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DaveManuel.com · Institutional Ownership · 13F Holdings

Propel Bio Management, LLC

Reported holdings as of Q2 2026, from 11 quarterly filings.

CIK
1969764
Reported value
$191.1M
Positions
29
Top 10 weight
68.1%
Filed
2026-08-13
Days after quarter end
44

Holdings

Download these holdings as CSV

SecurityTickerValue SharesWeightWeight change Held Change
PLAINS GP HLDGS L PPAGP$30.9M1,272,36016.16%-2.86pp9qHELD
ACHIEVE LIFE SCIENCE INCACHV$26.3M4,034,01813.79%+6.62pp10q+6.5%+$1.6M
CORCEPT THERAPEUTICS INCCORT$11.9M136,4996.21%+2.42pp2q-7.7%-$985.1K
PHATHOM PHARMACEUTICALS INCPHAT$11.4M1,050,3585.96%+0.07pp11q+24.9%+$2.3M
DELCATH SYS INCDCTH$11.0M871,4605.74%-0.03pp7q-11.0%-$1.4M
MILESTONE PHARMACEUTICALS INMIST$10.0M7,429,5905.21%+2.01pp6q+80.4%+$4.4M
COMPASS PATHWAYS PLCCMPS$8.1M573,0864.24%+1.65pp4q-22.8%-$2.4M
KYVERNA THERAPEUTICS INCKYTX$7.9M883,1984.12%+0.60pp3q+37.1%+$2.1M
ARTIVA BIOTHERAPEUTICS INCARTV$6.8M696,4363.54%+2.94pp2q+375.8%+$5.3M
ABEONA THERAPEUTICS INCABEO$6.1M983,0703.18%-0.61pp9q-26.1%-$2.1M
AQUESTIVE THERAPEUTICS INCAQST$6.0M1,442,3973.14%+1.28pp2q+102.9%+$3.0M
PALISADE BIO INC COMPALI$5.4M2,582,3882.82%+1.57pp2q+131.6%+$3.1M
IMMUNIC INCIMUX$5.0M325,0222.61%-newNEW
INVENTIVA SAIVA$4.8M1,281,2122.53%+0.02pp3q+76.8%+$2.1M
SAB BIOTHERAPEUTICS INCSABS$4.2M1,076,5782.20%-0.25pp3q+6.3%+$248.8K
ORCHESTRA BIOMED HLDGS INCOBIO$3.9M896,7012.02%-0.39pp2qHELD
CELLDEX THERAPEUTICS INC NEWCLDX$3.9M103,6952.02%-0.59pp4q-21.1%-$1.0M
ZEVRA THERAPEUTICS INCZVRA$3.6M253,5441.90%+0.24pp8q-10.2%-$414.1K
OCULAR THERAPEUTIX INCOCUL$3.5M357,9661.84%-0.19pp2q-6.4%-$239.7K
4D MOLECULAR THERAPEUTICS INFDMT$3.4M252,6541.76%-0.50pp2q-33.6%-$1.7M
OVID THERAPEUTICS INCOVID$3.0M1,115,5381.57%+0.29pp2q+21.1%+$522.1K
EYEPOINT PHARMACEUTICALS INCEYPT$2.7M191,7451.43%-0.32pp2q-11.2%-$344.3K
UPSTREAM BIO INCUPB$2.4M350,3891.27%-0.69pp2q+2.5%+$59.6K
SCYNEXIS INC COMSCYX$2.2M543,4781.16%-newNEW
SILENCE THERAPEUTICS ADR REP 3 ORDSLN$2.1M191,7331.10%-newNEW
LEONABIO INCLONA$1.4M149,2790.72%-0.22pp4qHELD
MAZE THERAPEUTICS INCMAZE$1.3M43,7980.68%-0.14pp2qHELD
CORVUS PHARMACEUTICALS INCCRVS$1.1M70,3800.55%-0.24pp2q-18.0%-$230.2K
SAGIMET BIOSCIENCES INCSGMT$973.0K125,8780.51%-newNEW

By sector

Industry comes from the SIC code on each company's own SEC filings, which is self-reported and sometimes out of date. Derivative exposure is counted with the shares. Securities the SEC assigns no industry - funds, trusts, foreign issues - are shown as not classified rather than dropped.

Biotech & Pharma 76.1%Transport & Logistics 16.2%Medical Devices 7.8%
 
SectorValueShare
Biotech & Pharma$145.4M76.1%
Transport & Logistics$30.9M16.2%
Medical Devices$14.8M7.8%

What the disclosed book did

This is not the fund's return. A 13F shows long US equity positions only, so shorts, bonds, foreign listings, private holdings and cash are all invisible here. What this measures is the quarter's change in value of the positions this manager disclosed, had they been left untouched - the return a reader following the filing would have earned.

QuarterBookMarket DifferencePriced
Q2 2026+25.0%+14.8%+10.2%98%
Q1 2026-9.0%-4.6%-4.4%100%
Q4 2025+4.5%+2.4%+2.1%89%
Q3 2025+9.6%+7.8%+1.8%98%
Q2 2025+3.1%+10.5%-7.4%98%
Q1 2025-4.5%-4.6%+0.0%99%
Q4 2024-40.3%+2.1%-42.5%99%
Q3 2024+17.3%+5.4%+11.9%98%

Market is SPY over the same two quarter ends, priced the same way as everything else here - the median across every filer reporting it. It is a large-cap US proxy, so a manager holding small caps or biotech will beat or trail it for reasons that are not skill. Prices are quarter-end to quarter-end and say nothing about the path in between, or about trades opened and closed inside a quarter.

Quarter by quarter

QuarterValuePositions NewAddedTrimmed ExitedTop 10 Days to file
Q2 2026$191.1M29411101368.1%44
Q1 2026$158.7M382266458.3%44
Q4 2025$117.1M20843483.9%42
Q3 2025$99.9M16623687.1%43
Q2 2025$82.4M16252497.5%44
Q1 2025$86.1M18242591.7%45
Q4 2024$100.7M21242290.3%45
Q3 2024$172.4M21333690.8%44
Q2 2024$154.2M24440883.3%43
Q1 2024$171.8M285511082.9%43
Q4 2023$120.6M33000071.6%45

Rows marked UNVERIFIED ID, PLACEHOLDER ID, TICKER AS ID or NON-CUSIP ID carry an identifier that is not a valid CUSIP. They are shown because the filer reported that money, but treat the security named with caution - hover the chip for what is wrong with it, and see the methodology.

Held counts consecutive filings in which this manager reported the position, and can reach further back than the quarters listed above: the tabs begin at Q4 2018 because earlier coverage is too sparse to describe a market, but tenure is counted over every filing we hold, some reaching to 2007. A position sold and later rebought starts again from one.

Weight change is the shift in this position's share of the whole book, in percentage points. It is the more useful column: when money flows into or out of a broad fund, almost every holding is bought or sold at once, so added and trimmed largely track flows. A weight that rose while the book shrank is a decision. Both compare with the previous quarter this filer reported, not the previous calendar quarter.