DaveManuel.com · Institutional Ownership · Who Owns It
UPSTREAM BIO INC (UPB)
Institutional ownership reported to the SEC as of Q2 2026, across 8 quarters.
150
Reporting holders
$350.4M
Reported value
92.3%
Of shares outstanding
0.1%
Calls
0.0%
Puts
+7
Holder change
Institutions report 50,571,226 shares against 54,771,041 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $56.5M | 8,162,897 | 0.00% | 7q | +0.8%+$424.4K |
| ORBIMED ADVISORS LLC | $39.4M | 5,693,589 | 0.73% | 7q | HELD |
| NORGES BANK | $26.1M | 3,768,619 | 0.00% | 5q | +30.7%+$6.1M |
| BlackRock, Inc. | $26.0M | 3,753,358 | 0.00% | 7q | +11.4%+$2.6M |
| Decheng Capital LLC | $18.9M | 2,724,868 | 2.58% | 7q | HELD |
| ENAVATE SCIENCES GP, LLC | $17.0M | 2,459,703 | 4.93% | 7q | HELD |
| VANGUARD CAPITAL MANAGEMENT LLC | $13.0M | 1,876,734 | 0.00% | 2q | HELD |
| MILLENNIUM MANAGEMENT LLC | $7.9M | 1,143,775 | 0.00% | 4q | +22.0%+$1.4M |
| D. E. Shaw & Co., Inc. | $7.2M | 1,036,044 | 0.00% | 3q | +26.3%+$1.5M |
| JPMORGAN CHASE & CO | $7.0M | 1,012,044 | 0.00% | 7q | +118.6%+$3.8M |
| Qube Research & Technologies Ltd | $6.8M | 978,500 | 0.01% | 2q | +58.0%+$2.5M |
| Parkman Healthcare Partners LLC | $6.5M | 935,247 | 0.66% | 6q | +18.9%+$1.0M |
| GEODE CAPITAL MANAGEMENT, LLC | $6.4M | 931,261 | 0.00% | 7q | -2.0%-$134.0K |
| SEB Asset Management AB | $6.1M | 878,473 | 0.02% | 2q | HELD |
| Woodline Partners LP | $5.8M | 831,481 | 0.02% | 7q | HELD |
| STATE STREET CORP | $5.3M | 766,323 | 0.00% | 7q | +8.6%+$421.9K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4.9M | 712,667 | 0.00% | 2q | -2.1%-$104.1K |
| Y-Intercept (Hong Kong) Ltd | $4.8M | 693,555 | 0.09% | 3q | -30.7%-$2.1M |
| Bain Capital Life Sciences Investors, LLC | $4.2M | 600,949 | 0.25% | 7q | -30.7%-$1.8M |
| AQR CAPITAL MANAGEMENT LLC | $3.8M | 544,869 | 0.00% | 6q | +655.0%+$3.3M |
| MORGAN STANLEY | $3.6M | 524,632 | 0.00% | 7q | -5.1%-$193.6K |
| BNP PARIBAS FINANCIAL MARKETS | $3.5M | 511,546 | 0.00% | 7q | +306.0%+$2.7M |
| Walleye Capital LLC | $3.4M | 498,490 | 0.01% | new | NEW |
| Trexquant Investment LP | $3.2M | 466,430 | 0.02% | 3q | +164.0%+$2.0M |
| Point72 Asset Management, L.P. | $3.1M | 453,011 | 0.00% | 3q | +154.3%+$1.9M |
| BANK OF AMERICA CORP /DE/ | $2.7M | 391,762 | 0.00% | 7q | +708.4%+$2.4M |
| DIMENSIONAL FUND ADVISORS LP | $2.6M | 381,613 | 0.00% | 2q | +377.0%+$2.1M |
| Altshuler Shaham Ltd | $2.6M | 380,061 | 0.03% | 6q | HELD |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2.5M | 357,756 | 0.00% | 2q | +93.3%+$1.2M |
| SAMSARA BIOCAPITAL, LLC | $2.4M | 353,717 | 0.20% | 7q | -51.9%-$2.6M |
| Propel Bio Management, LLC | $2.4M | 350,389 | 1.27% | 2q | +2.5%+$59.6K |
| WELLINGTON MANAGEMENT GROUP LLP | $2.4M | 342,353 | 0.00% | 7q | HELD |
| NORTHERN TRUST CORP | $2.1M | 297,346 | 0.00% | 7q | +13.9%+$251.6K |
| Squarepoint Ops LLC | $2.0M | 290,904 | 0.00% | 2q | +551.9%+$1.7M |
| Voleon Capital Management LP | $2.0M | 285,234 | 0.04% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1.8M | 262,456 | 0.00% | 7q | +1.8%+$32.7K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1.8M | 253,092 | 0.01% | new | NEW |
| GOLDMAN SACHS GROUP INC | $1.7M | 246,917 | 0.00% | 4q | -22.0%-$482.1K |
| XTX Topco Ltd | $1.7M | 242,346 | 0.02% | 3q | +15.8%+$228.8K |
| DEUTSCHE BANK AG\ | $1.7M | 241,447 | 0.00% | 7q | +33.5%+$419.1K |
| VANGUARD FIDUCIARY TRUST CO | $1.7M | 239,616 | 0.00% | 2q | +6.9%+$107.0K |
| UBS Group AG | $1.6M | 234,714 | 0.00% | 7q | +1.5%+$23.9K |
| Schonfeld Strategic Advisors LLC | $1.6M | 225,760 | 0.01% | 6q | +39.9%+$445.7K |
| Jump Financial, LLC | $1.5M | 223,223 | 0.01% | 2q | -30.1%-$665.5K |
| SPHERA FUNDS MANAGEMENT LTD. | $1.5M | 219,700 | 0.20% | 2q | -38.6%-$957.0K |
| ACADIAN ASSET MANAGEMENT LLC | $1.2M | 175,110 | 0.00% | new | NEW |
| HRT FINANCIAL LP | $1.2M | 170,590 | 0.00% | new | NEW |
| Boxer Capital Management, LLC | $1.0M | 150,000 | 0.08% | 3q | HELD |
| RENAISSANCE TECHNOLOGIES LLC | $908.6K | 131,300 | 0.00% | 3q | +111.4%+$478.9K |
| EntryPoint Capital, LLC | $895.8K | 129,446 | 0.22% | 2q | +76.0%+$386.7K |
| ALGERT GLOBAL LLC | $820.9K | 118,630 | 0.01% | new | NEW |
| Bank of New York Mellon Corp | $593.4K | 85,747 | 0.00% | 7q | +5.4%+$30.2K |
| Nuveen, LLC | $586.6K | 84,770 | 0.00% | 6q | +12.2%+$63.9K |
| AMERICAN CENTURY COMPANIES INC | $541.1K | 78,194 | 0.00% | 5q | -10.8%-$65.3K |
| Man Group plc | $510.9K | 73,823 | 0.00% | 2q | +249.0%+$364.5K |
| GSA CAPITAL PARTNERS LLP | $480.0K | 69,348 | 0.03% | 2q | +76.8%+$208.5K |
| ALLIANCEBERNSTEIN L.P. | $465.1K | 51,680 | 0.00% | 7q | +66.7%+$186.0K |
| Simplify Asset Management Inc. | $429.8K | 62,113 | 0.01% | 2q | -20.2%-$108.5K |
| ALPS ADVISORS INC | $382.2K | 55,228 | 0.00% | 7q | +25.5%+$77.8K |
| Quantinno Capital Management LP | $379.5K | 54,838 | 0.00% | 6q | +11.0%+$37.7K |
| Virtus Investment Advisers, LLC | $371.2K | 53,638 | 0.09% | 5q | +433.9%+$301.7K |
| Invesco Ltd. | $369.5K | 53,397 | 0.00% | 7q | +31.8%+$89.2K |
| Brevan Howard Capital Management LP | $348.6K | 50,369 | 0.00% | new | NEW |
| Swiss National Bank | $332.9K | 48,100 | 0.00% | 3q | HELD |
| Russell Investments Group, Ltd. | $329.0K | 47,543 | 0.00% | 5q | +1203.6%+$303.8K |
| Allspring Global Investments Holdings, LLC | $298.8K | 43,182 | 0.00% | new | NEW |
| RHUMBLINE ADVISERS | $293.3K | 42,384 | 0.00% | 7q | +2.9%+$8.2K |
| TWO SIGMA INVESTMENTS, LP | $292.9K | 42,325 | 0.00% | new | NEW |
| ExodusPoint Capital Management, LP | $284.0K | 41,045 | 0.00% | 3q | -55.1%-$348.7K |
| CITIGROUP INC | $279.1K | 40,339 | 0.00% | 7q | +698.0%+$244.2K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $267.3K | 38,634 | 0.00% | 7q | -2.6%-$7.1K |
| Stonepine Capital Management, LLC | $231.3K | 33,432 | 0.13% | 2q | -4.5%-$10.9K |
| Mariner, LLC | $229.3K | 33,141 | 0.00% | 4q | +21.3%+$40.3K |
| WELLS FARGO & COMPANY/MN | $204.1K | 29,497 | 0.00% | 7q | +60.3%+$76.8K |
| BARCLAYS PLC | $202.1K | 29,208 | 0.00% | 7q | +18.2%+$31.1K |
| Creative Planning | $197.1K | 28,483 | 0.00% | 5q | +162.5%+$122.0K |
| PRICE T ROWE ASSOCIATES INC /MD/ | $195.0K | 28,058 | 0.00% | 5q | +6.1%+$11.3K |
| Quantbot Technologies LP | $195.0K | 28,178 | 0.01% | 2q | +4150.1%+$190.4K |
| JANE STREET GROUP, LLC | $190.3K incl. $82.3K options CALL | 15,594 | 0.00% | 2q | HELD |
| AXQ CAPITAL, LP | $187.3K | 27,068 | 0.02% | 2q | -1.6%-$3.0K |
| nVerses Capital, LLC | $166.3K | 24,029 | 0.26% | new | NEW |
| DNB Asset Management AS | $163.3K | 23,600 | 0.00% | 3q | HELD |
| VANGUARD ASSET MANAGEMENT, Ltd | $157.2K | 22,724 | 0.00% | 2q | +145.7%+$93.2K |
| Graham Capital Management, L.P. | $155.8K | 22,508 | 0.00% | new | NEW |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154.9K | 22,385 | 0.00% | new | NEW |
| Verdad Advisers, LP | $150.9K | 21,810 | 0.14% | new | NEW |
| MetLife Investment Management, LLC | $144.3K | 20,852 | 0.00% | 7q | +7.6%+$10.2K |
| SG Americas Securities, LLC | $141.0K | 20,338 | 0.00% | new | NEW |
| SEI INVESTMENTS CO | $138.6K | 20,026 | 0.00% | new | NEW |
| WINTON GROUP Ltd | $137.0K | 19,800 | 0.00% | new | NEW |
| IEQ CAPITAL, LLC | $135.2K | 19,535 | 0.00% | new | NEW |
| DIADEMA PARTNERS LP | $132.1K | 19,093 | 0.02% | 4q | -11.6%-$17.4K |
| Shay Capital LLC | $124.6K | 18,000 | 0.01% | 2q | +80.0%+$55.4K |
| Quadrature Capital Ltd | $124.5K | 17,988 | 0.00% | new | NEW |
| Entropy Technologies, LP | $121.4K | 17,542 | 0.00% | 2q | -24.8%-$40.1K |
| STATE OF WISCONSIN INVESTMENT BOARD | $118.1K | 17,065 | 0.00% | 2q | -59.0%-$170.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112.2K | 16,217 | 0.00% | 7q | +3.9%+$4.2K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108.9K | 15,735 | 0.00% | 5q | +2.6%+$2.7K |
| CITADEL ADVISORS LLC | $103.8K CALL | options only | 0.00% | 4q | OPTIONS |
| MERCER GLOBAL ADVISORS INC /ADV | $92.4K | 13,352 | 0.00% | new | NEW |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-10-29 | 13G/A | Decheng Capital Global Life Sciences Fund IV, L.P.with 2 co-filers | 4.9% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 17 | $3.8M | 726,068 | 5 | 6 | 5 | 0.0% |
| Q2 2026 | 150 | $350.4M | 50,571,226 | 35 | 64 | 29 | 0.1% |
| Q1 2026 | 143 | $406.3M | 44,886,510 | 40 | 47 | 35 | 0.5% |
| Q4 2025 | 135 | $1.4B | 51,176,304 | 39 | 41 | 32 | 0.2% |
| Q3 2025 | 101 | $845.4M | 44,491,763 | 31 | 36 | 21 | 1.0% |
| Q2 2025 | 83 | $531.0M | 48,356,864 | 13 | 40 | 13 | 0.0% |
| Q1 2025 | 79 | $266.9M | 46,279,293 | 23 | 11 | 25 | 0.0% |
| Q4 2024 | 70 | $690.1M | 42,074,592 | 67 | 0 | 0 | 0.0% |