0.00% | 8q | -27.4%-$330.6K |
Showing the largest 100 of 208 reported holders.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-07-10 | Nagendran Sukumar | President and Head of R&D | Sold | 200,000 | $1.2M |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 29 | $9.5M | 1,999,595 | 4 | 13 | 3 | 0.0% |
| Q2 2026 | 208 | $2.1B | 299,591,535 | 40 | 99 | 41 | 0.3% |
| Q1 2026 | 193 | $1.2B | 265,721,411 | 25 | 68 | 47 | 0.2% |
| Q4 2025 | 197 | $1.5B | 269,030,144 | 64 | 61 | 43 | 0.6% |
| Q3 2025 | 154 | $869.5M | 265,049,921 | 27 | 55 | 34 | 0.3% |
| Q2 2025 | 150 | $597.2M | 258,275,405 | 45 | 46 | 32 | 0.1% |
| Q1 2025 | 128 | $232.2M | 166,902,469 | 22 | 33 | 29 | 0.1% |
| Q4 2024 | 130 | $290.0M | 167,484,290 | 23 | 42 | 25 | 0.1% |
| Q3 2024 | 117 | $321.7M | 159,987,044 | 30 | 42 | 15 | 0.0% |
| Q2 2024 | 107 | $361.2M | 161,115,821 | 35 | 28 | 21 | 0.1% |
| Q1 2024 | 110 | $433.0M | 150,608,076 | 37 | 29 | 26 | 0.2% |
| Q4 2023 | 87 | $231.1M | 130,390,904 | 26 | 30 | 10 | 0.1% |
| Q3 2023 | 64 | $412.1M | 129,978,171 | 37 | 13 | 7 | 0.4% |
| Q2 2023 | 39 | $9.1M | 13,704,237 | 3 | 8 | 11 | 0.1% |
| Q1 2023 | 43 | $15.8M | 19,776,725 | 5 | 13 | 11 | 0.0% |
| Q4 2022 | 52 | $44.1M | 19,375,255 | 14 | 20 | 9 | 0.6% |
| Q3 2022 | 53 | $27.2M | 13,929,748 | 2 | 11 | 21 | 0.7% |
| Q2 2022 | 58 | $54.8M | 14,701,866 | 15 | 14 | 23 | 0.2% |
| Q1 2022 | 70 | $111.1M | 17,004,141 | 14 | 26 | 14 | 0.2% |
| Q4 2021 | 63 | $300.2M | 25,766,616 | 20 | 22 | 6 | 0.0% |
| Q3 2021 | 47 | $501.8M | 26,949,807 | 4 | 19 | 11 | 0.0% |
| Q2 2021 | 47 | $400.3M | 18,881,312 | 9 | 26 | 3 | 0.0% |
| Q1 2021 | 46 | $363.6M | 17,910,792 | 3 | 16 | 13 | 0.0% |
| Q4 2020 | 51 | $481.8M | 18,248,353 | 23 | 8 | 8 | 0.0% |
| Q3 2020 | 45 | $362.2M | 16,380,732 | 45 | 0 | 0 | 0.0% |