DaveManuel.com · Institutional Ownership · Who Owns It
EDGEWISE THERAPEUTICS INC (EWTX)
Institutional ownership reported to the SEC as of Q2 2026, across 23 quarters.
229
Reporting holders
$4.8B
Reported value
109.8%
Of shares outstanding
0.3%
Calls
0.2%
Puts
+13
Holder change
Institutions report 119,261,961 shares against 108,604,129 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $630.5M | 15,518,492 | 11.68% | 22q | HELD |
| Paradigm Biocapital Advisors LP | $415.1M | 10,215,455 | 7.77% | 10q | +38.7%+$115.8M |
| RA CAPITAL MANAGEMENT, L.P. | $341.0M | 8,392,730 | 2.96% | 10q | -19.5%-$82.7M |
| BlackRock, Inc. | $268.4M | 6,606,336 | 0.00% | 8q | +2.1%+$5.4M |
| Jupiter Topco LLC | $246.9M | 6,075,331 | 0.10% | new | FIRST |
| FMR LLC | $223.0M | 5,489,135 | 0.01% | 22q | +439.7%+$181.7M |
| NOVO HOLDINGS A/S | $217.4M | 5,350,000 | 12.62% | 9q | HELD |
| Driehaus Capital Management LLC | $192.1M | 4,728,623 | 1.11% | 11q | +5.6%+$10.2M |
| PERCEPTIVE ADVISORS LLC | $177.7M | 4,373,974 | 2.67% | 11q | -1.1%-$2.0M |
| VANGUARD CAPITAL MANAGEMENT LLC | $156.9M | 3,860,670 | 0.00% | 2q | +1.9%+$2.9M |
| BAKER BROS. ADVISORS LP | $150.4M | 3,701,719 | 0.75% | 22q | -43.7%-$116.8M |
| Siren, L.L.C. | $129.4M | 3,184,629 | 2.62% | 8q | -28.1%-$50.6M |
| Cormorant Asset Management, LP | $102.0M | 2,510,000 | 5.23% | 22q | -23.0%-$30.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $88.3M | 2,174,051 | 0.00% | 21q | +21.5%+$15.6M |
| Integral Health Asset Management, LLC | $81.3M | 2,000,000 | 3.21% | 8q | +25.0%+$16.3M |
| BRAIDWELL LP | $81.1M | 1,996,965 | 3.00% | 8q | -14.9%-$14.2M |
| MORGAN STANLEY | $79.2M | 1,948,597 | 0.00% | 21q | -13.2%-$12.1M |
| STATE STREET CORP | $74.3M | 1,827,927 | 0.00% | 21q | +6.5%+$4.5M |
| ALLIANCEBERNSTEIN L.P. | $66.7M | 2,119,024 | 0.02% | 16q | +23.0%+$12.5M |
| MPM BIOIMPACT LLC | $65.9M | 1,620,780 | 4.02% | 10q | -2.4%-$1.6M |
| BANK OF AMERICA CORP /DE/ | $63.3M | 1,558,260 | 0.00% | 20q | +17.4%+$9.4M |
| Qube Research & Technologies Ltd | $50.9M | 1,252,507 | 0.05% | 11q | +51.7%+$17.3M |
| DIMENSIONAL FUND ADVISORS LP | $46.3M | 1,139,726 | 0.01% | 16q | -6.6%-$3.3M |
| AMERICAN CENTURY COMPANIES INC | $45.8M | 1,127,078 | 0.02% | 22q | -1.8%-$816.6K |
| First Light Asset Management, LLC | $44.5M | 1,095,171 | 2.70% | 7q | +9.3%+$3.8M |
| VICTORY CAPITAL MANAGEMENT INC | $36.7M | 902,870 | 0.02% | 5q | +14.4%+$4.6M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $33.2M | 816,518 | 0.00% | 18q | +1076.1%+$30.4M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $32.0M | 786,456 | 0.00% | 2q | +41.1%+$9.3M |
| NORTHERN TRUST CORP | $27.3M | 671,270 | 0.00% | 21q | +16.4%+$3.8M |
| Aberdeen Group plc | $26.3M | 647,926 | 0.04% | 8q | -21.6%-$7.2M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $25.2M | 620,532 | 0.00% | 21q | +4.1%+$984.1K |
| Tyro Capital Management LLC | $24.9M | 612,965 | 5.59% | new | NEW |
| GOLDMAN SACHS GROUP INC | $24.4M | 599,469 | 0.00% | 19q | -4.8%-$1.2M |
| Parkman Healthcare Partners LLC | $23.4M | 577,036 | 2.40% | 16q | +78.7%+$10.3M |
| Artisan Partners Limited Partnership | $23.4M | 574,925 | 0.04% | 8q | -12.8%-$3.4M |
| VANGUARD FIDUCIARY TRUST CO | $22.3M | 548,285 | 0.00% | 2q | +5.1%+$1.1M |
| CITADEL ADVISORS LLC | $21.6M incl. $2.5M options CALL+PUT | 469,707 | 0.00% | 22q | +9.5%+$1.9M |
| NORGES BANK | $20.7M | 510,140 | 0.00% | 6q | -32.1%-$9.8M |
| Opaleye Management Inc. | $20.3M | 500,000 | 1.84% | 18q | HELD |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $18.8M | 462,000 | 0.03% | new | NEW |
| Soleus Capital Management, L.P. | $18.3M | 450,889 | 0.63% | 3q | -68.9%-$40.6M |
| Nuveen, LLC | $16.8M | 414,706 | 0.00% | 6q | +23.5%+$3.2M |
| Sofinnova Investments, Inc. | $15.5M | 380,923 | 0.80% | 9q | -1.4%-$226.5K |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $13.6M | 334,014 | 0.02% | 3q | -17.4%-$2.9M |
| RAYMOND JAMES FINANCIAL INC | $12.9M | 317,565 | 0.00% | 5q | +1513.8%+$12.1M |
| Squadron Capital Management LLC | $11.8M | 290,000 | 3.66% | 3q | -17.1%-$2.4M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $11.5M | 283,333 | 0.02% | 7q | HELD |
| DIADEMA PARTNERS LP | $11.1M | 272,214 | 1.40% | 3q | HELD |
| PRUDENTIAL FINANCIAL INC | $10.6M | 260,725 | 0.01% | 2q | +2358.5%+$10.2M |
| KENNEDY CAPITAL MANAGEMENT LLC | $10.4M | 256,608 | 0.18% | 11q | -2.9%-$308.6K |
| Schonfeld Strategic Advisors LLC | $10.4M | 255,202 | 0.04% | 14q | +157.6%+$6.3M |
| DEUTSCHE BANK AG\ | $10.0M | 244,995 | 0.00% | 21q | +10.4%+$939.7K |
| DAFNA Capital Management LLC | $9.2M | 226,819 | 1.76% | 18q | +102.1%+$4.7M |
| Woodline Partners LP | $9.1M | 224,290 | 0.03% | 22q | HELD |
| Bank of New York Mellon Corp | $8.6M | 212,347 | 0.00% | 21q | +10.3%+$809.1K |
| JPMORGAN CHASE & CO | $8.5M | 203,151 | 0.00% | 21q | +37.7%+$2.3M |
| PEREGRINE CAPITAL MANAGEMENT LLC | $8.1M | 198,570 | 0.26% | 2q | -4.8%-$410.4K |
| SEB Asset Management AB | $7.9M | 194,063 | 0.03% | 2q | -6.0%-$505.8K |
| Granahan Investment Management, LLC | $7.9M | 193,778 | 0.28% | 14q | -3.5%-$287.1K |
| NEUBERGER BERMAN GROUP LLC | $7.8M | 191,195 | 0.01% | 6q | +13.3%+$914.9K |
| BARCLAYS PLC | $7.7M | 190,205 | 0.00% | 18q | +7.3%+$526.6K |
| D. E. Shaw & Co., Inc. | $7.7M | 189,115 | 0.00% | 11q | +80.3%+$3.4M |
| UBS Group AG | $7.1M | 174,967 | 0.00% | 10q | -86.7%-$46.2M |
| Caption Management, LLC | $6.5M CALL | options only | 0.03% | 3q | OPTIONS |
| ADAR1 Capital Management, LLC | $5.8M | 143,199 | 0.27% | 6q | +58.1%+$2.1M |
| KVP Capital Advisors, LP | $5.4M | 133,000 | 3.97% | 3q | HELD |
| Point72 Asset Management, L.P. | $5.4M incl. $593.2K options PUT | 117,262 | 0.01% | 2q | HELD |
| Invesco Ltd. | $4.9M | 120,932 | 0.00% | 19q | -12.6%-$709.7K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4.8M | 118,209 | 0.00% | 11q | +3.0%+$141.8K |
| Quantum Private Wealth, LLC | $4.6M | 113,380 | 1.18% | 19q | -2.8%-$131.8K |
| ALPS ADVISORS INC | $4.4M | 108,795 | 0.02% | 15q | +24.6%+$872.3K |
| Moody Aldrich Partners LLC | $4.3M | 104,952 | 0.77% | 8q | -8.1%-$373.3K |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | $4.1M PUT | options only | 0.42% | new | OPTIONS |
| Artia Global Partners LP | $4.0M | 98,800 | 0.74% | 2q | +50.8%+$1.4M |
| Swiss National Bank | $3.9M | 96,800 | 0.00% | 11q | -6.8%-$288.5K |
| VOYA INVESTMENT MANAGEMENT LLC | $3.8M | 94,671 | 0.00% | 19q | +141.8%+$2.3M |
| HSBC HOLDINGS PLC | $3.7M | 91,638 | 0.00% | new | NEW |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3.7M incl. $3.5M options CALL+PUT | 5,692 | 0.00% | 11q | -78.7%-$13.7M |
| HighVista Strategies LLC | $3.7M | 90,996 | 0.84% | 8q | -1.0%-$38.0K |
| RHUMBLINE ADVISERS | $3.7M | 90,232 | 0.00% | 19q | +8.0%+$271.9K |
| HRT FINANCIAL LP | $3.5M incl. $3.5M options OPT | 85,000 | 0.01% | new | NEW |
| Ally Bridge Group (NY) LLC | $3.4M | 83,300 | 2.99% | 3q | -48.3%-$3.2M |
| BOOTHBAY FUND MANAGEMENT, LLC | $3.4M | 82,734 | 0.04% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $3.3M | 80,197 | 0.00% | 21q | -9.8%-$355.1K |
| WELLS FARGO & COMPANY/MN | $3.2M | 78,898 | 0.00% | 14q | +212.5%+$2.2M |
| Russell Investments Group, Ltd. | $3.2M | 77,733 | 0.00% | 7q | +1082.4%+$2.9M |
| Centiva Capital, LP | $3.1M incl. $3.0M options CALL | 1,217 | 0.03% | 3q | +125.8%+$1.7M |
| Jefferies Financial Group Inc. | $2.9M | 71,389 | 0.02% | new | NEW |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2.9M | 71,306 | 0.00% | 21q | -2.9%-$85.9K |
| Persistent Asset Partners Ltd | $2.8M | 69,441 | 0.84% | 3q | +590.7%+$2.4M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $2.6M | 64,918 | 0.00% | 2q | -3.7%-$101.2K |
| GROUP ONE TRADING LLC | $2.6M incl. $2.4M options CALL+PUT | 4,477 | 0.00% | 9q | HELD |
| DekaBank Deutsche Girozentrale | $2.5M | 80,000 | 0.00% | 19q | HELD |
| CITIGROUP INC | $2.4M | 59,563 | 0.00% | 21q | +221.7%+$1.7M |
| TUDOR INVESTMENT CORP ET AL | $2.3M | 56,934 | 0.00% | 9q | +90.5%+$1.1M |
| STATE OF WISCONSIN INVESTMENT BOARD | $2.3M | 56,910 | 0.00% | 10q | +73.0%+$975.7K |
| HighMark Wealth Management LLC | $2.2M | 53,179 | 0.72% | 7q | HELD |
| TWO SIGMA INVESTMENTS, LP | $2.0M | 49,548 | 0.00% | 4q | -2.6%-$52.8K |
| SEI INVESTMENTS CO | $1.9M | 47,543 | 0.00% | 8q | -3.1%-$62.5K |
| ALGERT GLOBAL LLC | $1.9M | 47,240 | 0.02% | 2q | +45.3%+$598.1K |
Showing the largest 100 of 230 reported holders. The count of 229 above leaves out 1 position whose reported value failed our price check; it is listed here as filed.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-07-01 | Russell Alan J | Chief Scientific Officer | Sold | 200,000 | $7.9M ×2 |
| 2026-08-12 | KOCH KEVIN | President and CEO | Sold | 17,971 | $785.0K ×3 |
| 2026-08-12 | Donovan Joanne M. | CMO | Sold | 6,522 | $286.0K ×4 |
| 2026-08-12 | Russell Alan J | Chief Scientific Officer | Sold | 5,901 | $258.0K ×3 |
| 2026-08-12 | Derakhshan Behrad | Chief Business Officer | Sold | 5,100 | $223.4K ×4 |
| 2026-08-12 | MOORE JOHN R | General Counsel | Sold | 5,016 | $219.8K ×4 |
| 2026-08-13 | Donovan Joanne M. | CMO | Sold | 2,919 | $126.7K |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 33 | $43.3M | 1,066,933 | 6 | 11 | 7 | 0.0% |
| Q2 2026 | 229 | $4.8B | 119,261,961 | 40 | 81 | 74 | 0.6% |
| Q1 2026 | 216 | $3.8B | 118,806,020 | 34 | 62 | 63 | 0.8% |
| Q4 2025 | 203 | $3.0B | 121,825,103 | 39 | 67 | 55 | 0.8% |
| Q3 2025 | 176 | $1.8B | 112,032,755 | 19 | 56 | 62 | 0.3% |
| Q2 2025 | 179 | $1.6B | 118,745,548 | 29 | 85 | 39 | 0.1% |
| Q1 2025 | 200 | $2.4B | 105,730,359 | 34 | 63 | 60 | 3.9% |
| Q4 2024 | 206 | $2.7B | 98,998,462 | 37 | 66 | 64 | 1.2% |
| Q3 2024 | 181 | $2.8B | 101,593,919 | 56 | 54 | 44 | 2.6% |
| Q2 2024 | 139 | $1.8B | 101,709,436 | 33 | 57 | 28 | 0.1% |
| Q1 2024 | 128 | $1.7B | 92,425,836 | 30 | 58 | 28 | 0.0% |
| Q4 2023 | 118 | $874.7M | 79,913,745 | 35 | 42 | 16 | 0.0% |
| Q3 2023 | 85 | $392.2M | 68,438,550 | 9 | 40 | 16 | 0.0% |
| Q2 2023 | 94 | $539.0M | 69,494,971 | 12 | 40 | 22 | 0.0% |
| Q1 2023 | 85 | $496.1M | 74,396,286 | 10 | 30 | 22 | 0.0% |
| Q4 2022 | 90 | $594.2M | 66,453,574 | 11 | 40 | 20 | 0.0% |
| Q3 2022 | 90 | $674.7M | 68,564,956 | 23 | 36 | 19 | 0.0% |
| Q2 2022 | 74 | $426.7M | 53,605,654 | 15 | 18 | 23 | 0.0% |
| Q1 2022 | 68 | $547.4M | 56,424,956 | 17 | 21 | 16 | 0.0% |
| Q4 2021 | 56 | $939.1M | 61,438,625 | 15 | 25 | 3 | 0.0% |
| Q3 2021 | 47 | $795.8M | 48,038,152 | 4 | 16 | 11 | 0.0% |
| Q2 2021 | 46 | $1.0B | 47,877,175 | 23 | 9 | 5 | 0.0% |
| Q1 2021 | 31 | $1.5B | 45,681,359 | 31 | 0 | 0 | 0.0% |