DaveManuel.com · Institutional Ownership · Who Owns It
KRYSTAL BIOTECH INC (KRYS)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
433
Reporting holders
$11.3B
Reported value
102.4%
Of shares outstanding
0.8%
Calls
1.0%
Puts
+62
Holder change
Institutions report 30,307,351 shares against 29,598,836 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $1.6B | 4,418,197 | 0.07% | 31q | +1.0%+$16.4M |
| BlackRock, Inc. | $1.6B | 4,181,432 | 0.02% | 8q | +6.1%+$89.6M |
| Avoro Capital Advisors LLC | $1.1B | 2,888,888 | 9.64% | 19q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $585.3M | 1,574,905 | 0.03% | 2q | +8.1%+$43.9M |
| STATE STREET CORP | $502.2M | 1,351,158 | 0.01% | 30q | +2.8%+$13.6M |
| VANGUARD CAPITAL MANAGEMENT LLC | $461.1M | 1,240,567 | 0.01% | 2q | +6.5%+$28.0M |
| Soleus Capital Management, L.P. | $349.1M | 939,254 | 12.03% | 23q | -18.5%-$79.5M |
| Capital World Investors | $289.1M | 777,843 | 0.03% | 10q | -5.7%-$17.4M |
| GEODE CAPITAL MANAGEMENT, LLC | $259.8M | 698,993 | 0.01% | 31q | +8.5%+$20.5M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $255.5M | 687,400 | 0.03% | 22q | +41.7%+$75.2M |
| Hood River Capital Management LLC | $246.6M | 663,375 | 1.79% | 25q | +7.1%+$16.3M |
| Redmile Group, LLC | $234.9M | 632,005 | 15.77% | 31q | -6.2%-$15.4M |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $211.9M | 570,153 | 0.64% | 5q | +40.0%+$60.6M |
| Frazier Life Sciences Management, L.P. | $178.9M | 481,307 | 3.90% | 18q | HELD |
| DIMENSIONAL FUND ADVISORS LP | $176.9M | 476,038 | 0.03% | 25q | +1.5%+$2.6M |
| FIRST TRUST ADVISORS LP | $120.8M | 324,900 | 0.07% | 8q | -7.3%-$9.5M |
| Invesco Ltd. | $120.7M | 324,755 | 0.01% | 22q | +29.2%+$27.3M |
| GOLDMAN SACHS GROUP INC | $111.1M | 298,841 | 0.01% | 27q | +39.0%+$31.2M |
| NORTHERN TRUST CORP | $105.5M | 283,784 | 0.01% | 31q | +12.4%+$11.6M |
| FRANKLIN RESOURCES INC | $97.3M | 261,917 | 0.02% | 18q | +46.1%+$30.7M |
| NORGES BANK | $96.3M | 259,030 | 0.01% | 14q | -9.0%-$9.5M |
| Jupiter Topco LLC | $95.4M | 256,665 | 0.04% | new | FIRST |
| BANK OF AMERICA CORP /DE/ | $95.3M | 256,431 | 0.01% | 31q | -1.6%-$1.6M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $94.7M | 254,828 | 0.01% | 29q | +5.3%+$4.8M |
| MORGAN STANLEY | $87.5M | 235,491 | 0.00% | 33q | +12.6%+$9.8M |
| VESTOR CAPITAL, LLC | $78.2M | 700,914 | 4.91% | 3q | +350357.0%+$78.2M |
| VANGUARD FIDUCIARY TRUST CO | $70.4M | 189,528 | 0.02% | 2q | +5.8%+$3.9M |
| Nantahala Capital Management, LLC | $63.2M PUT | options only | 1.05% | new | OPTIONS |
| PRINCIPAL FINANCIAL GROUP INC | $63.0M | 169,550 | 0.03% | 17q | +4.6%+$2.8M |
| Bank of New York Mellon Corp | $60.8M | 163,610 | 0.01% | 31q | +9.6%+$5.3M |
| UBS Group AG | $60.2M incl. $5.1M options CALL+PUT | 148,316 | 0.01% | 11q | +3.3%+$1.9M |
| RAYMOND JAMES FINANCIAL INC | $59.0M | 158,675 | 0.02% | 7q | +1.7%+$970.4K |
| Woodline Partners LP | $56.0M | 150,616 | 0.17% | 13q | HELD |
| Nuveen, LLC | $54.5M | 146,520 | 0.01% | 6q | +2.2%+$1.2M |
| Caption Management, LLC | $48.5M CALL+PUT | options only | 0.23% | 13q | OPTIONS |
| BRAIDWELL LP | $47.9M | 128,975 | 1.77% | 15q | -29.3%-$19.9M |
| VOYA INVESTMENT MANAGEMENT LLC | $46.3M | 124,442 | 0.04% | 28q | +14.8%+$6.0M |
| TimesSquare Capital Management, LLC | $41.5M | 111,545 | 0.61% | 12q | -0.7%-$296.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $40.8M incl. $40.1M options CALL+PUT | 1,899 | 0.00% | 26q | -79.0%-$153.5M |
| Pictet Asset Management Holding SA | $40.1M | 107,798 | 0.04% | 12q | -2.6%-$1.1M |
| Public Sector Pension Investment Board | $39.2M | 105,515 | 0.10% | 9q | +14.3%+$4.9M |
| 1832 Asset Management L.P. | $36.9M | 99,300 | 0.02% | 3q | +133.1%+$21.1M |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $36.7M | 98,707 | 0.12% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $34.3M | 92,234 | 0.01% | 29q | -0.9%-$296.2K |
| Handelsbanken Fonder AB | $33.6M | 90,407 | 0.10% | 25q | -1.1%-$369.1K |
| JPMORGAN CHASE & CO | $33.5M | 87,342 | 0.00% | 31q | -11.9%-$4.5M |
| ORBIMED ADVISORS LLC | $30.9M | 83,200 | 0.57% | 11q | +20.4%+$5.2M |
| S SQUARED TECHNOLOGY, LLC | $28.8M | 77,545 | 8.94% | 31q | -10.1%-$3.2M |
| Bellevue Group AG | $28.8M | 77,530 | 0.61% | 19q | -83.9%-$150.2M |
| Biondo Investment Advisors, LLC | $26.4M | 70,945 | 3.23% | 5q | -1.5%-$408.8K |
| SEGALL BRYANT & HAMILL, LLC | $24.2M | 65,211 | 0.29% | 9q | -18.0%-$5.3M |
| RHUMBLINE ADVISERS | $22.8M | 61,236 | 0.02% | 29q | -10.1%-$2.6M |
| RENAISSANCE TECHNOLOGIES LLC | $22.2M | 59,680 | 0.03% | 3q | +521.7%+$18.6M |
| Legal & General Group Plc | $21.8M | 58,580 | 0.00% | 29q | -0.8%-$174.7K |
| C WorldWide Group Holding A/S | $21.5M | 57,809 | 0.52% | 26q | -14.7%-$3.7M |
| CITIGROUP INC | $20.8M | 56,016 | 0.01% | 31q | +79.7%+$9.2M |
| Bridgewater Associates, LP | $20.3M | 54,489 | 0.08% | 4q | +17.5%+$3.0M |
| SEI INVESTMENTS CO | $20.1M | 54,040 | 0.02% | 29q | +16.0%+$2.8M |
| Russell Investments Group, Ltd. | $19.6M | 52,621 | 0.02% | 14q | +100.8%+$9.8M |
| Allspring Global Investments Holdings, LLC | $19.5M | 52,407 | 0.03% | 19q | +2017.5%+$18.6M |
| NEUBERGER BERMAN GROUP LLC | $19.3M | 51,876 | 0.01% | 3q | +56.8%+$7.0M |
| AMERIPRISE FINANCIAL INC | $18.1M | 48,790 | 0.00% | 12q | -2.1%-$389.1K |
| Palisades Investment Partners, LLC | $17.8M | 47,801 | 5.05% | 9q | +5.3%+$890.5K |
| ACT CAPITAL MANAGEMENT, LLC | $16.7M | 45,000 | 10.93% | 9q | -25.6%-$5.8M |
| VICTORY CAPITAL MANAGEMENT INC | $16.7M | 44,935 | 0.01% | 17q | +10.4%+$1.6M |
| FEDERATED HERMES, INC. | $16.3M | 43,848 | 0.02% | 8q | +23.5%+$3.1M |
| CITADEL ADVISORS LLC | $16.0M incl. $15.0M options CALL+PUT | 2,725 | 0.00% | 31q | HELD |
| Swiss National Bank | $15.4M | 41,360 | 0.01% | 29q | -3.8%-$609.5K |
| GILDER GAGNON HOWE & CO LLC | $15.0M | 40,296 | 0.15% | 2q | HELD |
| CONGRESS ASSET MANAGEMENT CO | $14.9M | 40,134 | 0.09% | new | NEW |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $14.4M | 38,697 | 0.00% | 27q | +4.8%+$654.1K |
| SEB Asset Management AB | $14.0M | 37,731 | 0.05% | 2q | -18.6%-$3.2M |
| WELLINGTON MANAGEMENT GROUP LLP | $13.7M | 36,936 | 0.00% | 10q | +261.2%+$9.9M |
| Life Cycle Investment Partners Ltd | $13.1M | 35,124 | 0.06% | new | NEW |
| WELLS FARGO & COMPANY/MN | $12.8M | 34,502 | 0.00% | 31q | +130.2%+$7.3M |
| NEW YORK STATE COMMON RETIREMENT FUND | $12.6M | 34,033 | 0.02% | 31q | +8.6%+$1.0M |
| Granite Investment Partners, LLC | $12.2M | 32,837 | 0.63% | 3q | +35.2%+$3.2M |
| PRUDENTIAL FINANCIAL INC | $12.1M | 32,662 | 0.01% | 13q | +10.2%+$1.1M |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $11.9M | 31,998 | 0.12% | 27q | -10.8%-$1.4M |
| DEUTSCHE BANK AG\ | $11.8M | 31,836 | 0.00% | 30q | +28.2%+$2.6M |
| Corient Private Wealth LP | $11.4M | 30,558 | 0.02% | 10q | +767.4%+$10.0M |
| JANE STREET GROUP, LLC | $10.6M incl. $10.2M options CALL+PUT | 956 | 0.00% | 14q | HELD |
| Fisher Asset Management, LLC | $10.3M | 27,676 | 0.00% | 3q | HELD |
| D. E. Shaw & Co., Inc. | $10.2M CALL+PUT | options only | 0.00% | 18q | OPTIONS |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $9.6M | 25,867 | 0.01% | 29q | -28.3%-$3.8M |
| Aberdeen Group plc | $9.3M | 25,141 | 0.01% | 10q | -16.6%-$1.9M |
| Atle Fund Management AB | $8.9M | 24,019 | 2.40% | 12q | -36.1%-$5.0M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $8.8M | 23,692 | 0.01% | 29q | -9.5%-$926.9K |
| ALLIANCEBERNSTEIN L.P. | $8.8M | 34,039 | 0.00% | 29q | +6.6%+$545.1K |
| TD Asset Management Inc | $8.4M | 22,712 | 0.01% | 13q | -47.6%-$7.7M |
| Elmind Capital, LP | $8.2M | 22,000 | 2.05% | 3q | HELD |
| CANADA LIFE ASSURANCE Co | $8.1M | 21,711 | 0.01% | 29q | +1.4%+$110.6K |
| VANGUARD ASSET MANAGEMENT, Ltd | $8.0M | 21,390 | 0.01% | 2q | +3.8%+$291.4K |
| Creative Planning | $7.6M | 20,318 | 0.00% | 10q | +27.5%+$1.6M |
| BESSEMER GROUP INC | $7.5M | 20,285 | 0.01% | 9q | HELD |
| Pinnacle Financial Partners, Inc. | $7.5M | 20,243 | 0.05% | 3q | HELD |
| Tetragon Partners GP Ltd | $7.3M | 19,668 | 1.15% | 4q | HELD |
| Lisanti Capital Growth, LLC | $7.1M | 19,050 | 1.56% | 2q | +2.9%+$198.8K |
| GW&K Investment Management, LLC | $6.8M | 18,295 | 0.05% | 10q | -4.9%-$353.1K |
| Thrivent Financial for Lutherans | $6.4M | 17,229 | 0.01% | 9q | HELD |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-10-30 | 13G/A | Vanguard Portfolio Management | 4.4% |
| 2026-10-27 | 13G/A | BlackRock, Inc. | 11.6% |
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-08-14 | ROSSI DINO A | Director | Sold | 25,000 | $8.2M ×8 |
| 2026-06-25 | Thomas John Charles | EVP, General Counsel | Sold | 1,000 | $347.3K |
| 2026-05-26 | Thomas John Charles | EVP, General Counsel | Sold | 642 | $193.9K |
Ten percent owners and entities
Usually an institution that crossed a reporting threshold, or a company taking a strategic stake, rather than an individual with a view.
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-09-04 | Krishnan Krish S | President and CEO | Sold | 25,000 | $9.0M ×13 |
| 2026-09-04 | Krishnan Suma | President, R&D | Sold | 25,000 | $9.0M ×13 |
| 2026-06-04 | Krishnan Krish S | President and CEO | Sold | 25,000 | $7.7M ×11 |
| 2026-06-04 | Krishnan Suma | President, R&D | Sold | 25,000 | $7.7M ×11 |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 107 | $108.3M | 325,831 | 23 | 44 | 20 | 0.0% |
| Q2 2026 | 433 | $11.3B | 30,307,351 | 91 | 175 | 110 | 1.8% |
| Q1 2026 | 371 | $7.4B | 28,376,530 | 69 | 129 | 101 | 1.5% |
| Q4 2025 | 337 | $7.1B | 28,460,602 | 61 | 106 | 100 | 1.1% |
| Q3 2025 | 287 | $5.1B | 28,160,190 | 44 | 101 | 82 | 3.1% |
| Q2 2025 | 280 | $3.9B | 27,653,337 | 44 | 94 | 96 | 3.3% |
| Q1 2025 | 305 | $5.1B | 27,672,121 | 63 | 86 | 108 | 1.4% |
| Q4 2024 | 272 | $4.5B | 27,775,625 | 27 | 89 | 93 | 2.2% |
| Q3 2024 | 288 | $5.3B | 28,409,155 | 52 | 100 | 89 | 2.9% |
| Q2 2024 | 252 | $5.4B | 29,085,914 | 51 | 96 | 71 | 1.8% |
| Q1 2024 | 244 | $4.9B | 26,345,062 | 70 | 61 | 80 | 5.1% |
| Q4 2023 | 199 | $3.3B | 25,570,037 | 21 | 71 | 58 | 4.7% |
| Q3 2023 | 191 | $2.9B | 24,469,296 | 18 | 82 | 51 | 2.1% |
| Q2 2023 | 190 | $2.9B | 23,898,601 | 44 | 56 | 63 | 1.6% |
| Q1 2023 | 164 | $2.0B | 24,139,987 | 22 | 53 | 51 | 1.1% |
| Q4 2022 | 157 | $1.8B | 22,176,588 | 19 | 55 | 49 | 1.5% |
| Q3 2022 | 145 | $1.9B | 27,424,784 | 21 | 50 | 39 | 0.8% |
| Q2 2022 | 132 | $1.8B | 27,423,245 | 19 | 40 | 49 | 0.7% |
| Q1 2022 | 129 | $1.8B | 27,212,071 | 21 | 47 | 43 | 0.5% |
| Q4 2021 | 136 | $1.7B | 24,072,220 | 33 | 53 | 21 | 2.9% |
| Q3 2021 | 120 | $1.2B | 21,054,413 | 15 | 44 | 35 | 5.0% |
| Q2 2021 | 116 | $1.4B | 21,076,866 | 17 | 50 | 28 | 0.9% |
| Q1 2021 | 113 | $1.6B | 20,839,029 | 15 | 48 | 27 | 0.4% |
| Q4 2020 | 106 | $1.1B | 18,536,432 | 19 | 34 | 30 | 0.3% |
| Q3 2020 | 96 | $822.8M | 19,044,455 | 4 | 42 | 32 | 0.2% |
| Q2 2020 | 108 | $785.9M | 18,883,340 | 32 | 46 | 20 | 0.3% |
| Q1 2020 | 88 | $924.2M | 21,337,460 | 14 | 32 | 28 | 0.0% |
| Q4 2019 | 87 | $823.2M | 14,849,720 | 11 | 30 | 30 | 0.0% |
| Q3 2019 | 83 | $513.3M | 14,722,738 | 14 | 34 | 19 | 0.0% |
| Q2 2019 | 74 | $426.1M | 10,539,229 | 28 | 26 | 14 | 0.0% |
| Q1 2019 | 57 | $223.1M | 6,714,667 | 17 | 17 | 16 | 0.0% |
| Q4 2018 | 45 | $130.3M | 6,269,192 | 2 | 1 | 1 | 0.0% |