Skip to content
DaveManuel.com · Institutional Ownership · Who Owns It

ZYMEWORKS INC (ZYME)

Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.

205
Reporting holders
$1.8B
Reported value
98.1%
Of shares outstanding
0.3%
Calls
0.2%
Puts
-12
Holder change

Institutions report 69,615,039 shares against 70,959,241 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.

Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.

Holders

Download these holders as CSV

FilerValueShares Their book Held Change
EcoR1 Capital, LLC$600.4M22,970,38829.19%15qHELD
Rubric Capital Management LP$183.0M7,000,0001.68%15qHELD
BlackRock, Inc.$111.1M4,251,0300.00%8q-6.7%-$7.9M
PERCEPTIVE ADVISORS LLC$109.3M4,182,9531.64%15q+19.2%+$17.6M
BVF INC/IL$95.4M3,649,1422.44%15q-2.3%-$2.2M
Assenagon Asset Management S.A.$65.5M2,504,0540.04%8q+244.0%+$46.4M
MORGAN STANLEY$58.3M2,231,2600.00%15q-10.1%-$6.5M
BNP PARIBAS ASSET MANAGEMENT Holding S.A.$46.6M1,781,1160.05%3q-6.7%-$3.3M
VANGUARD CAPITAL MANAGEMENT LLC$40.8M1,558,9980.00%2q-8.6%-$3.8M
Nextech Invest Ltd.$29.1M1,113,9461.38%6qHELD
STATE STREET CORP$28.4M1,088,2160.00%15q+7.6%+$2.0M
DIMENSIONAL FUND ADVISORS LP$26.0M994,9550.00%14q-12.7%-$3.8M
CITADEL ADVISORS LLC$25.3M
incl. $1.4M options CALL
914,1360.00%15q-20.5%-$6.5M
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.$23.3M889,8020.03%newNEW
FMR LLC$18.4M702,5680.00%13q+5.3%+$925.7K
GEODE CAPITAL MANAGEMENT, LLC$18.1M692,4100.00%14q+4.9%+$848.7K
Prosight Management, LP$17.6M674,4343.04%10q+25.1%+$3.5M
Qube Research & Technologies Ltd$15.5M593,5900.01%5q+15.9%+$2.1M
VANGUARD PORTFOLIO MANAGEMENT LLC$13.3M510,0320.00%2q+2.0%+$265.5K
Redmile Group, LLC$12.9M491,6540.86%15qHELD
Capricorn Fund Managers Ltd$12.7M486,5291.00%3q-51.7%-$13.6M
GOLDMAN SACHS GROUP INC$12.3M470,8220.00%15q-21.5%-$3.4M
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP$10.9M418,4970.00%4q-43.7%-$8.5M
DEUTSCHE BANK AG\$10.4M397,1900.00%15q-56.9%-$13.7M
Hillsdale Investment Management Inc.$10.0M382,9220.23%7q+10.8%+$975.0K
FIRST TRUST ADVISORS LP$8.9M340,3630.01%newNEW
Granahan Investment Management, LLC$8.8M336,1570.31%15q+34.0%+$2.2M
NORTHERN TRUST CORP$8.4M321,0730.00%15qHELD
Pictet Asset Management Holding SA$7.4M308,1870.01%3q+3229.6%+$7.2M
PICTON MAHONEY ASSET MANAGEMENT$7.1M271,3430.05%15q+5.7%+$383.0K
SUSQUEHANNA INTERNATIONAL GROUP, LLP$5.9M CALL+PUToptions only0.00%15qOPTIONS
SILVERCREST ASSET MANAGEMENT GROUP LLC$5.8M223,7660.04%13q+36.7%+$1.6M
BANK OF AMERICA CORP /DE/$5.7M219,0710.00%15q-7.5%-$462.2K
WELLS FARGO & COMPANY/MN$5.7M217,1990.00%15q+14.5%+$720.5K
SummitTX Capital, L.P.$5.5M210,8020.14%3q-34.4%-$2.9M
Man Group plc$5.5M210,7790.01%6q+11.0%+$546.0K
FEDERATED HERMES, INC.$4.9M187,9950.01%11q+3.1%+$146.0K
RAYMOND JAMES FINANCIAL INC$4.4M166,4160.00%7q-5.7%-$261.3K
STATE OF WISCONSIN INVESTMENT BOARD$4.1M155,5790.01%14q+135.3%+$2.3M
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$4.0M152,4160.00%13q-17.7%-$855.0K
KENNEDY CAPITAL MANAGEMENT LLC$3.8M145,3860.07%16q-1.9%-$74.2K
D. E. Shaw & Co., Inc.$3.8M144,8070.00%10q-38.5%-$2.4M
DIADEMA PARTNERS LP$3.7M142,1320.47%6qHELD
CITIGROUP INC$3.4M131,4410.00%15q+15.0%+$447.4K
Bank of New York Mellon Corp$3.4M131,1060.00%13q+5.6%+$183.0K
XTX Topco Ltd$3.3M125,8770.04%3q-12.5%-$470.7K
Nuveen, LLC$3.1M119,3890.00%6q-81.7%-$13.9M
PANAGORA ASSET MANAGEMENT INC$3.1M118,6030.01%5q-42.7%-$2.3M
UBS Group AG$3.0M115,0950.00%15q-33.0%-$1.5M
Invesco Ltd.$2.9M112,2120.00%13q-10.7%-$350.7K
AQR CAPITAL MANAGEMENT LLC$2.9M111,2820.00%13q+22.7%+$538.8K
WELLINGTON MANAGEMENT GROUP LLP$2.9M110,0140.00%13q-20.7%-$749.6K
Tidal Investments LLC$2.8M105,6150.00%2q+0.7%+$17.9K
Tema ETFs LLC$2.8M105,6150.09%6q+0.7%+$17.9K
PLATINUM INVESTMENT MANAGEMENT LTD$2.7M105,1840.68%15qHELD
Manatuck Hill Partners, LLC$2.6M100,0000.87%2q+150.0%+$1.6M
JPMORGAN CHASE & CO$2.6M106,3980.00%14q-6.7%-$184.9K
KORNITZER CAPITAL MANAGEMENT INC /KS$2.3M88,8000.05%3qHELD
MACKENZIE FINANCIAL CORP$2.3M87,7450.00%5q+6.1%+$131.2K
PRINCIPAL FINANCIAL GROUP INC$2.2M84,9900.00%2q+8.2%+$168.4K
Y-Intercept (Hong Kong) Ltd$2.2M83,4550.04%newNEW
LMR Partners LLP$2.2M82,5000.01%newNEW
AMERIPRISE FINANCIAL INC$2.2M82,2640.00%4q+10.8%+$210.2K
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC$2.1M81,3590.00%14q-74.5%-$6.2M
VANGUARD FIDUCIARY TRUST CO$2.1M80,1200.00%2q-5.1%-$112.0K
STIFEL FINANCIAL CORP$2.0M77,2140.00%15q+0.6%+$12.0K
FRANKLIN RESOURCES INC$2.0M76,5280.00%4q-1.5%-$29.6K
RHUMBLINE ADVISERS$2.0M75,0660.00%13qHELD
Swiss National Bank$1.9M74,2000.00%14qHELD
MARTINGALE ASSET MANAGEMENT L P$1.9M73,2820.05%2q+123.7%+$1.1M
TWO SIGMA INVESTMENTS, LP$1.9M71,8740.00%newNEW
Dana Investment Advisors, Inc.$1.9M71,6600.05%3q+27.7%+$406.6K
CREDIT AGRICOLE S A$1.9M71,0000.00%3q-5.3%-$104.6K
Fisher Asset Management, LLC$1.9M70,7750.00%9q-30.2%-$801.6K
SEGALL BRYANT & HAMILL, LLC$1.7M66,8360.02%2q+46.2%+$551.8K
Verdad Advisers, LP$1.7M66,6881.67%2q-19.4%-$418.5K
Susquehanna Portfolio Strategies, LLC$1.7M65,2480.03%5q-34.6%-$903.1K
Campbell & CO Investment Adviser LLC$1.6M60,8740.08%5q+10.9%+$156.6K
SIMPLEX TRADING, LLC$1.5M
incl. $1.0M options CALL+PUT
19,4310.00%15q+1354.4%+$1.4M
ROYAL BANK OF CANADA$1.5M56,2780.00%15q+18.8%+$233.1K
ALLIANCEBERNSTEIN L.P.$1.4M55,8960.00%13qHELD
Virtus Investment Advisers, LLC$1.3M50,8250.31%6q+374.9%+$1.0M
ENVESTNET ASSET MANAGEMENT INC$1.3M48,6750.00%15q+20.4%+$215.8K
Russell Investments Group, Ltd.$1.3M47,8670.00%15q+0.9%+$10.9K
Quantinno Capital Management LP$1.2M47,6420.00%3q+20.2%+$209.2K
North Growth Management Ltd.$1.2M46,0000.15%15qHELD
Legal & General Group Plc$1.1M43,1600.00%14q+64.7%+$443.0K
VICTORY CAPITAL MANAGEMENT INC$1.1M42,5240.00%10qHELD
MARSHALL WACE, LLP$1.1M40,9480.00%2q+27.1%+$228.1K
O'SHAUGHNESSY ASSET MANAGEMENT, LLC$1.0M39,5340.00%13q+6.5%+$62.9K
PRICE T ROWE ASSOCIATES INC /MD/$1.0M38,4860.00%13q+8.5%+$78.5K
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM$986.6K37,7440.00%14q+0.9%+$9.3K
JACOBS LEVY EQUITY MANAGEMENT, INC$965.1K36,9220.00%2q-13.7%-$153.3K
TUDOR INVESTMENT CORP ET AL$953.4K36,4710.00%5q-1.1%-$10.6K
HighTower Advisors, LLC$943.7K36,1000.00%2qHELD
Persistent Asset Partners Ltd$939.3K35,9350.28%3qHELD
HighVista Strategies LLC$889.1K34,0130.20%2qHELD
COMMONWEALTH EQUITY SERVICES, LLC$837.8K32,0520.00%15q+23.1%+$157.4K
MANUFACTURERS LIFE INSURANCE COMPANY, THE$807.4K30,8860.00%13q-2.2%-$18.5K
Creative Planning$777.2K29,7310.00%7q-8.2%-$69.6K

Showing the largest 100 of 205 reported holders.

What the company announced

Form 8-K filings from the last 120 days, showing only the items worth a reader's attention. Earnings releases, exhibit attachments and general disclosures are filed constantly and are left out. Filed is when the SEC received it; event is the date the company says the thing happened.

FiledEvent dateWhatSource
2026-10-232026-10-22Material agreement enteredfiling
2026-09-232026-09-23Acquisition or disposal completed Material agreement enteredfiling

What the insiders did

Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.

Officers and directors

DateInsiderRoleSideSharesValue
2026-10-09Schayowitz AdamEVP, Head of R&DSold13,832$357.6K

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q3 202631$47.3M1,784,69751330.0%
Q2 2026205$1.8B69,615,0392360690.5%
Q1 2026217$1.8B70,293,3633376550.7%
Q4 2025213$1.9B71,482,9834369641.1%
Q3 2025186$1.3B73,738,0322556581.1%
Q2 2025183$955.0M75,689,8732856520.5%
Q1 2025186$844.8M70,606,7963155630.4%
Q4 2024173$974.0M66,481,0982346610.1%
Q3 2024161$844.3M66,541,5552439501.1%
Q2 2024163$582.6M68,263,1122356520.3%
Q1 2024169$825.7M78,336,1433259390.2%
Q4 2023157$727.2M69,796,1832755350.3%
Q3 2023138$396.9M62,374,1332150350.3%
Q2 2023137$551.5M63,418,6845136320.6%
Q1 2023117$516.7M56,721,6264334260.8%
Q4 202295$453.4M57,230,91695100.8%
Q3 202285$291.5M47,065,5931125240.7%
Q2 2022104$254.3M47,513,3522537261.0%
Q1 2022114$323.8M49,178,1662948190.5%
Q4 2021113$756.2M45,749,8271341240.8%
Q3 2021121$1.5B51,266,9532936260.7%
Q2 2021109$1.3B38,795,059833420.9%
Q1 2021122$1.3B40,890,2391953290.7%
Q4 2020142$2.2B44,948,0303030495.1%
Q3 2020135$1.8B36,891,1182540413.9%
Q2 2020137$2.8B76,666,0204245312.2%
Q1 2020118$2.0B56,826,0163635300.7%
Q4 2019104$2.6B57,490,0923324260.4%
Q3 201973$1.3B53,972,5002221180.2%
Q2 201966$470.1M21,139,287252361.1%
Q1 201949$184.9M11,444,263131580.3%
Q4 201843$132.2M9,085,8094120.2%