DaveManuel.com · Institutional Ownership · Who Owns It
DEFINIUM THERAPEUTICS INC (DFTX)
Institutional ownership reported to the SEC as of Q2 2026, across 4 quarters.
370
Reporting holders
$5.6B
Reported value
85.5%
Of shares outstanding
3.1%
Calls
1.3%
Puts
+120
Holder change
Institutions report 114,855,731 shares against 134,366,950 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| BlackRock, Inc. | $528.4M | 11,232,834 | 0.01% | 2q | +32.5%+$129.5M |
| Avoro Capital Advisors LLC | $338.2M | 7,188,888 | 3.04% | 2q | +43.8%+$103.0M |
| Driehaus Capital Management LLC | $322.0M | 6,845,276 | 1.87% | 3q | +15.8%+$43.9M |
| Jupiter Topco LLC | $264.0M | 5,615,645 | 0.11% | new | FIRST |
| Capital World Investors | $252.5M | 5,367,723 | 0.03% | new | NEW |
| FMR LLC | $223.6M | 4,752,921 | 0.01% | 2q | +162.6%+$138.5M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $218.8M | 4,652,032 | 0.02% | 3q | +6545.7%+$215.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $171.5M | 3,644,813 | 0.01% | 2q | +46.1%+$54.1M |
| STATE STREET CORP | $144.2M | 3,065,390 | 0.00% | 2q | +24.0%+$27.9M |
| Capital International Investors | $139.4M | 2,963,410 | 0.03% | new | NEW |
| Octagon Capital Advisors LP | $138.8M | 2,950,000 | 12.47% | 2q | +20.9%+$24.0M |
| WELLINGTON MANAGEMENT GROUP LLP | $138.8M | 2,949,734 | 0.02% | 2q | +126.1%+$77.4M |
| Deep Track Capital, LP | $129.4M | 2,750,000 | 1.88% | 2q | -8.3%-$11.8M |
| CITADEL ADVISORS LLC | $106.4M incl. $26.9M options CALL+PUT | 1,688,587 | 0.01% | 2q | +26.6%+$22.4M |
| Commodore Capital LP | $94.1M | 2,000,000 | 5.60% | 2q | HELD |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $89.3M incl. $87.4M options CALL+PUT | 40,954 | 0.01% | 2q | -49.7%-$88.3M |
| GOLDMAN SACHS GROUP INC | $84.7M | 1,800,852 | 0.01% | 2q | +7.5%+$5.9M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $77.5M | 1,648,426 | 0.00% | 2q | +88.9%+$36.5M |
| RA CAPITAL MANAGEMENT, L.P. | $70.6M | 1,500,000 | 0.61% | new | NEW |
| VANGUARD CAPITAL MANAGEMENT LLC | $69.9M | 1,486,454 | 0.00% | 2q | +35.5%+$18.3M |
| Siren, L.L.C. | $66.8M | 1,419,493 | 1.35% | 2q | +54.4%+$23.5M |
| MARSHALL WACE, LLP | $61.1M | 1,298,946 | 0.05% | 3q | +8.2%+$4.6M |
| NORTHERN TRUST CORP | $55.0M | 1,169,238 | 0.01% | 2q | +46.3%+$17.4M |
| AMERIPRISE FINANCIAL INC | $54.0M | 1,148,363 | 0.01% | 2q | +18.8%+$8.5M |
| Nuveen, LLC | $52.0M | 1,105,314 | 0.01% | 2q | +58.3%+$19.2M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $51.0M | 1,083,576 | 0.01% | 2q | +34.0%+$12.9M |
| Woodline Partners LP | $47.2M | 1,003,641 | 0.15% | 2q | +33.3%+$11.8M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $47.0M | 1,000,000 | 0.07% | 2q | -13.0%-$7.1M |
| Boxer Capital Management, LLC | $47.0M | 998,500 | 3.54% | 2q | +66.8%+$18.8M |
| TWO SIGMA INVESTMENTS, LP | $43.4M | 921,818 | 0.03% | 2q | -23.3%-$13.2M |
| Balyasny Asset Management L.P. | $42.2M | 897,658 | 0.05% | 2q | -29.6%-$17.7M |
| VANGUARD FIDUCIARY TRUST CO | $38.9M | 827,693 | 0.01% | 2q | +43.7%+$11.8M |
| Holocene Advisors, LP | $37.5M | 796,574 | 0.08% | 2q | -27.1%-$13.9M |
| AWM Investment Company, Inc. | $36.9M | 784,800 | 3.20% | 3q | -27.1%-$13.7M |
| Bank of New York Mellon Corp | $36.6M | 777,271 | 0.01% | 2q | +3.2%+$1.1M |
| Polar Capital Holdings Plc | $36.6M | 777,253 | 0.09% | new | NEW |
| JANE STREET GROUP, LLC | $35.4M CALL+PUT | options only | 0.00% | 2q | OPTIONS |
| ALLIANCEBERNSTEIN L.P. | $34.1M | 1,803,287 | 0.01% | 2q | +1866.4%+$32.3M |
| EVENTIDE ASSET MANAGEMENT, LLC | $33.4M | 710,000 | 0.45% | 2q | +3.5%+$1.1M |
| NEUBERGER BERMAN GROUP LLC | $32.3M | 687,539 | 0.02% | 2q | +415.5%+$26.1M |
| Qube Research & Technologies Ltd | $32.1M | 682,901 | 0.03% | 2q | +60.3%+$12.1M |
| Candriam S.C.A. | $28.9M | 614,425 | 0.13% | 2q | -52.5%-$31.9M |
| ArrowMark Colorado Holdings LLC | $26.5M | 564,069 | 1.10% | 2q | -64.6%-$48.5M |
| Catalio Capital Management, LP | $26.5M | 562,672 | 4.97% | 2q | -45.8%-$22.4M |
| Blackstone Inc. | $26.4M | 561,612 | 0.07% | 2q | +10.4%+$2.5M |
| Integral Health Asset Management, LLC | $25.9M | 550,000 | 1.02% | 2q | +37.5%+$7.1M |
| BAMCO INC /NY/ | $24.5M | 520,108 | 0.04% | new | NEW |
| UBS Group AG | $23.5M | 499,467 | 0.00% | 2q | +1.1%+$258.2K |
| FRANKLIN RESOURCES INC | $22.9M | 486,219 | 0.00% | new | NEW |
| Point72 Asset Management, L.P. | $22.8M | 483,980 | 0.03% | 2q | +175.8%+$14.5M |
| Ensign Peak Advisors, Inc | $21.9M | 466,106 | 0.04% | 3q | -14.8%-$3.8M |
| MORGAN STANLEY | $21.4M | 454,912 | 0.00% | 2q | +3.7%+$768.6K |
| GREAT POINT PARTNERS LLC | $20.0M | 425,000 | 3.78% | new | NEW |
| Caption Management, LLC | $19.6M incl. $17.5M options CALL | 45,000 | 0.09% | 2q | +33.3%+$4.9M |
| RTW INVESTMENTS, LP | $18.8M | 400,000 | 0.16% | 2q | +33.3%+$4.7M |
| Cormorant Asset Management, LP | $18.8M | 400,000 | 0.96% | new | NEW |
| SILVERARC CAPITAL MANAGEMENT, LLC | $18.8M | 400,000 | 1.96% | new | NEW |
| Ally Bridge Group (NY) LLC | $18.8M CALL | options only | 16.64% | new | OPTIONS |
| ASSETMARK, INC | $18.7M | 396,542 | 0.03% | new | NEW |
| GROUP ONE TRADING LLC | $18.0M incl. $15.0M options CALL+PUT | 63,943 | 0.03% | 2q | -27.2%-$6.7M |
| MILLENNIUM MANAGEMENT LLC | $17.7M incl. $5.2M options PUT | 266,076 | 0.01% | 2q | -68.6%-$38.6M |
| ORBIMED ADVISORS LLC | $17.2M | 365,400 | 0.32% | 2q | -54.6%-$20.6M |
| Duquesne Family Office LLC | $16.8M | 356,600 | 0.32% | new | NEW |
| D. E. Shaw & Co., Inc. | $14.8M | 315,410 | 0.01% | 2q | +16.1%+$2.1M |
| SILVERBACK ASSET MANAGEMENT LLC | $13.8M CALL | options only | 1.50% | 2q | OPTIONS |
| Tetragon Partners GP Ltd | $13.5M | 286,990 | 2.13% | 2q | +43.5%+$4.1M |
| JPMORGAN CHASE & CO | $12.4M | 265,955 | 0.00% | 2q | +0.5%+$65.6K |
| Sofinnova Investments, Inc. | $12.0M | 255,903 | 0.62% | 2q | -25.6%-$4.2M |
| PFM Health Sciences, LP | $11.7M | 249,020 | 1.01% | 2q | +21.3%+$2.1M |
| HighVista Strategies LLC | $11.4M | 242,884 | 2.60% | 2q | +30.7%+$2.7M |
| Trexquant Investment LP | $11.0M | 233,199 | 0.06% | new | NEW |
| SEVEN GRAND MANAGERS, LLC | $10.6M | 225,000 | 0.43% | 2q | HELD |
| Swiss National Bank | $10.4M | 221,200 | 0.01% | 2q | +39.6%+$3.0M |
| Eversept Partners, LP | $10.2M | 217,185 | 0.53% | 2q | +35.1%+$2.7M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $9.9M | 211,183 | 0.00% | 2q | +8651.9%+$9.8M |
| TD Asset Management Inc | $9.9M | 209,460 | 0.01% | new | NEW |
| ROYCE & ASSOCIATES LP | $9.8M | 208,551 | 0.08% | 2q | -10.9%-$1.2M |
| SEB Asset Management AB | $9.8M | 208,254 | 0.04% | new | NEW |
| SIMPLEX TRADING, LLC | $8.9M incl. $6.7M options CALL+PUT | 47,651 | 0.01% | 2q | +15.8%+$1.2M |
| SUPERSTRING CAPITAL MANAGEMENT LP | $8.9M | 188,282 | 5.59% | 2q | -46.4%-$7.7M |
| EMERALD ADVISERS, LLC | $8.4M | 178,751 | 0.20% | new | NEW |
| Aberdeen Group plc | $8.2M | 175,000 | 0.01% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $7.7M | 164,575 | 0.00% | 2q | +3.9%+$293.1K |
| Tri Locum Partners LP | $7.7M | 162,996 | 0.94% | 2q | -55.9%-$9.7M |
| RHUMBLINE ADVISERS | $7.4M | 158,096 | 0.01% | 2q | +31.8%+$1.8M |
| Brevan Howard Capital Management LP | $7.4M | 156,812 | 0.05% | 2q | -25.9%-$2.6M |
| Russell Investments Group, Ltd. | $7.2M | 153,477 | 0.01% | 2q | +28.5%+$1.6M |
| LMR Partners LLP | $7.1M | 150,200 | 0.03% | new | NEW |
| Seven Fleet Capital Management LP | $7.0M | 148,647 | 1.15% | 2q | +48.8%+$2.3M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $6.9M | 146,368 | 0.01% | 2q | +454.3%+$5.6M |
| Rock Springs Capital Management LP | $6.7M | 143,187 | 0.33% | new | NEW |
| DEUTSCHE BANK AG\ | $6.7M | 142,947 | 0.00% | 2q | -65.3%-$12.6M |
| SummitTX Capital, L.P. | $6.7M | 142,489 | 0.17% | new | NEW |
| STEMPOINT CAPITAL LP | $6.5M | 137,124 | 1.11% | 2q | -78.9%-$24.2M |
| AQR CAPITAL MANAGEMENT LLC | $6.3M | 134,152 | 0.00% | 2q | +135.0%+$3.6M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $6.0M | 128,346 | 0.01% | new | NEW |
| BIT Capital GmbH | $6.0M | 128,131 | 0.18% | 2q | -53.8%-$7.0M |
| FRED ALGER MANAGEMENT, LLC | $5.9M | 125,256 | 0.02% | 2q | +35.9%+$1.6M |
| WELLS FARGO & COMPANY/MN | $5.7M | 122,033 | 0.00% | 2q | +205.3%+$3.9M |
| Atika Capital Management LLC | $5.7M | 122,000 | 0.38% | new | NEW |
Showing the largest 100 of 371 reported holders. The count of 370 above leaves out 1 position whose reported value failed our price check; it is listed here as filed.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-06-25 | Barrow Robert | Chief Executive Officer | Sold | 29,208 | $1.3M |
| 2026-09-25 | Barrow Robert | Chief Executive Officer | Sold | 31,550 | $1.2M |
| 2026-09-03 | Barrow Robert | Chief Executive Officer | Sold | 19,023 | $721.7K |
| 2026-06-25 | Sullivan Mark | Chief Legal Officer | Sold | 13,008 | $585.8K |
| 2026-09-25 | Sullivan Mark | Chief Legal Officer | Sold | 14,051 | $513.8K |
| 2026-06-25 | Karlin Daniel | Chief Medical Officer | Sold | 10,035 | $451.9K |
| 2026-09-25 | Karlin Daniel | Chief Medical Officer | Sold | 10,853 | $396.9K |
| 2026-06-25 | Roberts Brandi | Chief Financial Officer | Sold | 3,013 | $135.7K |
| 2026-06-25 | Wiley Matthew T. | Chief Commercial Officer | Sold | 2,867 | $129.1K |
| 2026-09-25 | Roberts Brandi | Chief Financial Officer | Sold | 3,377 | $123.5K |
| 2026-09-25 | Wiley Matthew T. | Chief Commercial Officer | Sold | 3,097 | $113.3K |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 70 | $39.3M | 1,035,889 | 15 | 19 | 11 | 0.0% |
| Q2 2026 | 370 | $5.6B | 114,855,731 | 151 | 113 | 63 | 4.4% |
| Q1 2026 | 250 | $1.5B | 78,419,086 | 240 | 2 | 4 | 2.7% |
| Q4 2025 | 8 | $150.7M | 11,252,538 | 7 | 0 | 0 | 0.0% |