DaveManuel.com · Institutional Ownership · Who Owns It
MAZE THERAPEUTICS INC (MAZE)
Institutional ownership reported to the SEC as of Q2 2026, across 7 quarters.
162
Reporting holders
$1.7B
Reported value
105.4%
Of shares outstanding
0.1%
Calls
0.1%
Puts
-6
Holder change
Institutions report 58,534,416 shares against 55,549,168 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | $150.2M | 5,032,915 | 3.27% | 6q | +10.2%+$13.9M |
| TRV GP IV, LLC | $133.5M | 4,473,958 | 52.63% | 6q | HELD |
| ARCH Venture Management, LLC | $123.0M | 4,120,053 | 11.18% | 6q | HELD |
| Deep Track Capital, LP | $111.4M | 3,732,569 | 1.62% | 6q | +7.3%+$7.6M |
| BlackRock, Inc. | $104.5M | 3,502,841 | 0.00% | 6q | +36.3%+$27.8M |
| Jupiter Topco LLC | $101.8M | 3,408,045 | 0.04% | new | FIRST |
| T. Rowe Price Investment Management, Inc. | $77.7M | 2,603,682 | 0.05% | new | NEW |
| Logos Global Management LP | $57.7M | 1,935,000 | 2.49% | 6q | +56.7%+$20.9M |
| VANGUARD CAPITAL MANAGEMENT LLC | $53.1M | 1,778,222 | 0.00% | 2q | +23.9%+$10.2M |
| a16z Capital Management, L.L.C. | $50.8M | 1,702,225 | 0.36% | 6q | HELD |
| Venrock Adviser, LLC | $47.8M | 1,602,034 | 1.45% | 4q | HELD |
| Alphabet Inc. | $41.4M | 1,388,583 | 0.04% | 6q | HELD |
| BRAIDWELL LP | $34.0M | 1,140,040 | 1.26% | new | NEW |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $33.1M | 1,107,814 | 0.15% | 2q | +197.0%+$21.9M |
| FMR LLC | $31.5M | 1,056,959 | 0.00% | 6q | +22.3%+$5.8M |
| General Catalyst Group Management, LLC | $30.9M | 1,035,910 | 16.40% | 6q | HELD |
| STATE STREET CORP | $29.8M | 997,533 | 0.00% | 6q | +56.7%+$10.8M |
| Driehaus Capital Management LLC | $28.5M | 954,886 | 0.17% | 6q | +50.1%+$9.5M |
| TRV GP V, LLC | $28.4M | 950,800 | 5.69% | 6q | HELD |
| JPMORGAN CHASE & CO | $28.0M | 964,011 | 0.00% | 6q | +1549.4%+$26.3M |
| MARSHALL WACE, LLP | $27.3M | 914,572 | 0.02% | 6q | +194.4%+$18.0M |
| CITADEL ADVISORS LLC | $26.1M incl. $662.4K options CALL+PUT | 852,676 | 0.00% | 3q | +9.9%+$2.4M |
| GEODE CAPITAL MANAGEMENT, LLC | $25.6M | 858,054 | 0.00% | 6q | +43.0%+$7.7M |
| Casdin Capital, LLC | $25.2M | 843,857 | 1.26% | 6q | +11.2%+$2.5M |
| ArrowMark Colorado Holdings LLC | $22.9M | 767,383 | 0.95% | 4q | HELD |
| Woodline Partners LP | $22.0M | 736,216 | 0.07% | 6q | +13.2%+$2.6M |
| BESSEMER GROUP INC | $14.4M | 481,790 | 0.02% | 6q | HELD |
| SPHERA FUNDS MANAGEMENT LTD. | $12.5M | 417,564 | 1.63% | 6q | +83.7%+$5.7M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $11.7M | 393,107 | 0.00% | 2q | +101.0%+$5.9M |
| Aberdeen Group plc | $11.5M | 383,773 | 0.02% | 2q | +69.6%+$4.7M |
| Ikarian Capital, LLC | $11.3M | 378,999 | 1.22% | 6q | HELD |
| HHLR ADVISORS, LTD. | $10.9M | 366,028 | 1.31% | 6q | HELD |
| ADAR1 Capital Management, LLC | $10.1M | 339,276 | 0.46% | 4q | +577.3%+$8.6M |
| Squadron Capital Management LLC | $10.0M | 335,000 | 3.10% | 3q | +30.1%+$2.3M |
| BANK OF AMERICA CORP /DE/ | $9.6M | 321,227 | 0.00% | 6q | +64.7%+$3.8M |
| NORTHERN TRUST CORP | $8.8M | 294,742 | 0.00% | 6q | +39.4%+$2.5M |
| GOLDMAN SACHS GROUP INC | $8.7M | 293,144 | 0.00% | 3q | +4.8%+$400.8K |
| Candriam S.C.A. | $8.2M | 273,932 | 0.04% | 2q | -1.5%-$126.3K |
| Hudson Bay Capital Management LP | $8.1M | 270,000 | 0.02% | 2q | +3212.9%+$7.8M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7.8M | 260,566 | 0.00% | 6q | +39.8%+$2.2M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $7.4M | 248,000 | 0.01% | 2q | -78.9%-$27.8M |
| Mass General Brigham, Inc | $7.2M | 239,994 | 1.98% | 3q | HELD |
| AMERIPRISE FINANCIAL INC | $6.8M | 227,425 | 0.00% | 3q | +111.6%+$3.6M |
| VANGUARD FIDUCIARY TRUST CO | $6.6M | 219,938 | 0.00% | 2q | +45.7%+$2.1M |
| RTW INVESTMENTS, LP | $6.3M | 212,000 | 0.05% | new | NEW |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $5.8M | 199,872 | 0.00% | 2q | +437.6%+$4.7M |
| TWO SIGMA INVESTMENTS, LP | $5.8M | 192,952 | 0.00% | 4q | +1117.7%+$5.3M |
| BOOTHBAY FUND MANAGEMENT, LLC | $5.6M | 188,857 | 0.07% | 6q | -33.6%-$2.9M |
| ExodusPoint Capital Management, LP | $5.5M | 183,264 | 0.04% | new | NEW |
| SummitTX Capital, L.P. | $5.3M | 176,291 | 0.14% | 3q | +110.5%+$2.8M |
| HighVista Strategies LLC | $4.1M | 136,572 | 0.93% | 3q | +36.8%+$1.1M |
| MORGAN STANLEY | $4.0M | 135,168 | 0.00% | 6q | -34.0%-$2.1M |
| PRICE T ROWE ASSOCIATES INC /MD/ | $4.0M | 132,870 | 0.00% | 4q | +8.3%+$303.6K |
| Qube Research & Technologies Ltd | $3.9M | 131,043 | 0.00% | 2q | -2.9%-$116.6K |
| Walleye Capital LLC | $3.8M | 128,006 | 0.01% | 2q | +358.1%+$3.0M |
| Exome Asset Management LLC | $3.4M | 114,692 | 2.11% | 2q | +29.6%+$781.3K |
| Ensign Peak Advisors, Inc | $3.0M | 101,644 | 0.00% | 5q | -45.3%-$2.5M |
| Alyeska Investment Group, L.P. | $3.0M | 100,000 | 0.01% | 6q | HELD |
| Bank of New York Mellon Corp | $2.9M | 97,588 | 0.00% | 6q | +31.4%+$695.9K |
| ALGERT GLOBAL LLC | $2.8M | 93,357 | 0.03% | new | NEW |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2.6M incl. $1.9M options CALL+PUT | 23,677 | 0.00% | 6q | -6.4%-$180.5K |
| UBS Group AG | $2.5M | 84,679 | 0.00% | 6q | -9.8%-$275.1K |
| WELLINGTON MANAGEMENT GROUP LLP | $2.5M | 82,724 | 0.00% | 3q | +36.5%+$660.6K |
| Trexquant Investment LP | $2.4M | 81,668 | 0.01% | new | NEW |
| FRANKLIN RESOURCES INC | $2.4M | 80,216 | 0.00% | 4q | +34.5%+$614.1K |
| Nuveen, LLC | $2.3M | 78,468 | 0.00% | 6q | +23.8%+$450.8K |
| OSAIC HOLDINGS, INC. | $2.3M | 77,850 | 0.00% | 5q | +29.9%+$534.3K |
| BNP PARIBAS FINANCIAL MARKETS | $2.3M | 77,251 | 0.00% | 6q | +1093.1%+$2.1M |
| XTX Topco Ltd | $2.2M | 75,317 | 0.03% | 4q | +180.5%+$1.4M |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $2.2M | 74,384 | 0.01% | 3q | +689.6%+$1.9M |
| RAYMOND JAMES FINANCIAL INC | $2.0M | 66,353 | 0.00% | 3q | -4.4%-$90.2K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2.0M | 65,468 | 0.01% | new | NEW |
| DAFNA Capital Management LLC | $1.9M | 65,000 | 0.37% | 2q | +85.7%+$895.2K |
| ALPS ADVISORS INC | $1.7M | 55,970 | 0.01% | 2q | +42.9%+$501.3K |
| Jump Financial, LLC | $1.4M | 47,129 | 0.01% | new | NEW |
| Swiss National Bank | $1.4M | 47,100 | 0.00% | new | NEW |
| FIRST TRUST ADVISORS LP | $1.4M | 46,227 | 0.00% | 2q | +81.4%+$618.9K |
| Propel Bio Management, LLC | $1.3M | 43,798 | 0.68% | 2q | HELD |
| RHUMBLINE ADVISERS | $1.3M | 42,873 | 0.00% | 6q | +36.0%+$339.0K |
| NOMURA HOLDINGS INC | $1.3M CALL+PUT | options only | 0.00% | 2q | OPTIONS |
| ALLIANCEBERNSTEIN L.P. | $1.1M | 37,800 | 0.00% | 6q | -41.6%-$804.8K |
| DEUTSCHE BANK AG\ | $1.0M | 34,993 | 0.00% | 6q | +72.7%+$439.5K |
| WELLS FARGO & COMPANY/MN | $956.3K | 32,047 | 0.00% | 6q | +209.1%+$646.9K |
| CITIGROUP INC | $903.1K | 30,265 | 0.00% | 6q | +253.4%+$647.6K |
| Quadrature Capital Ltd | $896.6K | 30,047 | 0.01% | new | NEW |
| Invesco Ltd. | $846.6K | 28,372 | 0.00% | 6q | -67.2%-$1.7M |
| AQR CAPITAL MANAGEMENT LLC | $810.5K | 27,161 | 0.00% | 5q | -2.8%-$23.4K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $777.7K | 26,063 | 0.00% | 6q | +1716.2%+$734.9K |
| STATE OF WISCONSIN INVESTMENT BOARD | $711.4K | 23,840 | 0.00% | new | NEW |
| BARCLAYS PLC | $708.2K | 23,733 | 0.00% | 6q | +156.2%+$431.8K |
| TD Asset Management Inc | $661.7K | 22,174 | 0.00% | new | NEW |
| MetLife Investment Management, LLC | $623.6K | 20,899 | 0.00% | 4q | +43.7%+$189.7K |
| Balyasny Asset Management L.P. | $602.5K | 20,190 | 0.00% | 4q | -95.6%-$13.2M |
| Squarepoint Ops LLC | $579.9K | 19,434 | 0.00% | 2q | +42.8%+$173.7K |
| Verition Fund Management LLC | $543.1K | 18,201 | 0.00% | 3q | -4.9%-$27.8K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $529.3K | 17,739 | 0.00% | 3q | +4054.3%+$516.6K |
| Jackson Creek Investment Advisors LLC | $494.0K | 18,345 | 0.16% | new | NEW |
| VANGUARD ASSET MANAGEMENT, Ltd | $490.4K | 16,436 | 0.00% | new | NEW |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $489.4K | 16,402 | 0.00% | 3q | +12.6%+$54.7K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $484.8K | 16,248 | 0.00% | 6q | +30.9%+$114.3K |
Showing the largest 100 of 162 reported holders.
What the company announced
Form 8-K filings from the last 120 days, showing only the items worth a reader's attention. Earnings releases, exhibit attachments and general disclosures are filed constantly and are left out. Filed is when the SEC received it; event is the date the company says the thing happened.
| Filed | Event date | What | Source |
|---|---|---|---|
| 2026-10-16 | 2026-10-15 | Material agreement entered | filing |
| 2026-08-17 | 2026-08-13 | Directors or officers departed or appointed | filing |
What the insiders did
Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.
Officers and directors
| Date | Insider | Role | Side | Shares | Value |
|---|---|---|---|---|---|
| 2026-07-01 | Coloma Jason V | Chief Executive Officer | Sold | 34,501 | $1.0M ×3 |
| 2026-10-01 | Coloma Jason V | Chief Executive Officer | Sold | 34,501 | $932.3K ×2 |
| 2026-08-03 | Coloma Jason V | Chief Executive Officer | Sold | 34,501 | $922.3K ×4 |
| 2026-09-01 | Coloma Jason V | Chief Executive Officer | Sold | 34,501 | $907.0K ×2 |
| 2026-05-26 | Coloma Jason V | Chief Executive Officer | Sold | 25,582 | $665.5K |
| 2026-06-23 | Coloma Jason V | Chief Executive Officer | Sold | 23,865 | $621.7K |
| 2026-08-13 | Bernstein Harold | President, R&D & CMO | Sold | 16,142 | $445.6K |
| 2026-07-01 | Bernstein Harold | President, R&D & CMO | Sold | 14,609 | $436.9K ×2 |
| 2026-10-01 | Bernstein Harold | President, R&D & CMO | Sold | 16,141 | $434.7K |
| 2026-09-01 | Bernstein Harold | President, R&D & CMO | Sold | 16,141 | $425.5K |
| 2026-05-14 | Bernstein Harold | President, R&D & CMO | Sold | 15,000 | $393.4K |
| 2026-06-01 | Bernstein Harold | President, R&D & CMO | Sold | 14,853 | $381.1K ×2 |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q3 2026 | 19 | $3.7M | 135,762 | 4 | 6 | 4 | 0.0% |
| Q2 2026 | 162 | $1.7B | 58,534,416 | 40 | 65 | 37 | 0.2% |
| Q1 2026 | 168 | $1.6B | 51,677,471 | 49 | 57 | 36 | 0.9% |
| Q4 2025 | 146 | $2.0B | 48,366,868 | 53 | 46 | 20 | 0.1% |
| Q3 2025 | 95 | $1.1B | 42,978,530 | 24 | 38 | 14 | 0.1% |
| Q2 2025 | 75 | $476.7M | 38,837,530 | 13 | 24 | 12 | 0.0% |
| Q1 2025 | 68 | $441.4M | 40,038,674 | 67 | 0 | 0 | 0.0% |