DaveManuel.com · Institutional Ownership · Who Owns It
TYRA BIOSCIENCES INC (TYRA)
Institutional ownership reported to the SEC as of Q2 2026, across 21 quarters.
170
Reporting holders
$2.2B
Reported value
116.3%
Of shares outstanding
0.6%
Calls
0.1%
Puts
+6
Holder change
Institutions report 69,413,366 shares against 59,676,939 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $389.6M | 12,198,625 | 3.39% | 20q | HELD |
| FMR LLC | $284.9M | 8,920,513 | 0.01% | 20q | +15.1%+$37.5M |
| Jupiter Topco LLC | $139.2M | 4,352,448 | 0.06% | new | FIRST |
| Alta Partners Management Company, L.P. | $122.1M | 3,823,425 | 95.92% | 7q | HELD |
| Nextech Invest Ltd. | $113.5M | 3,553,585 | 5.39% | 6q | -12.4%-$16.0M |
| TCG Crossover Management, LLC | $103.8M | 3,248,980 | 2.49% | 19q | HELD |
| BlackRock, Inc. | $96.8M | 3,031,972 | 0.00% | 8q | +36.7%+$26.0M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $88.9M | 2,782,567 | 0.01% | 5q | +182.2%+$57.4M |
| STATE STREET CORP | $68.4M | 2,140,368 | 0.00% | 19q | +76.0%+$29.5M |
| Commodore Capital LP | $59.9M | 1,875,000 | 3.57% | 6q | -24.2%-$19.2M |
| Paradigm Biocapital Advisors LP | $58.4M | 1,828,607 | 1.09% | 2q | -11.0%-$7.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | $48.2M | 1,508,447 | 0.00% | 2q | +34.0%+$12.2M |
| BVF INC/IL | $47.1M | 1,476,196 | 1.21% | 20q | -25.3%-$16.0M |
| 5AM Venture Management, LLC | $32.9M | 1,029,298 | 11.42% | 12q | HELD |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $32.5M | 1,017,000 | 0.34% | 2q | +85.2%+$14.9M |
| Hood River Capital Management LLC | $32.5M | 1,016,775 | 0.24% | new | NEW |
| GEODE CAPITAL MANAGEMENT, LLC | $31.0M | 970,734 | 0.00% | 19q | +47.4%+$10.0M |
| Caligan Partners LP | $25.8M | 806,986 | 1.21% | 6q | -36.8%-$15.0M |
| Canaan Partners XI LLC | $24.0M | 750,000 | 18.82% | 19q | HELD |
| Siren, L.L.C. | $23.2M | 725,000 | 0.47% | new | NEW |
| Sio Capital Management, LLC | $22.2M | 695,315 | 3.68% | 10q | +14.8%+$2.9M |
| STEMPOINT CAPITAL LP | $20.2M | 632,754 | 3.48% | 2q | +63.8%+$7.9M |
| MARSHALL WACE, LLP | $18.6M | 583,133 | 0.01% | 8q | +194.9%+$12.3M |
| GOLDMAN SACHS GROUP INC | $14.8M | 463,477 | 0.00% | 10q | -15.8%-$2.8M |
| JENNISON ASSOCIATES LLC | $14.4M | 450,964 | 0.01% | 2q | -28.7%-$5.8M |
| TWO SIGMA INVESTMENTS, LP | $14.4M | 449,808 | 0.01% | 10q | +342.6%+$11.1M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12.9M | 403,019 | 0.00% | 2q | +63.0%+$5.0M |
| Defilade Capital Management, L.P. | $12.0M | 376,870 | 1.61% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $11.2M | 349,732 | 0.00% | 20q | +66.6%+$4.5M |
| Walleye Capital LLC | $11.1M | 347,898 | 0.04% | 2q | +1758.9%+$10.5M |
| Woodline Partners LP | $10.2M | 320,040 | 0.03% | 2q | +6.3%+$606.9K |
| NORTHERN TRUST CORP | $9.9M | 310,084 | 0.00% | 19q | +41.9%+$2.9M |
| MORGAN STANLEY | $9.6M | 300,322 | 0.00% | 19q | +149.3%+$5.7M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9.6M CALL+PUT | options only | 0.00% | 3q | OPTIONS |
| CITADEL ADVISORS LLC | $8.9M | 278,307 | 0.00% | 8q | +1707.7%+$8.4M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8.6M | 267,699 | 0.00% | 19q | +34.4%+$2.2M |
| Qube Research & Technologies Ltd | $8.5M | 266,934 | 0.01% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $7.7M | 240,227 | 0.00% | 7q | +26.4%+$1.6M |
| ALGERT GLOBAL LLC | $7.6M | 239,120 | 0.09% | 3q | +27.2%+$1.6M |
| VANGUARD FIDUCIARY TRUST CO | $7.2M | 224,805 | 0.00% | 2q | +42.5%+$2.1M |
| DIMENSIONAL FUND ADVISORS LP | $6.9M | 217,078 | 0.00% | 8q | +136.4%+$4.0M |
| MILLENNIUM MANAGEMENT LLC | $6.5M incl. $798.5K options CALL | 177,672 | 0.00% | 8q | -19.8%-$1.6M |
| Affinity Asset Advisors, LLC | $6.4M | 200,012 | 0.29% | 2q | -22.3%-$1.8M |
| FRANKLIN RESOURCES INC | $6.1M | 192,340 | 0.00% | 3q | +1383.0%+$5.7M |
| HighVista Strategies LLC | $5.9M | 184,774 | 1.35% | 9q | +40.7%+$1.7M |
| RAYMOND JAMES FINANCIAL INC | $5.8M | 180,881 | 0.00% | 7q | -26.8%-$2.1M |
| JPMORGAN CHASE & CO | $5.7M | 178,263 | 0.00% | 19q | +166.9%+$3.6M |
| BOOTHBAY FUND MANAGEMENT, LLC | $5.5M | 173,559 | 0.07% | 4q | -36.5%-$3.2M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $5.2M | 162,000 | 0.01% | new | NEW |
| Jump Financial, LLC | $5.0M | 157,000 | 0.04% | 2q | +279.5%+$3.7M |
| VICTORY CAPITAL MANAGEMENT INC | $4.9M | 152,585 | 0.00% | 14q | +901.9%+$4.4M |
| Kalehua Capital Management LLC | $4.8M | 148,930 | 1.52% | 3q | HELD |
| Ensign Peak Advisors, Inc | $4.7M | 146,537 | 0.01% | 2q | +97.9%+$2.3M |
| BARCLAYS PLC | $4.3M incl. $3.6M options CALL | 20,275 | 0.00% | 18q | -97.6%-$171.6M |
| Trexquant Investment LP | $4.2M | 132,740 | 0.02% | 2q | -9.9%-$465.6K |
| UBS Group AG | $4.2M | 129,945 | 0.00% | 16q | +111.1%+$2.2M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $3.9M | 123,420 | 0.00% | 3q | -4.2%-$173.8K |
| LORD, ABBETT & CO. LLC | $3.9M | 121,833 | 0.01% | new | NEW |
| Bank of New York Mellon Corp | $3.3M | 103,720 | 0.00% | 19q | +43.6%+$1.0M |
| Russell Investments Group, Ltd. | $3.3M | 102,703 | 0.00% | 13q | +45.8%+$1.0M |
| ORBIMED ADVISORS LLC | $3.3M | 102,000 | 0.06% | new | NEW |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2.8M | 89,205 | 0.01% | 7q | -45.0%-$2.3M |
| OPPENHEIMER & CO INC | $2.7M | 83,783 | 0.03% | 10q | HELD |
| XTX Topco Ltd | $2.6M | 81,320 | 0.03% | 5q | -3.1%-$82.3K |
| Nuveen, LLC | $2.5M | 78,829 | 0.00% | 6q | +55.1%+$894.0K |
| SEI INVESTMENTS CO | $2.1M | 66,607 | 0.00% | new | NEW |
| Squarepoint Ops LLC | $2.0M | 63,805 | 0.00% | 5q | +211.3%+$1.4M |
| CITIGROUP INC | $2.0M | 62,279 | 0.00% | 13q | +939.5%+$1.8M |
| Fisher Asset Management, LLC | $1.9M | 60,230 | 0.00% | 3q | +109.1%+$1.0M |
| ALPS ADVISORS INC | $1.9M | 60,159 | 0.01% | 5q | +37.2%+$520.7K |
| WELLINGTON MANAGEMENT GROUP LLP | $1.9M | 59,601 | 0.00% | 20q | -22.8%-$561.1K |
| ALLIANCEBERNSTEIN L.P. | $1.9M | 48,420 | 0.00% | 9q | +51.4%+$629.3K |
| RHUMBLINE ADVISERS | $1.7M | 52,039 | 0.00% | 18q | +31.2%+$395.4K |
| TD Asset Management Inc | $1.6M | 50,000 | 0.00% | 2q | HELD |
| Arkadios Wealth Advisors | $1.6M | 49,336 | 0.02% | 2q | +3.7%+$56.5K |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.5M | 46,697 | 0.00% | 9q | +40.4%+$429.2K |
| JANE STREET GROUP, LLC | $1.4M PUT | options only | 0.00% | 2q | OPTIONS |
| Susquehanna Portfolio Strategies, LLC | $1.4M | 44,878 | 0.02% | 5q | -4.6%-$68.6K |
| Swiss National Bank | $1.4M | 44,700 | 0.00% | 2q | +69.3%+$584.5K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1.4M | 44,327 | 0.00% | 3q | +10.2%+$131.0K |
| ExodusPoint Capital Management, LP | $1.3M | 41,026 | 0.01% | 3q | +191.7%+$861.1K |
| Rafferty Asset Management, LLC | $1.2M | 38,702 | 0.00% | 3q | +11.0%+$122.8K |
| DEUTSCHE BANK AG\ | $1.2M | 36,935 | 0.00% | 19q | +80.2%+$525.1K |
| Verdad Advisers, LP | $1.1M | 36,003 | 1.10% | new | NEW |
| WELLS FARGO & COMPANY/MN | $1.1M | 33,561 | 0.00% | 14q | +187.5%+$699.1K |
| Sofinnova Investments, Inc. | $1.0M | 32,267 | 0.05% | 2q | -84.2%-$5.5M |
| Engineers Gate Manager LP | $1.0M | 31,958 | 0.01% | new | NEW |
| AQR CAPITAL MANAGEMENT LLC | $953.5K | 29,853 | 0.00% | 5q | +1.5%+$13.7K |
| Tidal Investments LLC | $942.8K | 29,519 | 0.00% | new | NEW |
| Tema ETFs LLC | $942.8K | 29,519 | 0.03% | new | NEW |
| SG Americas Securities, LLC | $940.0K | 29,444 | 0.00% | 2q | +308.1%+$709.7K |
| PDT Partners, LLC | $820.3K | 25,684 | 0.04% | 5q | -39.3%-$530.2K |
| Invesco Ltd. | $795.1K | 24,893 | 0.00% | 4q | -77.2%-$2.7M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $783.9K | 24,544 | 0.00% | 19q | +1650.6%+$739.2K |
| STRS OHIO | $705.9K | 22,100 | 0.00% | 10q | +22.1%+$127.8K |
| Creative Planning | $696.4K | 21,803 | 0.00% | 3q | -9.0%-$68.5K |
| MetLife Investment Management, LLC | $693.8K | 21,723 | 0.00% | 14q | +55.2%+$246.9K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $683.1K | 21,364 | 0.00% | 9q | +46.1%+$215.5K |
| LMR Partners LLP | $675.6K | 21,151 | 0.00% | new | NEW |
| Auour Investments LLC | $671.4K | 21,020 | 0.19% | 13q | HELD |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-10-27 | 13G/A | BlackRock, Inc. | 4.8% |
| 2026-09-21 | 13G | BVF PARTNERS L P/ILwith 9 co-filers | 6.1% |
| 2026-09-17 | 13G | Paradigm BioCapital Advisors LPwith 3 co-filers | 5.8% |
| 2026-09-17 | 13D/A | RA Capital Management, L.P.with 3 co-filers | 19.9% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 22 | $20.6M | 940,571 | 2 | 8 | 6 | 0.0% |
| Q2 2026 | 170 | $2.2B | 69,413,366 | 32 | 72 | 43 | 0.7% |
| Q1 2026 | 164 | $2.6B | 66,205,992 | 39 | 58 | 34 | 0.6% |
| Q4 2025 | 135 | $1.5B | 56,827,612 | 24 | 42 | 37 | 0.0% |
| Q3 2025 | 117 | $779.8M | 55,712,864 | 9 | 39 | 36 | 0.0% |
| Q2 2025 | 121 | $541.7M | 56,604,867 | 19 | 61 | 19 | 0.0% |
| Q1 2025 | 116 | $499.8M | 53,573,458 | 20 | 41 | 30 | 0.1% |
| Q4 2024 | 112 | $675.9M | 48,613,623 | 27 | 34 | 25 | 0.0% |
| Q3 2024 | 96 | $1.1B | 47,422,942 | 27 | 27 | 20 | 0.7% |
| Q2 2024 | 77 | $754.4M | 47,179,452 | 15 | 29 | 16 | 0.0% |
| Q1 2024 | 76 | $775.8M | 47,303,182 | 22 | 26 | 15 | 0.0% |
| Q4 2023 | 66 | $503.1M | 36,194,067 | 10 | 19 | 9 | 0.4% |
| Q3 2023 | 59 | $502.1M | 36,462,633 | 4 | 15 | 16 | 0.0% |
| Q2 2023 | 59 | $616.7M | 36,210,809 | 8 | 18 | 14 | 0.0% |
| Q1 2023 | 51 | $624.2M | 38,802,307 | 10 | 17 | 9 | 0.1% |
| Q4 2022 | 46 | $267.9M | 35,239,863 | 0 | 16 | 12 | 0.0% |
| Q3 2022 | 48 | $412.0M | 46,864,822 | 6 | 15 | 14 | 0.0% |
| Q2 2022 | 45 | $255.6M | 35,744,386 | 3 | 18 | 15 | 0.0% |
| Q1 2022 | 46 | $386.6M | 36,133,976 | 5 | 12 | 17 | 0.0% |
| Q4 2021 | 45 | $503.6M | 35,847,719 | 25 | 8 | 6 | 0.0% |
| Q3 2021 | 26 | $456.8M | 26,080,764 | 25 | 0 | 0 | 0.0% |