DaveManuel.com · Institutional Ownership · Who Owns It
XENON PHARMACEUTICALS INC (XENE)
Institutional ownership reported to the SEC as of Q2 2026, across 32 quarters.
322
Reporting holders
$6.2B
Reported value
104.5%
Of shares outstanding
1.0%
Calls
0.1%
Puts
+23
Holder change
Institutions report 101,200,091 shares against 96,840,432 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $582.4M | 9,647,998 | 0.03% | 26q | -10.8%-$70.7M |
| BlackRock, Inc. | $454.1M | 7,522,482 | 0.01% | 8q | +33.4%+$113.6M |
| Avoro Capital Advisors LLC | $348.7M | 5,777,777 | 3.13% | 31q | HELD |
| Polar Capital Holdings Plc | $275.9M | 4,570,556 | 0.65% | 19q | +3.8%+$10.0M |
| Driehaus Capital Management LLC | $266.7M | 4,418,557 | 1.55% | 26q | -1.6%-$4.4M |
| Jupiter Topco LLC | $252.7M | 4,186,519 | 0.10% | new | FIRST |
| PRICE T ROWE ASSOCIATES INC /MD/ | $196.1M | 3,248,219 | 0.02% | 5q | +144.3%+$115.8M |
| JPMORGAN CHASE & CO | $157.4M | 2,617,360 | 0.01% | 23q | +36.1%+$41.7M |
| Capital International Investors | $142.5M | 2,361,639 | 0.03% | 31q | -11.7%-$18.9M |
| T. Rowe Price Investment Management, Inc. | $130.9M | 2,168,581 | 0.09% | 11q | +127.8%+$73.4M |
| STATE STREET CORP | $118.9M | 1,969,629 | 0.00% | 31q | +14.5%+$15.0M |
| TWO SIGMA INVESTMENTS, LP | $99.2M | 1,642,848 | 0.07% | 3q | +171.1%+$62.6M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $97.5M | 1,615,696 | 1.02% | 5q | HELD |
| Affinity Asset Advisors, LLC | $96.3M | 1,595,000 | 4.35% | 15q | -4.8%-$4.8M |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $91.0M | 1,507,294 | 0.30% | 11q | +7.5%+$6.4M |
| ALLIANCEBERNSTEIN L.P. | $90.8M | 1,562,276 | 0.03% | 21q | +11.3%+$9.2M |
| CITADEL ADVISORS LLC | $87.4M incl. $2.8M options CALL+PUT | 1,401,242 | 0.01% | 31q | -47.2%-$78.1M |
| FRANKLIN RESOURCES INC | $86.8M | 1,437,712 | 0.02% | 14q | +12.3%+$9.5M |
| WELLINGTON MANAGEMENT GROUP LLP | $86.0M | 1,425,492 | 0.01% | 14q | -70.5%-$205.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $82.7M | 1,370,114 | 0.00% | 31q | +25.4%+$16.7M |
| Siren, L.L.C. | $79.6M | 1,318,564 | 1.61% | 8q | HELD |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $77.9M | 1,290,731 | 0.08% | 10q | -3.8%-$3.1M |
| Pictet Asset Management Holding SA | $71.6M | 1,187,723 | 0.07% | 12q | +74.7%+$30.6M |
| BRAIDWELL LP | $68.3M | 1,131,452 | 2.53% | 15q | -15.5%-$12.5M |
| Nuveen, LLC | $59.9M | 993,126 | 0.01% | 5q | +297.2%+$44.9M |
| Invesco Ltd. | $54.5M | 903,458 | 0.00% | 14q | +1428.6%+$51.0M |
| ORBIMED ADVISORS LLC | $53.9M | 892,471 | 1.00% | 31q | -15.8%-$10.1M |
| Caligan Partners LP | $53.7M | 889,944 | 2.53% | 4q | -36.1%-$30.4M |
| AMERICAN CENTURY COMPANIES INC | $53.4M | 884,319 | 0.02% | 5q | +30.2%+$12.4M |
| FEDERATED HERMES, INC. | $53.3M | 883,737 | 0.08% | 11q | -9.1%-$5.3M |
| Capital World Investors | $52.1M | 862,775 | 0.01% | 31q | +2.7%+$1.4M |
| GOLDMAN SACHS GROUP INC | $46.7M | 773,625 | 0.00% | 25q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $45.2M | 749,651 | 0.00% | 2q | +38.0%+$12.5M |
| Caption Management, LLC | $43.9M CALL | options only | 0.20% | 6q | OPTIONS |
| Vestal Point Capital, LP | $42.3M | 700,000 | 0.99% | 11q | +9.4%+$3.6M |
| Alyeska Investment Group, L.P. | $42.1M | 697,692 | 0.11% | 2q | -46.3%-$36.3M |
| MARSHALL WACE, LLP | $41.6M | 689,342 | 0.03% | new | NEW |
| Rock Springs Capital Management LP | $41.3M | 683,907 | 2.01% | 26q | -10.4%-$4.8M |
| NORTHERN TRUST CORP | $40.5M | 671,566 | 0.00% | 31q | +27.2%+$8.7M |
| PANAGORA ASSET MANAGEMENT INC | $40.1M | 664,031 | 0.12% | new | NEW |
| First Turn Management, LLC | $36.2M | 600,200 | 3.88% | 11q | -23.7%-$11.3M |
| TUDOR INVESTMENT CORP ET AL | $32.9M | 545,387 | 0.05% | 4q | +10.0%+$3.0M |
| LOOMIS SAYLES & CO L P | $31.8M | 527,273 | 0.04% | 15q | -6.7%-$2.3M |
| Octagon Capital Advisors LP | $29.6M | 490,000 | 2.66% | 2q | HELD |
| NOVO HOLDINGS A/S | $29.3M | 485,438 | 1.70% | 2q | HELD |
| Candriam S.C.A. | $27.9M | 462,768 | 0.13% | 21q | -2.9%-$827.7K |
| TimesSquare Capital Management, LLC | $27.3M | 451,593 | 0.40% | 15q | +25.7%+$5.6M |
| Logos Global Management LP | $27.2M | 450,000 | 1.17% | 2q | HELD |
| Trails Edge Capital Partners, LP | $26.6M | 440,000 | 4.22% | 3q | HELD |
| Bank of New York Mellon Corp | $25.4M | 421,518 | 0.00% | 29q | +6.4%+$1.5M |
| ALGERT GLOBAL LLC | $25.3M | 419,773 | 0.30% | 18q | +58.9%+$9.4M |
| Aberdeen Group plc | $24.7M | 408,736 | 0.03% | 11q | -33.0%-$12.1M |
| MORGAN STANLEY | $24.5M | 406,257 | 0.00% | 35q | -14.2%-$4.1M |
| Fiera Capital Corp | $24.5M | 405,638 | 0.09% | 13q | -42.8%-$18.3M |
| BANK OF AMERICA CORP /DE/ | $24.4M | 404,067 | 0.00% | 25q | +52.3%+$8.4M |
| Parkman Healthcare Partners LLC | $24.0M | 397,379 | 2.46% | 27q | -20.1%-$6.0M |
| Nicholas Investment Partners, LP | $23.9M | 395,844 | 1.35% | 8q | +60.2%+$9.0M |
| MILLENNIUM MANAGEMENT LLC | $22.7M | 376,777 | 0.01% | 27q | +86.7%+$10.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $22.6M | 374,748 | 0.00% | 3q | HELD |
| BAKER BROS. ADVISORS LP | $22.3M | 370,208 | 0.11% | 25q | HELD |
| Jones Hill Capital LP | $22.2M | 367,900 | 4.72% | new | NEW |
| AMERIPRISE FINANCIAL INC | $19.2M | 318,548 | 0.00% | 8q | +303.7%+$14.5M |
| Man Group plc | $18.7M | 310,617 | 0.03% | new | NEW |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $18.1M | 300,000 | 0.03% | 31q | -36.2%-$10.3M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $17.2M incl. $15.8M options CALL+PUT | 22,258 | 0.00% | 22q | -87.4%-$119.4M |
| Soleus Capital Management, L.P. | $16.1M | 267,000 | 0.56% | 2q | -8.6%-$1.5M |
| Jump Financial, LLC | $15.7M | 260,730 | 0.13% | 5q | +67.4%+$6.3M |
| DAFNA Capital Management LLC | $15.1M | 250,772 | 2.89% | 31q | HELD |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $15.1M | 249,473 | 0.00% | 5q | +31.9%+$3.6M |
| STATE OF WISCONSIN INVESTMENT BOARD | $15.0M | 248,821 | 0.03% | 18q | -2.2%-$341.8K |
| NAN FUNG TRINITY (HK) LTD | $15.0M | 247,765 | 1.48% | 5q | HELD |
| Duquesne Family Office LLC | $14.4M | 238,600 | 0.28% | 2q | HELD |
| Allspring Global Investments Holdings, LLC | $14.1M | 234,412 | 0.02% | 2q | -4.8%-$717.2K |
| Redmile Group, LLC | $13.8M | 229,374 | 0.93% | 3q | -12.7%-$2.0M |
| Schonfeld Strategic Advisors LLC | $13.7M | 227,330 | 0.05% | 2q | -30.0%-$5.9M |
| D. E. Shaw & Co., Inc. | $13.5M | 223,922 | 0.01% | 31q | +1082.3%+$12.4M |
| Patient Square Capital LP | $13.3M | 220,000 | 2.06% | 3q | -3.1%-$422.5K |
| NEW YORK STATE COMMON RETIREMENT FUND | $12.7M | 210,471 | 0.02% | 19q | +11.7%+$1.3M |
| JENNISON ASSOCIATES LLC | $12.6M | 208,060 | 0.01% | 13q | -84.2%-$67.0M |
| NEUBERGER BERMAN GROUP LLC | $12.5M | 206,604 | 0.01% | 7q | +58.4%+$4.6M |
| Trexquant Investment LP | $12.2M | 202,455 | 0.07% | 2q | +200.6%+$8.2M |
| DNB Asset Management AS | $12.1M | 200,451 | 0.03% | 15q | +10.7%+$1.2M |
| Integral Health Asset Management, LLC | $12.1M | 200,000 | 0.48% | 2q | HELD |
| Eversept Partners, LP | $11.9M | 196,532 | 0.62% | 3q | +51.7%+$4.0M |
| Balyasny Asset Management L.P. | $11.7M | 193,407 | 0.01% | 11q | -17.3%-$2.4M |
| DEUTSCHE BANK AG\ | $11.5M | 191,126 | 0.00% | 15q | +17.5%+$1.7M |
| RENAISSANCE TECHNOLOGIES LLC | $11.3M | 187,110 | 0.02% | 2q | -37.7%-$6.8M |
| SILVERARC CAPITAL MANAGEMENT, LLC | $11.3M | 186,821 | 1.17% | 2q | -5.5%-$660.2K |
| BOOTHBAY FUND MANAGEMENT, LLC | $11.1M | 183,343 | 0.15% | 4q | -32.2%-$5.3M |
| NEXTBio Capital Management LP | $11.1M | 183,225 | 5.09% | 3q | HELD |
| WELLS FARGO & COMPANY/MN | $10.5M | 173,945 | 0.00% | 16q | +50.4%+$3.5M |
| ADAR1 Capital Management, LLC | $10.1M | 166,550 | 0.46% | 9q | -27.2%-$3.8M |
| PEREGRINE CAPITAL MANAGEMENT LLC | $10.0M | 164,894 | 0.32% | 3q | +15.2%+$1.3M |
| Swiss National Bank | $9.8M | 162,700 | 0.01% | 25q | +3.2%+$301.8K |
| Foresite Capital Management IV, LLC | $9.7M | 160,000 | 3.33% | 5q | HELD |
| Woodline Partners LP | $9.4M | 155,302 | 0.03% | 2q | +3.3%+$301.8K |
| Russell Investments Group, Ltd. | $9.2M | 153,227 | 0.01% | 19q | +18.4%+$1.4M |
| HSBC HOLDINGS PLC | $9.1M | 151,474 | 0.00% | 2q | +24.6%+$1.8M |
| Susquehanna Portfolio Strategies, LLC | $8.0M | 133,059 | 0.13% | 2q | +620.5%+$6.9M |
| Point72 Asset Management, L.P. | $7.9M | 130,378 | 0.01% | 3q | HELD |
Showing the largest 100 of 322 reported holders.
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-09-30 | MORTIMER IAN | PRESIDENT & CEO | Bought | 30,000 | $1.1M |
| 2026-08-11 | GANNON STEVEN | Director | Sold | 10,000 | $640.6K |
| 2026-09-30 | Kelly Thomas Patrick | Chief Financial Officer | Bought | 15,000 | $559.7K |
| 2026-08-28 | KENNEY CHRISTOPHER JOHN | Chief Medical Officer | Sold | 7,068 | $425.8K ×2 |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 39 | $22.4M | 601,520 | 7 | 15 | 11 | 0.0% |
| Q2 2026 | 322 | $6.2B | 101,200,091 | 47 | 122 | 82 | 1.2% |
| Q1 2026 | 299 | $6.1B | 100,518,520 | 74 | 122 | 57 | 4.4% |
| Q4 2025 | 256 | $3.9B | 84,702,293 | 50 | 76 | 75 | 2.3% |
| Q3 2025 | 224 | $3.5B | 85,719,919 | 35 | 65 | 71 | 0.7% |
| Q2 2025 | 208 | $2.6B | 83,293,384 | 42 | 72 | 55 | 0.8% |
| Q1 2025 | 212 | $2.6B | 76,774,120 | 22 | 66 | 69 | 0.8% |
| Q4 2024 | 213 | $3.0B | 76,312,001 | 22 | 64 | 66 | 0.1% |
| Q3 2024 | 206 | $3.0B | 75,876,277 | 14 | 69 | 59 | 0.2% |
| Q2 2024 | 213 | $2.9B | 75,008,274 | 20 | 73 | 67 | 0.5% |
| Q1 2024 | 223 | $3.3B | 75,202,311 | 34 | 78 | 64 | 0.9% |
| Q4 2023 | 213 | $3.5B | 73,252,342 | 43 | 85 | 52 | 2.3% |
| Q3 2023 | 184 | $2.2B | 62,525,793 | 23 | 69 | 47 | 1.4% |
| Q2 2023 | 177 | $2.4B | 63,267,986 | 33 | 53 | 55 | 0.3% |
| Q1 2023 | 167 | $2.4B | 67,645,056 | 29 | 51 | 44 | 0.5% |
| Q4 2022 | 162 | $2.5B | 62,525,274 | 23 | 53 | 51 | 0.8% |
| Q3 2022 | 149 | $12.7B | 352,984,930 | 23 | 56 | 42 | 0.1% |
| Q2 2022 | 150 | $17.9B | 587,984,339 | 38 | 54 | 38 | 0.0% |
| Q1 2022 | 134 | $15.1B | 494,441,312 | 17 | 47 | 41 | 0.0% |
| Q4 2021 | 133 | $9.2B | 294,877,136 | 30 | 50 | 28 | 0.2% |
| Q3 2021 | 122 | $574.3M | 34,109,436 | 32 | 32 | 29 | 9.2% |
| Q2 2021 | 101 | $701.2M | 34,931,978 | 16 | 26 | 29 | 0.6% |
| Q1 2021 | 90 | $587.1M | 32,629,350 | 15 | 32 | 23 | 0.5% |
| Q4 2020 | 80 | $425.7M | 27,682,965 | 9 | 21 | 20 | 0.0% |
| Q3 2020 | 76 | $305.1M | 27,556,796 | 3 | 12 | 25 | 0.0% |
| Q2 2020 | 78 | $346.5M | 27,627,777 | 18 | 23 | 9 | 0.0% |
| Q1 2020 | 72 | $1.1B | 99,230,353 | 18 | 20 | 20 | 0.0% |
| Q4 2019 | 68 | $3.1B | 234,117,429 | 13 | 19 | 14 | 0.0% |
| Q3 2019 | 55 | $2.1B | 231,489,148 | 4 | 9 | 18 | 0.0% |
| Q2 2019 | 60 | $2.4B | 241,678,930 | 9 | 18 | 11 | 0.0% |
| Q1 2019 | 63 | $2.5B | 241,852,621 | 9 | 23 | 16 | 0.0% |
| Q4 2018 | 59 | $1.4B | 222,365,254 | 1 | 2 | 1 | 0.0% |